Cluster Of Differentiation 40 Ligand (CD40L)
[Edit]CD154; TRAP; HIGM1; IGM; IMD3; TBAM; T-BAM; TNFSF5; Gp39; TNF Superfamily Member 5; Hyper-IgM Syndrome; TNF-Related Activation Protein; T-Cell B-Cell Activating Molecule
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is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In general, CD40L plays the role of a costimulatory molecule and induces activation in APC in association with T cell receptor stimulation by MHC molecules on the APC. In total CD40L has three binding partners: CD40, α5β1 integrin and αIIbβ3.
CD40L is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper IgM syndrome.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA119Mu01 | Recombinant Cluster Of Differentiation 40 Ligand (CD40L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA119Mu02 | Recombinant Cluster Of Differentiation 40 Ligand (CD40L) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA119Mu01 | Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) | WB; IHC; ICC; IP. |
| PAA119Mu02 | Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA119Mu | ELISA Kit for Cluster Of Differentiation 40 Ligand (CD40L) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA119Ra01 | Recombinant Cluster Of Differentiation 40 Ligand (CD40L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA119Ra01 | Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) | WB |
| MAA119Ra21 | Monoclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) | IHC | |
| MAA119Ra22 | Monoclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) | IHC | |
| Assay Kits | SEA119Ra | ELISA Kit for Cluster Of Differentiation 40 Ligand (CD40L) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Oryctolagus cuniculus (Rabbit)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Cluster Of Differentiation 40 Ligand (CD40L) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | SEA119Rb | ELISA Kit for Cluster Of Differentiation 40 Ligand (CD40L) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rhesus monkey (Simian)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA119Si01 | Recombinant Cluster Of Differentiation 40 Ligand (CD40L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA119Si02 | Recombinant Cluster Of Differentiation 40 Ligand (CD40L) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA119Si01 | Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) | IHC |
| Assay Kits | n/a | CLIA Kit for Cluster Of Differentiation 40 Ligand (CD40L) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cluster Of Differentiation 40 Ligand (CD40L) | ELISA Kit Customized Service Offer |
Organism species: Canis familiaris; Canine (Dog)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA119Ca01 | Recombinant Cluster Of Differentiation 40 Ligand (CD40L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA119Ca01 | Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) | WB; IHC; ICC; IP. |
| MAA119Ca21 | Monoclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA119Ca | ELISA Kit for Cluster Of Differentiation 40 Ligand (CD40L) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA119Po01 | Recombinant Cluster Of Differentiation 40 Ligand (CD40L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA119Po02 | Recombinant Cluster Of Differentiation 40 Ligand (CD40L) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| RPA119Po03 | Recombinant Cluster Of Differentiation 40 Ligand (CD40L) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA119Po01 | Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) | WB |
| PAA119Po02 | Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) | WB; IHC; ICC; IP. | |
| PAA119Po03 | Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) | WB | |
| Assay Kits | SEA119Po | ELISA Kit for Cluster Of Differentiation 40 Ligand (CD40L) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA119Bo01 | Recombinant Cluster Of Differentiation 40 Ligand (CD40L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA119Bo01 | Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) | WB; IHC; ICC; IP. |
| LAA119Bo81 | FITC-Linked Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) | WB; IHC; ICC; IF. | |
| LAA119Bo71 | Biotin-Linked Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) | WB; IHC; ICC. | |
| Assay Kits | n/a | CLIA Kit for Cluster Of Differentiation 40 Ligand (CD40L) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cluster Of Differentiation 40 Ligand (CD40L) | ELISA Kit Customized Service Offer |
Organism species: Chicken (Gallus)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA119Ga01 | Recombinant Cluster Of Differentiation 40 Ligand (CD40L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA119Ga01 | Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Cluster Of Differentiation 40 Ligand (CD40L) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cluster Of Differentiation 40 Ligand (CD40L) | ELISA Kit Customized Service Offer |
Organism species: Danio rerio (Zebrafish)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA119Fi01 | Recombinant Cluster Of Differentiation 40 Ligand (CD40L) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA119Fi01 | Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Cluster Of Differentiation 40 Ligand (CD40L) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cluster Of Differentiation 40 Ligand (CD40L) | ELISA Kit Customized Service Offer |
- "Cloning of TRAP, a ligand for CD40 on human T cells."Eur. J. Immunol. 22:3191-3194(1992) [PubMed] [Europe PMC] [Abstract]
- "The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity."EMBO J. 11:4313-4321(1992) [PubMed] [Europe PMC] [Abstract]
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- "Human CD40-ligand: molecular cloning, cellular distribution and regulation of expression by factors controlling IgE production."FEBS Lett. 315:259-266(1993) [PubMed] [Europe PMC] [Abstract]
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- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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- "Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia pastoris and Chinese hamster ovary cells."Protein Expr. Purif. 23:301-310(2001) [PubMed] [Europe PMC] [Abstract]
- "Release of soluble CD40L from platelets is regulated by glycoprotein IIb/IIIa and actin polymerization."J. Am. Coll. Cardiol. 43:2319-2325(2004) [PubMed] [Europe PMC] [Abstract]
- "2-A crystal structure of an extracellular fragment of human CD40 ligand."Structure 3:1031-1039(1995) [PubMed] [Europe PMC] [Abstract]
- "The role of polar interactions in the molecular recognition of CD40L with its receptor CD40."Protein Sci. 7:1124-1135(1998) [PubMed] [Europe PMC] [Abstract]
- "Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM."Nature 361:539-541(1993) [PubMed] [Europe PMC] [Abstract]
- "CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM."Nature 361:541-543(1993) [PubMed] [Europe PMC] [Abstract]
- "CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome."Science 259:990-993(1993) [PubMed] [Europe PMC] [Abstract]
- "Characterization of nine novel mutations in the CD40 ligand gene in patients with X-linked hyper IgM syndrome of various ancestry."Am. J. Hum. Genet. 56:898-906(1995) [PubMed] [Europe PMC] [Abstract]
- "Signaling through CD40 rescues IgE but not IgG or IgA secretion in X-linked immunodeficiency with hyper-IgM."J. Clin. Invest. 95:510-514(1995) [PubMed] [Europe PMC] [Abstract]
- "Mutation analysis in CD40 ligand deficiency leading to X-linked hypogammaglobulinemia with hyper IgM syndrome."Hum. Mutat. 8:223-228(1996) [PubMed] [Europe PMC] [Abstract]
- "A single strand conformation polymorphism study of CD40 ligand. Efficient mutation analysis and carrier detection for X-linked hyper IgM syndrome."J. Clin. Invest. 97:196-201(1996) [PubMed] [Europe PMC] [Abstract]
- "Mutations of the CD40 ligand gene in 13 Japanese patients with X-linked hyper-IgM syndrome."Hum. Genet. 99:624-627(1997) [PubMed] [Europe PMC] [Abstract]
- "Mutations of the CD40 ligand gene and its effect on CD40 ligand expression in patients with X-linked hyper IgM syndrome."Blood 92:2421-2434(1998) [PubMed] [Europe PMC] [Abstract]