Glycoprotein IX, Platelet (GP9)

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CD42-A; CD42a; GPIX; Glycoprotein 9

Glycoprotein IX, Platelet (GP9)

Glycoprotein IX (platelet) (GP9) also known as CD42a (Cluster of Differentiation 42a), is a human gene. Platelet glycoprotein IX (GP9) is a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib (GP Ib), a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor (VWF) (known as the Glycoprotein Ib-IX-V Receptor Complex). The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA) and a beta chain (GP1BB), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with GP9 and platelet glycoprotein V (GP5).

 

 

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Glycoprotein IX, Platelet (GP9)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Glycoprotein IX, Platelet (GP9)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Glycoprotein IX, Platelet (GP9)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Glycoprotein IX, Platelet (GP9)CLIA Kit Customized Service Offer
n/aELISA Kit for Glycoprotein IX, Platelet (GP9)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Glycoprotein IX, Platelet (GP9)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Glycoprotein IX, Platelet (GP9)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Glycoprotein IX, Platelet (GP9)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Glycoprotein IX, Platelet (GP9)CLIA Kit Customized Service Offer
n/aELISA Kit for Glycoprotein IX, Platelet (GP9)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA197Ra01Recombinant Glycoprotein IX, Platelet (GP9)SDS-PAGE; WB; ELISA; IP.
RPA197Ra02Recombinant Glycoprotein IX, Platelet (GP9)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA197Ra01Polyclonal Antibody to Glycoprotein IX, Platelet (GP9)WB, ICC, IHC-P, IHC-F, ELISA
PAA197Ra02Polyclonal Antibody to Glycoprotein IX, Platelet (GP9)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Glycoprotein IX, Platelet (GP9)CLIA Kit Customized Service Offer
n/aELISA Kit for Glycoprotein IX, Platelet (GP9)ELISA Kit Customized Service Offer
  1. "Human platelet glycoprotein IX. Characterization of cDNA and localization of the gene to chromosome 3."FEBS Lett. 274:189-192(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of the gene encoding human platelet glycoprotein IX."J. Biol. Chem. 268:3438-3443(1993) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human platelet glycoprotein IX: an adhesive prototype of leucine-rich glycoproteins with flank-center-flank structures."Proc. Natl. Acad. Sci. U.S.A. 86:6773-6777(1989) [PubMed] [Europe PMC] [Abstract]
  5. "Corrected DNA sequence of the platelet glycoprotein IX gene."Thromb. Haemost. 77:1034-1035(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Isolation and characterization of human platelet glycoprotein IX."Biochem. Biophys. Res. Commun. 156:931-939(1988) [PubMed] [Europe PMC] [Abstract]
  7. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Double heterozygosity for mutations in the platelet glycoprotein IX gene in three siblings with Bernard-Soulier syndrome."Blood 81:2339-2347(1993) [PubMed] [Europe PMC] [Abstract]
  9. "A phenylalanine-55 to serine amino-acid substitution in the human glycoprotein IX leucine-rich repeat is associated with Bernard-Soulier syndrome."Br. J. Haematol. 97:312-320(1997) [PubMed] [Europe PMC] [Abstract]
  10. "A new variant of Bernard-Soulier syndrome characterized by dysfunctional glycoprotein (GP) Ib and severely reduced amounts of GPIX and GPV."Br. J. Haematol. 103:1004-1013(1998) [PubMed] [Europe PMC] [Abstract]
  11. "Cys97-->Tyr mutation in the glycoprotein IX gene associated with Bernard-Soulier syndrome."Br. J. Haematol. 107:539-545(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Identification of a new mutation in platelet glycoprotein IX (GPIX) in a patient with Bernard-Soulier syndrome."Br. J. Haematol. 112:105-108(2001) [PubMed] [Europe PMC] [Abstract]
  13. "A novel point mutation in the transmembrane domain of platelet glycoprotein IX gene identified in a Bernard-Soulier syndrome patient."Zhonghua Xue Ye Xue Za Zhi 22:464-466(2001) [PubMed] [Europe PMC] [Abstract]
  14. "A Leu7-to-Pro mutation in the signal peptide of platelet glycoprotein (GP)IX in a case of Bernard-Soulier syndrome abolishes surface expression of the GPIb-V-IX complex."Br. J. Haematol. 118:260-266(2002) [PubMed] [Europe PMC] [Abstract]