Intercellular Adhesion Molecule 5 (ICAM5)

[Edit]

TLCN; TLN; Telencephalin

Intercellular Adhesion Molecule 5 (ICAM5)

Intercellular adhesion molecule 5 is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.The 924-amino acid polypeptide comprises an N-terminal signal peptide, an extracellular region with 9 Ig-like domains, a single transmembrane region, and a C-terminal cytoplasmic tail.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA142Hu01 Recombinant Intercellular Adhesion Molecule 5 (ICAM5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA142Hu01 Polyclonal Antibody to Intercellular Adhesion Molecule 5 (ICAM5) WB; IHC; ICC; IP.
MAA142Hu22 Monoclonal Antibody to Intercellular Adhesion Molecule 5 (ICAM5) WB; IHC; ICC; IP.
Assay Kits SEA142Hu ELISA Kit for Intercellular Adhesion Molecule 5 (ICAM5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA142Mu01 Recombinant Intercellular Adhesion Molecule 5 (ICAM5) Positive Control; Immunogen; SDS-PAGE; WB.
RPA142Mu02 Recombinant Intercellular Adhesion Molecule 5 (ICAM5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA142Mu01 Polyclonal Antibody to Intercellular Adhesion Molecule 5 (ICAM5) WB; IHC; ICC; IP.
PAA142Mu02 Polyclonal Antibody to Intercellular Adhesion Molecule 5 (ICAM5) WB; IHC; ICC; IP.
Assay Kits SEA142Mu ELISA Kit for Intercellular Adhesion Molecule 5 (ICAM5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Intercellular Adhesion Molecule 5 (ICAM5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Intercellular Adhesion Molecule 5 (ICAM5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Intercellular Adhesion Molecule 5 (ICAM5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Intercellular Adhesion Molecule 5 (ICAM5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Intercellular Adhesion Molecule 5 (ICAM5) ELISA Kit Customized Service Offer

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA142Rb01 Recombinant Intercellular Adhesion Molecule 5 (ICAM5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA142Rb51 Polyclonal Antibody to Intercellular Adhesion Molecule 5 (ICAM5) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Intercellular Adhesion Molecule 5 (ICAM5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Intercellular Adhesion Molecule 5 (ICAM5) ELISA Kit Customized Service Offer
  1. "cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1."J. Biol. Chem. 272:1156-1163(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2."Genomics 54:328-330(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  5. "An unusual allosteric mobility of the C-terminal helix of a high-affinity alphaL integrin I domain variant bound to ICAM-5."Mol. Cell 31:432-437(2008) [PubMed] [Europe PMC] [Abstract]
  6. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]