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Neurotrophin-3,or NT-3 is a protein that is encoded by the NTF3 gene, NT-3 is a neurotrophic factor, in the NGF (Nerve Growth Factor)-family of neurotrophins. It is a protein growth factor which has activity on certain neurons of the peripheral and central nervous system; it helps to support the survival and differentiation of existing neurons, and encourages the growth and differentiation of new neurons and synapses.
NT-3 was the third neurotrophic factor to be characterized, after nerve growth factor (NGF) and BDNF (Brain Derived Neurotrophic). NT-3 is unique in the number of neurons it can potentially stimulate, given its ability to activate two of the receptor tyrosine kinase neurotrophin receptors (TrkC and TrkB).
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA106Hu01 | Recombinant Neurotrophin 3 (NT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA106Hu02 | Recombinant Neurotrophin 3 (NT3) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA106Hu01 | Polyclonal Antibody to Neurotrophin 3 (NT3) | WB; IHC; ICC; IP. |
| MAA106Hu22 | Monoclonal Antibody to Neurotrophin 3 (NT3) | WB; IHC; ICC; IP. | |
| PAA106Hu02 | Polyclonal Antibody to Neurotrophin 3 (NT3) | WB; IHC; ICC; IP. | |
| LAA106Hu71 | Biotin-Linked Polyclonal Antibody to Neurotrophin 3 (NT3) | WB; IHC; ICC. | |
| MAA106Hu21 | Monoclonal Antibody to Neurotrophin 3 (NT3) | WB; IHC; ICC; IP. | |
| MAA106Hu23 | Monoclonal Antibody to Neurotrophin 3 (NT3) | WB; IHC; ICC; IP. | |
| MAA106Hu24 | Monoclonal Antibody to Neurotrophin 3 (NT3) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA106Hu | ELISA Kit for Neurotrophin 3 (NT3) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA106Hu | CLIA Kit for Neurotrophin 3 (NT3) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA106Mu01 | Recombinant Neurotrophin 3 (NT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA106Mu02 | Recombinant Neurotrophin 3 (NT3) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA106Mu01 | Polyclonal Antibody to Neurotrophin 3 (NT3) | WB; IHC; ICC; IP. |
| PAA106Mu02 | Polyclonal Antibody to Neurotrophin 3 (NT3) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA106Mu | ELISA Kit for Neurotrophin 3 (NT3) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA106Ra01 | Recombinant Neurotrophin 3 (NT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA106Ra02 | Recombinant Neurotrophin 3 (NT3) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA106Ra01 | Polyclonal Antibody to Neurotrophin 3 (NT3) | WB; IHC; ICC; IP. |
| MAA106Ra21 | Monoclonal Antibody to Neurotrophin 3 (NT3) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA106Ra | ELISA Kit for Neurotrophin 3 (NT3) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA106Po01 | Recombinant Neurotrophin 3 (NT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA106Po01 | Polyclonal Antibody to Neurotrophin 3 (NT3) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Neurotrophin 3 (NT3) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Neurotrophin 3 (NT3) | ELISA Kit Customized Service Offer |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA106Bo01 | Recombinant Neurotrophin 3 (NT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA106Bo01 | Polyclonal Antibody to Neurotrophin 3 (NT3) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Neurotrophin 3 (NT3) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Neurotrophin 3 (NT3) | ELISA Kit Customized Service Offer |
Organism species: Chicken (Gallus)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA106Ga01 | Recombinant Neurotrophin 3 (NT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA106Ga01 | Polyclonal Antibody to Neurotrophin 3 (NT3) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Neurotrophin 3 (NT3) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Neurotrophin 3 (NT3) | ELISA Kit Customized Service Offer |
Organism species: Xenopus (Clawed frog)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Neurotrophin 3 (NT3) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Neurotrophin 3 (NT3) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Neurotrophin 3 (NT3) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Neurotrophin 3 (NT3) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Neurotrophin 3 (NT3) | ELISA Kit Customized Service Offer |
- "Cloning and expression of a cDNA encoding a novel human neurotrophic factor."FEBS Lett. 266:187-191(1990) [PubMed] [Europe PMC] [Abstract]
- "Primary structure and biological activity of a novel human neurotrophic factor."Neuron 4:767-773(1990) [PubMed] [Europe PMC] [Abstract]
- "Molecular cloning of a human gene that is a member of the nerve growth factor family."Proc. Natl. Acad. Sci. U.S.A. 87:8060-8064(1990) [PubMed] [Europe PMC] [Abstract]
- "Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations."Genomics 10:558-568(1991) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary."Neuron 6:845-858(1991) [PubMed] [Europe PMC] [Abstract]
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- "Association of neurotrophin-3 gene variant with severe forms of schizophrenia."Biochem. Biophys. Res. Commun. 209:513-518(1995) [PubMed] [Europe PMC] [Abstract]
- "Failure to find associations of the CA repeat polymorphism in the first intron and the Gly-63/Glu-63 polymorphism of the neurotrophin-3 gene with schizophrenia."Psychiatr. Genet. 6:13-15(1996) [PubMed] [Europe PMC] [Abstract]