Platelet Factor 4 (PF4)

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CXCL4; SCYB4; Chemokine C-X-C-Motif Ligand 4; Oncostatin-A; Iroplact

Platelet Factor 4 (PF4)

Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family. This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin-like molecules. Due to these roles, it is predicted to play a role in wound repair and inflammation. It is usually found in a complex with proteoglycan.PF4 is chemotactic for neutrophils, fibroblasts and monocytes, and interacts with a splice variant of the chemokine receptor CXCR3, known as CXCR3B. PF4 is the antigen in heparin-induced thrombocytopenia, an idiosyncratic autoimmune reaction to the administration of the anticoagulant heparin. PF4 autoantibodies have also been found in patients with thrombosis and features resembling HIT but no prior administration of heparin.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA172Hu01Recombinant Platelet Factor 4 (PF4)Positive Control; Immunogen; SDS-PAGE; WB.
APA172Hu01Active Platelet Factor 4 (PF4)Cell culture; Activity Assays.
AntibodiesPAA172Hu01Polyclonal Antibody to Platelet Factor 4 (PF4)WB; IHC; ICC; IP.
MAA172Hu22Monoclonal Antibody to Platelet Factor 4 (PF4)WB; IHC; ICC; IP.
LAA172Hu71Biotin-Linked Polyclonal Antibody to Platelet Factor 4 (PF4)WB; IHC; ICC.
LAA172Hu81FITC-Linked Polyclonal Antibody to Platelet Factor 4 (PF4)WB; IHC; ICC; IF.
Assay KitsSEA172HuELISA Kit for Platelet Factor 4 (PF4)Enzyme-linked immunosorbent assay for Antigen Detection.
SCA172HuCLIA Kit for Platelet Factor 4 (PF4)Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA172Mu01Recombinant Platelet Factor 4 (PF4)Positive Control; Immunogen; SDS-PAGE; WB.
RPA172Mu02Recombinant Platelet Factor 4 (PF4)Positive Control; Immunogen; SDS-PAGE; WB.
APA172Mu01Active Platelet Factor 4 (PF4)Cell culture; Activity Assays.
AntibodiesPAA172Mu01Polyclonal Antibody to Platelet Factor 4 (PF4)WB; IHC; ICC; IP.
PAA172Mu02Polyclonal Antibody to Platelet Factor 4 (PF4)WB; IHC; ICC; IP.
LAA172Mu71Biotin-Linked Polyclonal Antibody to Platelet Factor 4 (PF4)WB; IHC; ICC.
LAA172Mu81FITC-Linked Polyclonal Antibody to Platelet Factor 4 (PF4)WB; IHC; ICC; IF.
Assay KitsSEA172MuELISA Kit for Platelet Factor 4 (PF4)Enzyme-linked immunosorbent assay for Antigen Detection.
SCA172MuCLIA Kit for Platelet Factor 4 (PF4)Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA172Ra01Recombinant Platelet Factor 4 (PF4)Positive Control; Immunogen; SDS-PAGE; WB.
RPA172Ra02Recombinant Platelet Factor 4 (PF4)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAA172Ra01Polyclonal Antibody to Platelet Factor 4 (PF4)WB; IHC; ICC; IP.
LAA172Ra71Biotin-Linked Polyclonal Antibody to Platelet Factor 4 (PF4)WB; IHC; ICC.
LAA172Ra81FITC-Linked Polyclonal Antibody to Platelet Factor 4 (PF4)WB; IHC; ICC; IF.
PAA172Ra02Polyclonal Antibody to Platelet Factor 4 (PF4)WB; IHC; ICC; IP.
MAA172Ra21Monoclonal Antibody to Platelet Factor 4 (PF4)WB; IHC; ICC; IP.
Assay KitsSEA172RaELISA Kit for Platelet Factor 4 (PF4)Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA172Rb01Recombinant Platelet Factor 4 (PF4)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAA172Rb51Polyclonal Antibody to Platelet Factor 4 (PF4)WB; IHC; ICC; IP.
MAA172Rb21Monoclonal Antibody to Platelet Factor 4 (PF4)WB; IHC; ICC; IP.
Assay KitsSEA172RbELISA Kit for Platelet Factor 4 (PF4)Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA172Po01Recombinant Platelet Factor 4 (PF4)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAA172Po01Polyclonal Antibody to Platelet Factor 4 (PF4)WB; IHC; ICC; IP.
MAA172Po21Monoclonal Antibody to Platelet Factor 4 (PF4)WB; IHC; ICC; IP.
Assay KitsSEA172PoELISA Kit for Platelet Factor 4 (PF4)Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA172Bo01Recombinant Platelet Factor 4 (PF4)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAA172Bo01Polyclonal Antibody to Platelet Factor 4 (PF4)WB; IHC; ICC; IP.
MAA172Bo21Monoclonal Antibody to Platelet Factor 4 (PF4)WB; IHC; ICC; IP.
Assay KitsSEA172BoELISA Kit for Platelet Factor 4 (PF4)Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA172Cp01Recombinant Platelet Factor 4 (PF4)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAA172Cp01Polyclonal Antibody to Platelet Factor 4 (PF4)WB; IHC; ICC; IP.
Assay Kitsn/aCLIA Kit for Platelet Factor 4 (PF4)CLIA Kit Customized Service Offer
n/aELISA Kit for Platelet Factor 4 (PF4)ELISA Kit Customized Service Offer

Organism species: Equus caballus; Equine (Horse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA172Eq01Recombinant Platelet Factor 4 (PF4)Positive Control; Immunogen; SDS-PAGE; WB.
Antibodiesn/aMonoclonal Antibody to Platelet Factor 4 (PF4)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Platelet Factor 4 (PF4)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Platelet Factor 4 (PF4)CLIA Kit Customized Service Offer
n/aELISA Kit for Platelet Factor 4 (PF4)ELISA Kit Customized Service Offer
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  8. "Primary structure of human platelet factor 4."Thromb. Res. 11:893-898(1977) [PubMed] [Europe PMC] [Abstract]
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  10. "A potent inhibitor of endothelial cell proliferation is generated by proteolytic cleavage of the chemokine platelet factor 4."Proc. Natl. Acad. Sci. U.S.A. 92:7799-7803(1995) [PubMed] [Europe PMC] [Abstract]
  11. "Alternative C-terminal helix orientation alters chemokine function: Structure of the Anti-angiogenic Chemokine, CXCL4L1."J. Biol. Chem. 288:13522-13533(2013) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structure of recombinant human platelet factor 4."Biochemistry 33:8361-8366(1994) [PubMed] [Europe PMC] [Abstract]
  13. "NMR solution structure of the 32-kDa platelet factor 4 ELR-motif N-terminal chimera: a symmetric tetramer."Biochemistry 34:11399-11409(1995) [PubMed] [Europe PMC] [Abstract]