Osteoprotegerin (OPG)

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TNFRSF11B; TNFRSF11-B; OCIF; OPG; TR1; Tumor Necrosis Factor Receptor Superfamily Member 11b; Osteoclastogenesis Inhibitory Factor

Osteoprotegerin (OPG)

Osteoprotegerin (OPG) is a cytokine, which can inhibit the production of osteoclasts. It is a member of the tumor necrosis factor (TNF) receptor superfamily. It is a basic glycoprotein comprising 401 amino acid residues arranged into 7 structural domains. It is found as either a 60 kDa monomer or 120 kDa dimer linked by disulfide bonds.Osteoprotegerin inhibits the differentiation of osteoclast precursors into osteoclasts and also regulates the resorption of osteoclasts in vitro and in vivo. Osteoprotegerin is a RANK homolog, and works by binding to RANKL on osteoblast/stromal cells, thus blocking the RANKL-RANK ligand interaction between osteoblast/stromal cells and osteoclast precursors. This has the effect of inhibiting the differentiation of the osteoclast precursor into a mature osteoclast.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA108Hu01Recombinant Osteoprotegerin (OPG)Positive Control; Immunogen; SDS-PAGE; WB.
EPA108Hu61Eukaryotic Osteoprotegerin (OPG)Positive Control; Immunogen; SDS-PAGE; WB.
APA108Hu01Active Osteoprotegerin (OPG)Cell culture; Activity Assays.
AntibodiesPAA108Hu01Polyclonal Antibody to Osteoprotegerin (OPG)WB; IHC; ICC; IP.
MAA108Hu22Monoclonal Antibody to Osteoprotegerin (OPG)WB; IHC; ICC; IP.
PAA108Hu06Polyclonal Antibody to Osteoprotegerin (OPG)WB; IHC; ICC; IP.
Assay KitsSEA108HuELISA Kit for Osteoprotegerin (OPG)Enzyme-linked immunosorbent assay for Antigen Detection.
SCA108HuCLIA Kit for Osteoprotegerin (OPG)Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA108Mu01Recombinant Osteoprotegerin (OPG)Positive Control; Immunogen; SDS-PAGE; WB.
RPA108Mu02Recombinant Osteoprotegerin (OPG)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAA108Mu01Polyclonal Antibody to Osteoprotegerin (OPG)WB; IHC; ICC; IP.
PAA108Mu02Polyclonal Antibody to Osteoprotegerin (OPG)WB; IHC; ICC; IP.
Assay KitsSEA108MuELISA Kit for Osteoprotegerin (OPG)Enzyme-linked immunosorbent assay for Antigen Detection.
SCA108MuCLIA Kit for Osteoprotegerin (OPG)Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA108Ra01Recombinant Osteoprotegerin (OPG)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAA108Ra01Polyclonal Antibody to Osteoprotegerin (OPG)WB; IHC; ICC; IP.
MAA108Ra21Monoclonal Antibody to Osteoprotegerin (OPG)WB; IHC; ICC; IP.
Assay KitsSEA108RaELISA Kit for Osteoprotegerin (OPG)Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA108Po01Recombinant Osteoprotegerin (OPG)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAA108Po01Polyclonal Antibody to Osteoprotegerin (OPG)WB; IHC; ICC; IP.
MAA108Po21Monoclonal Antibody to Osteoprotegerin (OPG)WB; IHC; ICC; IP.
Assay KitsSEA108PoELISA Kit for Osteoprotegerin (OPG)Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA108Cp01Recombinant Osteoprotegerin (OPG)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAA108Cp01Polyclonal Antibody to Osteoprotegerin (OPG)WB; IHC; ICC; IP.
Assay Kitsn/aCLIA Kit for Osteoprotegerin (OPG)CLIA Kit Customized Service Offer
n/aELISA Kit for Osteoprotegerin (OPG)ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA108Ga01Recombinant Osteoprotegerin (OPG)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAA108Ga01Polyclonal Antibody to Osteoprotegerin (OPG)WB; IHC; ICC; IP.
MAA108Ga01Monoclonal Antibody to Osteoprotegerin (OPG)WB; IHC; ICC; IP.
Assay KitsSEA108GaELISA Kit for Osteoprotegerin (OPG)Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Osteoprotegerin: a novel secreted protein involved in the regulation of bone density." Cell 89:309-319(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro."Endocrinology 139:1329-1337(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and characterization of the gene encoding human osteoprotegerin/osteoclastogenesis-inhibitory factor."Eur. J. Biochem. 254:685-691(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
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  8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Cloning and expression of a novel mutated osteoprogerin/osteoclastogenesis inhibitory factor gene."Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 31:680-684(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis."Biochem. Biophys. Res. Commun. 234:137-142(1997) [PubMed] [Europe PMC] [Abstract]
  11. "Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL."J. Biol. Chem. 273:14363-14367(1998) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization of structural domains of human osteoclastogenesis inhibitory factor."J. Biol. Chem. 273:5117-5123(1998) [PubMed] [Europe PMC] [Abstract]
  13. "Receptor activator of nuclear factor-kappaB ligand and osteoprotegerin: potential implications for the pathogenesis and treatment of malignant bone diseases."Cancer 92:460-470(2001) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of human RANKL complexed with its decoy receptor osteoprotegerin."J. Immunol. 189:245-252(2012) [PubMed] [Europe PMC] [Abstract]
  15. "A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype."Hum. Mol. Genet. 11:2119-2127(2002) [PubMed] [Europe PMC] [Abstract]