Insulin Like Growth Factor 1 (IGF1)

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IGFI; IGF1A; IBP1; MGF; Somatomedin C; Mechano Growth Gactor

Insulin Like Growth Factor 1 (IGF1)

Insulin-like Growth Factor I is a member of the insulin superfamily. It was originally discovered as a mediator of growth hormone actions on somatic cell growth, but has also been shown to be an important regulator of cell metabolism, differentiation and survival. IGF-I is synthesized as a preproprotein that is proteolytically cleaved to generate the mature protein linked by three disulfide bonds.

Mature IGF-I is highly conserved among mammals, with 100% sequence identity between the Porcine, bovine, porcine, equine and canine proteins. IGF-I is synthesized in the liver and multiple other tissues. It is found in blood and other body fluids as a complex with specific high affinity IGF binding proteins (IGFBP-1to-6).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA050Hu01 Recombinant Insulin Like Growth Factor 1 (IGF1) Positive Control; Immunogen; SDS-PAGE; WB.
EPA050Hu61 Eukaryotic Insulin Like Growth Factor 1 (IGF1) Positive Control; Immunogen; SDS-PAGE; WB.
CPA050Hu21 OVA Conjugated Insulin Like Growth Factor 1 (IGF1) Immunogen; SDS-PAGE; WB.
APA050Hu61 Active Insulin Like Growth Factor 1 (IGF1) Cell culture; Activity Assays.
APA050Hu01 Active Insulin Like Growth Factor 1 (IGF1) Cell culture; Activity Assays.
Antibodies MAA050Hu22 Monoclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
LAA050Hu71 Biotin-Linked Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC.
PAA050Hu01 Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
PAA050Hu06 Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
PAA050Hu08 Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
MAA050Hu21 Monoclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
LAA050Hu72 Biotin-Linked Monoclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC.
Assay Kits SEA050Hu ELISA Kit for Insulin Like Growth Factor 1 (IGF1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA050Hu CLIA Kit for Insulin Like Growth Factor 1 (IGF1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA050Mu01 Recombinant Insulin Like Growth Factor 1 (IGF1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA050Mu02 Recombinant Insulin Like Growth Factor 1 (IGF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA050Mu01 Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
LAA050Mu71 Biotin-Linked Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC.
LAA050Mu81 FITC-Linked Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IF.
PAA050Mu02 Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
Assay Kits SEA050Mu ELISA Kit for Insulin Like Growth Factor 1 (IGF1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA050Mu CLIA Kit for Insulin Like Growth Factor 1 (IGF1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA050Ra01 Recombinant Insulin Like Growth Factor 1 (IGF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA050Ra01 Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
MAA050Ra21 Monoclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
LAA050Ra71 Biotin-Linked Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC.
Assay Kits SEA050Ra ELISA Kit for Insulin Like Growth Factor 1 (IGF1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Cavia (Guinea pig )

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA050Gu01 Recombinant Insulin Like Growth Factor 1 (IGF1) Positive Control; Immunogen; SDS-PAGE; WB.
CPA050Gu21 OVA Conjugated Insulin Like Growth Factor 1 (IGF1) Immunogen; SDS-PAGE; WB.
Antibodies PAA050Gu01 Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
MAA050Gu21 Monoclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
PAA050Gu08 Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
LAA050Gu71 Biotin-Linked Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC.
Assay Kits SEA050Gu ELISA Kit for Insulin Like Growth Factor 1 (IGF1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA050Rb01 Recombinant Insulin Like Growth Factor 1 (IGF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA050Rb51 Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
MAA050Rb21 Monoclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
LAA050Rb71 Biotin-Linked Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC.
Assay Kits SEA050Rb ELISA Kit for Insulin Like Growth Factor 1 (IGF1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA050Si01 Recombinant Insulin Like Growth Factor 1 (IGF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA050Si01 Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Insulin Like Growth Factor 1 (IGF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Like Growth Factor 1 (IGF1) ELISA Kit Customized Service Offer

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA050Ca01 Recombinant Insulin Like Growth Factor 1 (IGF1) Positive Control; Immunogen; SDS-PAGE; WB.
CPA050Ca21 OVA Conjugated Insulin Like Growth Factor 1 (IGF1) Immunogen; SDS-PAGE; WB.
Antibodies PAA050Ca01 Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
MAA050Ca21 Monoclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
PAA050Ca08 Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
LAA050Ca71 Biotin-Linked Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC.
Assay Kits SEA050Ca ELISA Kit for Insulin Like Growth Factor 1 (IGF1) Enzyme-linked immunosorbent assay for Antigen Detection.
HEA050Ca High Sensitive ELISA Kit for Insulin Like Growth Factor 1 (IGF1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA050Po01 Recombinant Insulin Like Growth Factor 1 (IGF1) Positive Control; Immunogen; SDS-PAGE; WB.
CPA050Po21 OVA Conjugated Insulin Like Growth Factor 1 (IGF1) Immunogen; SDS-PAGE; WB.
Antibodies PAA050Po01 Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
LAA050Po71 Biotin-Linked Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC.
LAA050Po81 FITC-Linked Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IF.
MAA050Po21 Monoclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
PAA050Po08 Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
Assay Kits SEA050Po ELISA Kit for Insulin Like Growth Factor 1 (IGF1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA050Bo01 Recombinant Insulin Like Growth Factor 1 (IGF1) Positive Control; Immunogen; SDS-PAGE; WB.
CPA050Bo21 OVA Conjugated Insulin Like Growth Factor 1 (IGF1) Immunogen; SDS-PAGE; WB.
Antibodies PAA050Bo01 Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
MAA050Bo21 Monoclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
PAA050Bo08 Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
LAA050Bo71 Biotin-Linked Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC.
Assay Kits SEA050Bo ELISA Kit for Insulin Like Growth Factor 1 (IGF1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA050Bo CLIA Kit for Insulin Like Growth Factor 1 (IGF1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA050Ga01 Recombinant Insulin Like Growth Factor 1 (IGF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA050Ga01 Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
MAA050Ga21 Monoclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC; IP.
LAA050Ga71 Biotin-Linked Polyclonal Antibody to Insulin Like Growth Factor 1 (IGF1) WB; IHC; ICC.
Assay Kits SEA050Ga ELISA Kit for Insulin Like Growth Factor 1 (IGF1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Sequence of cDNA encoding human insulin-like growth factor I precursor."Nature 306:609-611(1983) [PubMed] [Europe PMC] [Abstract]
  2. "Organization of the human genes for insulin-like growth factors I and II."FEBS Lett. 195:179-184(1986) [PubMed] [Europe PMC] [Abstract]
  3. "Complete characterization of the human IGF-I nucleotide sequence isolated from a newly constructed adult liver cDNA library."FEBS Lett. 196:108-112(1986) [PubMed] [Europe PMC] [Abstract]
  4. "Organization and sequence of the human insulin-like growth factor I gene. Alternative RNA processing produces two insulin-like growth factor I precursor peptides."J. Biol. Chem. 261:4828-4832(1986) [PubMed] [Europe PMC] [Abstract]
  5. "Two insulin-like growth factor I messenger RNAs are expressed in human liver."Proc. Natl. Acad. Sci. U.S.A. 83:77-81(1986) [PubMed] [Europe PMC] [Abstract]
  6. "A novel human insulin-like growth factor I messenger RNA is expressed in normal and tumor cells."Mol. Endocrinol. 4:1914-1920(1990) [PubMed] [Europe PMC] [Abstract]
  7. "Complete nucleotide sequence of the high molecular weight human IGF-I mRNA."Biochem. Biophys. Res. Commun. 175:507-514(1991) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of two cDNAs encoding insulin-like growth factor 1 (IGF-1) in the human fetal brain."Brain Res. Mol. Brain Res. 12:275-277(1992) [PubMed] [Europe PMC] [Abstract]
  9. "Characterization of insulin-like growth factor 1 in human primary brain tumors."Cancer Res. 53:2475-2478(1993) [PubMed] [Europe PMC] [Abstract]
  10. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Insulin-like growth factor II precursor gene organization in relation to insulin gene family."Nature 310:777-781(1984) [PubMed] [Europe PMC] [Abstract]
  13. "The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin."J. Biol. Chem. 253:2769-2776(1978) [PubMed] [Europe PMC] [Abstract]
  14. "Location of disulphide bonds in human insulin-like growth factors (IGFs) synthesized by recombinant DNA technology."Biomed. Environ. Mass Spectrom. 16:3-8(1988) [PubMed] [Europe PMC] [Abstract]
  15. "Stimulation of glucose transport in osteoblastic cells by parathyroid hormone and insulin-like growth factor I."Mol. Cell. Biochem. 348:33-42(2011) [PubMed] [Europe PMC] [Abstract]
  16. "SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients."Nature 503:267-271(2013) [PubMed] [Europe PMC] [Abstract]
  17. "Tertiary structures, receptor binding, and antigenicity of insulinlike growth factors."Fed. Proc. 42:2592-2597(1983) [PubMed] [Europe PMC] [Abstract]
  18. "Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study."Biochemistry 30:5484-5491(1991) [PubMed] [Europe PMC] [Abstract]
  19. "1H-NMR assignment and secondary structure of human insulin-like growth factor-I (IGF-I) in solution."J. Biochem. 111:529-536(1992) [PubMed] [Europe PMC] [Abstract]
  20. "Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene."N. Engl. J. Med. 335:1363-1367(1996) [PubMed] [Europe PMC] [Abstract]
  21. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  22. ErratumNat. Genet. 23:373-373(1999)