Vascular Endothelial Growth Factor C (VEGFC)

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VEGF-C; Flt4-L; VRPL; Vascular Endothelial Growth Factor-Related Protein

Vascular Endothelial Growth Factor C (VEGFC)

VEGF-C has been shown to exhibit angiogenic and lymphangiogenic actions. The VEGF family of growth factors and receptors is involved in the development and growth of the vascular endothelial system. Two of its family members, VEGF-C and VEGF-D, regulate the lymphatic endothelial cells via their receptor VEGFR, thus acting as mitogens for these cells. VEGF-C expression is associated with hematological malignancies. Like VEGF it acts as survival factor on leukemia. Together with the expression of their receptors, VEGF and VEGF-C result in the generation of autocrine loops that may support cancer cell survival and proliferation. Further VEGF-C expression has been shown in gastrointestinal tract malignancies where it correlates with lymphatic invasion, lymphnode metastasis and reduced survival.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA145Hu01 Recombinant Vascular Endothelial Growth Factor C (VEGFC) Positive Control; Immunogen; SDS-PAGE; WB.
APA145Hu01 Active Vascular Endothelial Growth Factor C (VEGFC) Cell culture; Activity Assays.
EPA145Hu61 Eukaryotic Vascular Endothelial Growth Factor C (VEGFC) Positive Control; Immunogen; SDS-PAGE; WB.
RPA145Hu02 Recombinant Vascular Endothelial Growth Factor C (VEGFC) Positive Control; Immunogen; SDS-PAGE; WB.
APA145Hu61 Active Vascular Endothelial Growth Factor C (VEGFC) Cell culture; Activity Assays.
EPA145Hu62 Eukaryotic Vascular Endothelial Growth Factor C (VEGFC) Positive Control; Immunogen; SDS-PAGE; WB.
EPA145Hu63 Eukaryotic Vascular Endothelial Growth Factor C (VEGFC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA145Hu01 Polyclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) WB; IHC; ICC; IP.
MAA145Hu22 Monoclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) WB; IHC; ICC; IP.
MAA145Hu21 Monoclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) WB; IHC; ICC; IP.
MAA145Hu23 Monoclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) WB; IHC; ICC; IP.
MAA145Hu24 Monoclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) WB; IHC; ICC; IP.
Assay Kits SEA145Hu ELISA Kit for Vascular Endothelial Growth Factor C (VEGFC) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA145Hu CLIA Kit for Vascular Endothelial Growth Factor C (VEGFC) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA145Mu01 Recombinant Vascular Endothelial Growth Factor C (VEGFC) Positive Control; Immunogen; SDS-PAGE; WB.
RPA145Mu02 Recombinant Vascular Endothelial Growth Factor C (VEGFC) Positive Control; Immunogen; SDS-PAGE; WB.
EPA145Mu61 Eukaryotic Vascular Endothelial Growth Factor C (VEGFC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA145Mu01 Polyclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) WB; IHC; ICC; IP.
LAA145Mu71 Biotin-Linked Polyclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) WB; IHC; ICC.
LAA145Mu81 FITC-Linked Polyclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) WB; IHC; ICC; IF.
PAA145Mu02 Polyclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) WB; IHC; ICC; IP.
MAA145Mu21 Monoclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) WB
LAA145Mu72 Biotin-Linked Monoclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) WB; IHC; ICC.
Assay Kits SEA145Mu ELISA Kit for Vascular Endothelial Growth Factor C (VEGFC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA145Ra01 Recombinant Vascular Endothelial Growth Factor C (VEGFC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA145Ra01 Polyclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) WB; IHC; ICC; IP.
MAA145Ra22 Monoclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) WB
LAA145Ra71 Biotin-Linked Polyclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) WB; IHC; ICC.
LAA145Ra81 FITC-Linked Polyclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) WB; IHC; ICC; IF.
LAA145Ra72 Biotin-Linked Monoclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) WB; IHC; ICC.
MAA145Ra21 Monoclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) WB; IHC; ICC; IP.
Assay Kits SEA145Ra ELISA Kit for Vascular Endothelial Growth Factor C (VEGFC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA145Rb01 Recombinant Vascular Endothelial Growth Factor C (VEGFC) Positive Control; Immunogen; SDS-PAGE; WB.
EPA145Rb61 Eukaryotic Vascular Endothelial Growth Factor C (VEGFC) Positive Control; Immunogen; SDS-PAGE; WB.
APA145Rb61 Active Vascular Endothelial Growth Factor C (VEGFC) Cell culture; Activity Assays.
EPA145Rb62 Eukaryotic Vascular Endothelial Growth Factor C (VEGFC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA145Rb51 Polyclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) WB; IHC; ICC; IP.
PAA145Rb01 Polyclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) WB; IHC; ICC; IP.
Assay Kits SEA145Rb ELISA Kit for Vascular Endothelial Growth Factor C (VEGFC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA145Ca01 Recombinant Vascular Endothelial Growth Factor C (VEGFC) Positive Control; Immunogen; SDS-PAGE; WB.
EPA145Ca61 Eukaryotic Vascular Endothelial Growth Factor C (VEGFC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA145Ca01 Polyclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Vascular Endothelial Growth Factor C (VEGFC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vascular Endothelial Growth Factor C (VEGFC) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA145Bo01 Recombinant Vascular Endothelial Growth Factor C (VEGFC) Positive Control; Immunogen; SDS-PAGE; WB.
EPA145Bo61 Eukaryotic Vascular Endothelial Growth Factor C (VEGFC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA145Bo01 Polyclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Vascular Endothelial Growth Factor C (VEGFC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vascular Endothelial Growth Factor C (VEGFC) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA145Ga01 Recombinant Vascular Endothelial Growth Factor C (VEGFC) Positive Control; Immunogen; SDS-PAGE; WB.
EPA145Ga61 Eukaryotic Vascular Endothelial Growth Factor C (VEGFC) Positive Control; Immunogen; SDS-PAGE; WB.
EPA145Ga62 Eukaryotic Vascular Endothelial Growth Factor C (VEGFC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA145Ga01 Polyclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Vascular Endothelial Growth Factor C (VEGFC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vascular Endothelial Growth Factor C (VEGFC) ELISA Kit Customized Service Offer
  1. "A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases."EMBO J. 15:290-298(1996) [PubMed] [Europe PMC] [Abstract]
  2. ErratumEMBO J. 15:1751-1751(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4."Proc. Natl. Acad. Sci. U.S.A. 93:1988-1992(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of murine Flt4 ligand/VEGF-C."Oncogene 15:613-618(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Proteolytic processing regulates receptor specificity and activity of VEGF-C."EMBO J. 16:3898-3911(1997) [PubMed] [Europe PMC] [Abstract]
  9. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Mutation in vascular endothelial growth factor-C, a ligand for vascular endothelial growth factor receptor-3, is associated with autosomal dominant milroy-like primary lymphedema."Circ. Res. 112:956-960(2013) [PubMed] [Europe PMC] [Abstract]
  11. "A novel stop mutation in the vascular endothelial growth factor-C gene (VEGFC) results in Milroy-like disease."J. Med. Genet. 51:475-478(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Structural determinants of growth factor binding and specificity by VEGF receptor 2."Proc. Natl. Acad. Sci. U.S.A. 107:2425-2430(2010) [PubMed] [Europe PMC] [Abstract]