Deoxyribonuclease I Like Protein 2 (DNASE1L2)

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DNAS1L2; DHP1; DNase I Homolog Protein DHP1; DNase I-like 2

Deoxyribonuclease I Like Protein 2 (DNASE1L2)

Germino et al. (1992) identified a DNASE1L2 exon while sequencing a cosmid from the PKD1 region on 16p13.3. Using the sequence of this exon for RT-PCR and searches of EST databases, Rodriguez et al. (1997) cloned DNASE1L2 cDNAs. The predicted 299-amino acid DNASE1L2 protein contains a 21-amino acid signal peptide. The amino acid sequence of DNASE1L2 is 56% identical to that of DNASE1. By RT-PCR, the authors detected DNASE1L2 expression in fetal and adult brain. Using RT-PCR, Shiokawa et al. (2004) detected DNASE1L2 expression in all tissues examined except colon. Peripheral blood leukocytes showed a second DNASE1L2 transcript, and by PCR of a leukocyte cDNA library, Shiokawa et al. (2004) cloned this splice variant, which they called DNASE1L2S.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Deoxyribonuclease I Like Protein 2 (DNASE1L2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Deoxyribonuclease I Like Protein 2 (DNASE1L2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Deoxyribonuclease I Like Protein 2 (DNASE1L2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Deoxyribonuclease I Like Protein 2 (DNASE1L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Deoxyribonuclease I Like Protein 2 (DNASE1L2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA202Mu01 Recombinant Deoxyribonuclease I Like Protein 2 (DNASE1L2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA202Mu01 Polyclonal Antibody to Deoxyribonuclease I Like Protein 2 (DNASE1L2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Deoxyribonuclease I Like Protein 2 (DNASE1L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Deoxyribonuclease I Like Protein 2 (DNASE1L2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA202Ra01 Recombinant Deoxyribonuclease I Like Protein 2 (DNASE1L2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA202Ra01 Polyclonal Antibody to Deoxyribonuclease I Like Protein 2 (DNASE1L2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Deoxyribonuclease I Like Protein 2 (DNASE1L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Deoxyribonuclease I Like Protein 2 (DNASE1L2) ELISA Kit Customized Service Offer
  1. "Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I."Genomics 42:507-513(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of the human DNAS1L2 gene and the molecular mechanism for its transcriptional activation induced by inflammatory cytokines."Genomics 84:95-105(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "DNase1L2 degrades nuclear DNA during corneocyte formation."J. Invest. Dermatol. 127:24-30(2007) [PubMed] [Europe PMC] [Abstract]