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Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A)

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CD261; TNFRSF10-A; APO2; DR4; TRAILR1; Death Receptor 4; TNF-Related Apoptosis-Inducing Ligand Receptor 1

Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A)
CCC A136
HGNC 11904
MGI 1341090
PubMed 24235014
UniProt O00220
Wiki TNFRSF10A

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.

Pan et al. (1997) found that, as with FAS, TNFR1, and DR3, overexpression of DR4 induced apoptosis. However, unlike the other 3 death receptors, DR4 did not use FADD  to transmit the death signal, suggesting the use of distinct proximal signaling machinery.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA136Hu01 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA136Mu01 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) Positive Control; Immunogen; SDS-PAGE; WB.
RPA136Mu02 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA136Mu01 Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) WB; IHC; ICC; IP.
PAA136Mu02 Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) WB; IHC; ICC; IP.
Assay Kits SEA136Mu ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 10A (TNFRSF10A) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The receptor for the cytotoxic ligand TRAIL."Science 276:111-113(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway."Immunity 7:821-830(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane."Apoptosis 13:423-436(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses."Cell Host Microbe 13:324-335(2013) [PubMed] [Europe PMC] [Abstract]