Stem Cell Factor Receptor (SCFR)

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CD117; KIT; C-Kit; PBT; p145 c-Kit; C-Kit Receptor; Tyrosine-Protein Kinase; V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog; Piebald Trait

Stem Cell Factor Receptor (SCFR)

Stem cell factor Receptor(SCFR;CD117), also called KIT or C-kit receptor, is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. This receptor binds to stem cell factor (a substance that causes certain types of cells to grow). Altered forms of this receptor may be associated with some types of cancer.C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in its encoded gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA121Hu01Recombinant Stem Cell Factor Receptor (SCFR)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA121Hu01Polyclonal Antibody to Stem Cell Factor Receptor (SCFR)WB, ICC, IHC-P, IHC-F, ELISA
MAA121Hu22Monoclonal Antibody to Stem Cell Factor Receptor (SCFR)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA121HuELISA Kit for Stem Cell Factor Receptor (SCFR)Enzyme-linked immunosorbent assay
SCA121HuCLIA Kit for Stem Cell Factor Receptor (SCFR)Chemiluminescent immunoassay

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA121Mu01Recombinant Stem Cell Factor Receptor (SCFR)SDS-PAGE; WB; ELISA; IP.
RPA121Mu02Recombinant Stem Cell Factor Receptor (SCFR)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA121Mu01Polyclonal Antibody to Stem Cell Factor Receptor (SCFR)WB, ICC, IHC-P, IHC-F, ELISA
PAA121Mu02Polyclonal Antibody to Stem Cell Factor Receptor (SCFR)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA121MuELISA Kit for Stem Cell Factor Receptor (SCFR)Enzyme-linked immunosorbent assay

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Stem Cell Factor Receptor (SCFR)Recombinant Protein Customized Service Offer
AntibodiesMAA121Ra21Monoclonal Antibody to Stem Cell Factor Receptor (SCFR)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Stem Cell Factor Receptor (SCFR)CLIA Kit Customized Service Offer
n/aELISA Kit for Stem Cell Factor Receptor (SCFR)ELISA Kit Customized Service Offer
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  40. "Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase."J. Biol. Chem. 286:480-490(2011) [PubMed] [Europe PMC] [Abstract]
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  45. "Novel mutations of the KIT (mast/stem cell growth factor receptor) proto-oncogene in human piebaldism."J. Invest. Dermatol. 101:22-25(1993) [PubMed] [Europe PMC] [Abstract]
  46. "A 12-bp deletion (7818del12) in the c-kit protooncogene in a large Italian kindred with piebaldism."Hum. Mutat. 6:343-345(1995) [PubMed] [Europe PMC] [Abstract]
  47. "A new c-kit mutation in a case of aggressive mast cell disease."Br. J. Haematol. 96:374-376(1997) [PubMed] [Europe PMC] [Abstract]
  48. "Piebaldism with deafness: molecular evidence for an expanded syndrome."Am. J. Med. Genet. 75:101-103(1998) [PubMed] [Europe PMC] [Abstract]
  49. "c-kit activating mutations and mast cell proliferation in human leukemia."Blood 92:701-702(1998) [PubMed] [Europe PMC] [Abstract]
  50. "A novel KIT gene missense mutation in a Japanese family with piebaldism."J. Invest. Dermatol. 111:337-338(1998) [PubMed] [Europe PMC] [Abstract]
  51. "Familial gastrointestinal stromal tumours with germline mutation of the KIT gene."Nat. Genet. 19:323-324(1998) [PubMed] [Europe PMC] [Abstract]
  52. "Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors."Science 279:577-580(1998) [PubMed] [Europe PMC] [Abstract]
  53. "Activating c-kit gene mutations in human germ cell tumors."Am. J. Pathol. 154:1643-1647(1999) [PubMed] [Europe PMC] [Abstract]
  54. "Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis."Proc. Natl. Acad. Sci. U.S.A. 96:1609-1614(1999) [PubMed] [Europe PMC] [Abstract]
  55. "Three novel mutations of the proto-oncogene KIT cause human piebaldism."Am. J. Med. Genet. 95:79-81(2000) [PubMed] [Europe PMC] [Abstract]
  56. "Germline mutation in the juxtamembrane domain of the kit gene in a family with gastrointestinal stromal tumors and urticaria pigmentosa."Cancer 92:657-662(2001) [PubMed] [Europe PMC] [Abstract]
  57. "A mutation-created novel intra-exonic pre-mRNA splice site causes constitutive activation of KIT in human gastrointestinal stromal tumors."Oncogene 24:4271-4280(2005) [PubMed] [Europe PMC] [Abstract]
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