Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1)

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JTK14; Tyrosine Kinase With Immunoglobulin And Epidermal Growth Factor Homology Domains 1; Tyrosine-protein kinase receptor Tie-1

Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1)

Tie1 is a cell surface protein expressed exclusively in endothelial cells. Tie1 upregulates the cell adhesion molecules VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Attachment of monocyte derived immune cells to endothelial cells is also enhanced by Tie1 expression. Tie1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis. the combinatorial function of angiopoietin-1 and the orphan receptor TIE1 is critical for the development of the right-hand side venous system but is dispensable for the left-hand side venous system. This finding revealed the existence of a distinct genetic program for the establishment of the right-hand side and left-hand side vascular networks well before the network asymmetry becomes morphologically discernible.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA125Hu01 Recombinant Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA125Hu02 Recombinant Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA125Hu03 Recombinant Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA125Hu04 Recombinant Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA125Hu01 Polyclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; ICC; IHC-P; IHC-F; ELISA.
MAA125Hu22 Monoclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; IHC; ICC; IP.
PAA125Hu02 Polyclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; ICC; IHC-P; IHC-F; ELISA.
MAA125Hu21 Monoclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; IHC; ICC; IP.
PAA125Hu03 Polyclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; IHC; ICC; IP.
PAA125Hu04 Polyclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; IHC; ICC; IP.
Assay Kits SEA125Hu ELISA Kit for Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA125Mu01 Recombinant Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA125Mu02 Recombinant Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA125Mu01 Polyclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; IHC; ICC; IP.
PAA125Mu02 Polyclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; IHC; ICC; IP.
Assay Kits SEA125Mu ELISA Kit for Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA125Ra01 Recombinant Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA125Ra01 Polyclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA125Bo01 Recombinant Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA125Bo01 Polyclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) ELISA Kit Customized Service Offer

Organism species: Danio rerio (Zebrafish)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA125Fi01 Recombinant Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA125Fi01 Polyclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) ELISA Kit Customized Service Offer
  1. "A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains."Mol. Cell. Biol. 12:1698-1707(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis."Arthritis Res. Ther. 10:R73-R73(2008) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2."J. Cell Biol. 169:239-243(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands."Mol. Cell 37:643-655(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]