Platelet Factor 4 (PF4)

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CXCL4; SCYB4; Chemokine C-X-C-Motif Ligand 4; Oncostatin-A; Iroplact

Platelet Factor 4 (PF4)

Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family. This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin-like molecules. Due to these roles, it is predicted to play a role in wound repair and inflammation. It is usually found in a complex with proteoglycan.PF4 is chemotactic for neutrophils, fibroblasts and monocytes, and interacts with a splice variant of the chemokine receptor CXCR3, known as CXCR3B. PF4 is the antigen in heparin-induced thrombocytopenia, an idiosyncratic autoimmune reaction to the administration of the anticoagulant heparin. PF4 autoantibodies have also been found in patients with thrombosis and features resembling HIT but no prior administration of heparin.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA172Hu01Recombinant Platelet Factor 4 (PF4)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA172Hu01Polyclonal Antibody to Platelet Factor 4 (PF4)WB, ICC, IHC-P, IHC-F, ELISA
MAA172Hu22Monoclonal Antibody to Platelet Factor 4 (PF4)WB, ICC, IHC-P, IHC-F, ELISA
LAA172Hu71Biotin-Linked Polyclonal Antibody to Platelet Factor 4 (PF4)IHC;WB;ELISA
LAA172Hu81FITC-Linked Polyclonal Antibody to Platelet Factor 4 (PF4)IHC;ICC;IF;WB
Assay KitsSEA172HuELISA Kit for Platelet Factor 4 (PF4)Enzyme-linked immunosorbent assay for Antigen Detection
SCA172HuCLIA Kit for Platelet Factor 4 (PF4)Chemiluminescent immunoassay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA172Mu01Recombinant Platelet Factor 4 (PF4)SDS-PAGE; WB; ELISA; IP.
RPA172Mu02Recombinant Platelet Factor 4 (PF4)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA172Mu01Polyclonal Antibody to Platelet Factor 4 (PF4)WB, ICC, IHC-P, IHC-F, ELISA
PAA172Mu02Polyclonal Antibody to Platelet Factor 4 (PF4)WB, ICC, IHC-P, IHC-F, ELISA
LAA172Mu71Biotin-Linked Polyclonal Antibody to Platelet Factor 4 (PF4)IHC;WB;ELISA
LAA172Mu81FITC-Linked Polyclonal Antibody to Platelet Factor 4 (PF4)IHC;ICC;IF;WB
Assay KitsSEA172MuELISA Kit for Platelet Factor 4 (PF4)Enzyme-linked immunosorbent assay for Antigen Detection
SCA172MuCLIA Kit for Platelet Factor 4 (PF4)Chemiluminescent immunoassay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA172Ra01Recombinant Platelet Factor 4 (PF4)SDS-PAGE; WB; ELISA; IP.
RPA172Ra02Recombinant Platelet Factor 4 (PF4)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA172Ra01Polyclonal Antibody to Platelet Factor 4 (PF4)WB, ICC, IHC-P, IHC-F, ELISA
LAA172Ra71Biotin-Linked Polyclonal Antibody to Platelet Factor 4 (PF4)IHC;WB;ELISA
LAA172Ra81FITC-Linked Polyclonal Antibody to Platelet Factor 4 (PF4)IHC;ICC;IF;WB
PAA172Ra02Polyclonal Antibody to Platelet Factor 4 (PF4)WB, ICC, IHC-P, IHC-F, ELISA
MAA172Ra21Monoclonal Antibody to Platelet Factor 4 (PF4)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA172RaELISA Kit for Platelet Factor 4 (PF4)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA172Rb01Recombinant Platelet Factor 4 (PF4)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA172Rb51Polyclonal Antibody to Platelet Factor 4 (PF4)WB, ICC, IHC-P, IHC-F, ELISA
MAA172Rb21Monoclonal Antibody to Platelet Factor 4 (PF4)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA172RbELISA Kit for Platelet Factor 4 (PF4)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA172Po01Recombinant Platelet Factor 4 (PF4)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA172Po01Polyclonal Antibody to Platelet Factor 4 (PF4)WB, ICC, IHC-P, IHC-F, ELISA
MAA172Po21Monoclonal Antibody to Platelet Factor 4 (PF4)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA172PoELISA Kit for Platelet Factor 4 (PF4)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA172Bo01Recombinant Platelet Factor 4 (PF4)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA172Bo01Polyclonal Antibody to Platelet Factor 4 (PF4)WB, ICC, IHC-P, IHC-F, ELISA
MAA172Bo21Monoclonal Antibody to Platelet Factor 4 (PF4)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA172BoELISA Kit for Platelet Factor 4 (PF4)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA172Cp01Recombinant Platelet Factor 4 (PF4)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA172Cp01Polyclonal Antibody to Platelet Factor 4 (PF4)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Platelet Factor 4 (PF4)CLIA Kit Customized Service Offer
n/aELISA Kit for Platelet Factor 4 (PF4)ELISA Kit Customized Service Offer
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  2. "Structural and functional comparison of the genes for human platelet factor 4 and PF4alt."Blood 76:336-344(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus."Blood 98:610-617(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  7. "Amino acid sequence of human platelet factor 4."Proc. Natl. Acad. Sci. U.S.A. 74:2256-2258(1977) [PubMed] [Europe PMC] [Abstract]
  8. "Primary structure of human platelet factor 4."Thromb. Res. 11:893-898(1977) [PubMed] [Europe PMC] [Abstract]
  9. "Complete covalent structure of human platelet factor 4."Thromb. Haemost. 42:1652-1660(1980) [PubMed] [Europe PMC] [Abstract]
  10. "A potent inhibitor of endothelial cell proliferation is generated by proteolytic cleavage of the chemokine platelet factor 4."Proc. Natl. Acad. Sci. U.S.A. 92:7799-7803(1995) [PubMed] [Europe PMC] [Abstract]
  11. "Alternative C-terminal helix orientation alters chemokine function: Structure of the Anti-angiogenic Chemokine, CXCL4L1."J. Biol. Chem. 288:13522-13533(2013) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structure of recombinant human platelet factor 4."Biochemistry 33:8361-8366(1994) [PubMed] [Europe PMC] [Abstract]
  13. "NMR solution structure of the 32-kDa platelet factor 4 ELR-motif N-terminal chimera: a symmetric tetramer."Biochemistry 34:11399-11409(1995) [PubMed] [Europe PMC] [Abstract]