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Laminin Beta 1 (LAMb1)

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LAM-B1; CLM; Cutis Laxa With Marfanoid Phenotype

Laminin Beta 1 (LAMb1)
CCC A184
HGNC 6486
MGI 96743
PubMed 23472759
RGD 1306311
UniProt P07942
Wiki LAMB1
Laminin subunit beta-1 is the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor.
A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA184Hu01 Recombinant Laminin Beta 1 (LAMb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA184Hu01 Polyclonal Antibody to Laminin Beta 1 (LAMb1) WB; IHC; ICC; IP.
MAA184Hu22 Monoclonal Antibody to Laminin Beta 1 (LAMb1) WB; IHC; ICC; IP.
MAA184Hu21 Monoclonal Antibody to Laminin Beta 1 (LAMb1) WB; IHC; ICC; IP.
Assay Kits SEA184Hu ELISA Kit for Laminin Beta 1 (LAMb1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA184Mu01 Recombinant Laminin Beta 1 (LAMb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA184Mu01 Polyclonal Antibody to Laminin Beta 1 (LAMb1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Laminin Beta 1 (LAMb1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Laminin Beta 1 (LAMb1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA184Ra01 Recombinant Laminin Beta 1 (LAMb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA184Ra01 Polyclonal Antibody to Laminin Beta 1 (LAMb1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Laminin Beta 1 (LAMb1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Laminin Beta 1 (LAMb1) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Laminin Beta 1 (LAMb1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Laminin Beta 1 (LAMb1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Laminin Beta 1 (LAMb1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Laminin Beta 1 (LAMb1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Laminin Beta 1 (LAMb1) ELISA Kit Customized Service Offer
  1. "Structure of the human laminin B1 chain gene."J. Biol. Chem. 265:15611-15616(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Human laminin B1 chain. A multidomain protein with gene (LAMB1) locus in the q22 region of chromosome 7."J. Biol. Chem. 262:10454-10462(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Isolation of a cDNA clone for the human laminin-B1 chain and its gene localization."Am. J. Hum. Genet. 41:605-615(1987) [PubMed] [Europe PMC] [Abstract]
  6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Mutations in LAMB1 cause cobblestone brain malformation without muscular or ocular abnormalities."Am. J. Hum. Genet. 92:468-474(2013) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]