-90009.jpg)
Angiopoietin-2 (Ang-2) is a secreted glycoprotein that plays a complex role in vascular development. Ang-2 contains an N-terminal coiled-coildomain, 58 - 254 amino acids (aa) and a C-terminal fibrinogen-like domain, 281 - 467 aa, that is also found in other proteins including fibrinogen, tenascin, and ficolin. Located at the N-terminus are stretches of hydrophobic residues typical of secretory signal sequences. While Ang-2 is widely expressed in the mouse embryo, it is restricted postnatally to pro-angiogenic regions including the placenta, ovaries, and uterus. Ang-2 has been implicated in cancer development due to its role in angiogenesis.Ang-2-mediated destabilization of mature vessel structures accompanied by the presence of VEGF, may contribute to the angiogenesis associated with tumor tissues.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA009Hu01 | Recombinant Angiopoietin 2 (ANGPT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA009Hu02 | Recombinant Angiopoietin 2 (ANGPT2) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA009Hu01 | Active Angiopoietin 2 (ANGPT2) | Cell culture; Activity Assays. | |
| RPA009Hu03 | Recombinant Angiopoietin 2 (ANGPT2) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA009Hu01 | Polyclonal Antibody to Angiopoietin 2 (ANGPT2) | WB,IHC |
| MAA009Hu22 | Monoclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IP. | |
| PAA009Hu02 | Polyclonal Antibody to Angiopoietin 2 (ANGPT2) | WB | |
| LAA009Hu71 | Biotin-Linked Polyclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC. | |
| Assay Kits | SEA009Hu | ELISA Kit for Angiopoietin 2 (ANGPT2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA009Hu | CLIA Kit for Angiopoietin 2 (ANGPT2) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA009Mu01 | Recombinant Angiopoietin 2 (ANGPT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA009Mu02 | Recombinant Angiopoietin 2 (ANGPT2) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA009Mu01 | Polyclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IP. |
| LAA009Mu71 | Biotin-Linked Polyclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC. | |
| LAA009Mu81 | FITC-Linked Polyclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IF. | |
| PAA009Mu02 | Polyclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA009Mu | ELISA Kit for Angiopoietin 2 (ANGPT2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA009Ra01 | Recombinant Angiopoietin 2 (ANGPT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA009Ra02 | Recombinant Angiopoietin 2 (ANGPT2) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA009Ra01 | Polyclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IP. |
| PAA009Ra02 | Polyclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IP. | |
| LAA009Ra71 | Biotin-Linked Polyclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC. | |
| Assay Kits | SEA009Ra | ELISA Kit for Angiopoietin 2 (ANGPT2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Cavia (Guinea pig )
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA009Gu01 | Recombinant Angiopoietin 2 (ANGPT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA009Gu01 | Polyclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Angiopoietin 2 (ANGPT2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Angiopoietin 2 (ANGPT2) | ELISA Kit Customized Service Offer |
Organism species: Oryctolagus cuniculus (Rabbit)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA009Rb01 | Recombinant Angiopoietin 2 (ANGPT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA009Rb51 | Polyclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IP. |
| MAA009Rb21 | Monoclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IP. | |
| PAA009Rb01 | Polyclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA009Rb | ELISA Kit for Angiopoietin 2 (ANGPT2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA009Rb | CLIA Kit for Angiopoietin 2 (ANGPT2) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA009Po01 | Recombinant Angiopoietin 2 (ANGPT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA009Po01 | Polyclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IP. |
| MAA009Po21 | Monoclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA009Po | ELISA Kit for Angiopoietin 2 (ANGPT2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA009Bo01 | Recombinant Angiopoietin 2 (ANGPT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA009Bo01 | Polyclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Angiopoietin 2 (ANGPT2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Angiopoietin 2 (ANGPT2) | ELISA Kit Customized Service Offer |
Organism species: Chicken (Gallus)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA009Ga01 | Recombinant Angiopoietin 2 (ANGPT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA009Ga01 | Polyclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Angiopoietin 2 (ANGPT2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Angiopoietin 2 (ANGPT2) | ELISA Kit Customized Service Offer |
- "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis."Science 277:55-60(1997) [PubMed] [Europe PMC] [Abstract]
- "Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma."J. Clin. Invest. 103:341-345(1999) [PubMed] [Europe PMC] [Abstract]
- "Characterization and expression of a novel alternatively spliced human angiopoietin-2."J. Biol. Chem. 275:18550-18556(2000) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats."J. Biol. Chem. 278:1721-1727(2003) [PubMed] [Europe PMC] [Abstract]
- "Biological characterization of angiopoietin-3 and angiopoietin-4."FASEB J. 18:1200-1208(2004) [PubMed] [Europe PMC] [Abstract]
- "Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells."Angiogenesis 12:25-33(2009) [PubMed] [Europe PMC] [Abstract]
- "Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium."Mol. Cell. Biol. 29:2011-2022(2009) [PubMed] [Europe PMC] [Abstract]
- "Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system."Nat. Rev. Mol. Cell Biol. 10:165-177(2009) [PubMed] [Europe PMC] [Abstract]
- "Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition."Structure 13:825-832(2005) [PubMed] [Europe PMC] [Abstract]
- "Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex."Nat. Struct. Mol. Biol. 13:524-532(2006) [PubMed] [Europe PMC] [Abstract]