Prokineticin Receptor 1 (PKR1)

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PROKR1; PKR-1; GPR73; GPR-73a; ZAQ; PK-R1; G Protein-Coupled Receptor 73; G-protein coupled receptor ZAQ

Prokineticin Receptor 1 (PKR1)

The prokineticin receptor is a G-protein coupled receptor which binds the peptide hormone prokineticin. These receptors mediate gastrointestinal smooth muscle contraction and angiogenesis. There are two variants each encoded by a different gene. Prokineticin receptor 1 (also known as PKR1, or GPR73A), is encoded by the PROKR1 gene. GPR73A is a receptor for prokineticin 1. It is a member of the GPCR family and is coupled to the G(q) subclass of heteromeric G proteins. Activation of the receptor leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. GPR73A expression has been reported in adrenal, peripheral blood leukocytes, brain, colon, pancreas, prostate, rectum, salivary gland, small intestine, spleen, stomach, testis, and thyroid.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA203Hu01Recombinant Prokineticin Receptor 1 (PKR1)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAA203Hu01Polyclonal Antibody to Prokineticin Receptor 1 (PKR1)WB; IHC; ICC; IP.
MAA203Hu22Monoclonal Antibody to Prokineticin Receptor 1 (PKR1)WB; IHC; ICC; IP.
Assay KitsSEA203HuELISA Kit for Prokineticin Receptor 1 (PKR1)Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA203Mu01Recombinant Prokineticin Receptor 1 (PKR1)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAA203Mu01Polyclonal Antibody to Prokineticin Receptor 1 (PKR1)WB; IHC; ICC; IP.
Assay Kitsn/aCLIA Kit for Prokineticin Receptor 1 (PKR1)CLIA Kit Customized Service Offer
n/aELISA Kit for Prokineticin Receptor 1 (PKR1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA203Ra01Recombinant Prokineticin Receptor 1 (PKR1)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAA203Ra01Polyclonal Antibody to Prokineticin Receptor 1 (PKR1)WB; IHC; ICC; IP.
Assay Kitsn/aCLIA Kit for Prokineticin Receptor 1 (PKR1)CLIA Kit Customized Service Offer
n/aELISA Kit for Prokineticin Receptor 1 (PKR1)ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA203Bo01Recombinant Prokineticin Receptor 1 (PKR1)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAA203Bo01Polyclonal Antibody to Prokineticin Receptor 1 (PKR1)WB; IHC; ICC; IP.
Assay Kitsn/aCLIA Kit for Prokineticin Receptor 1 (PKR1)CLIA Kit Customized Service Offer
n/aELISA Kit for Prokineticin Receptor 1 (PKR1)ELISA Kit Customized Service Offer
  1. "Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors."Biochem. Biophys. Res. Commun. 293:396-402(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and characterization of prokineticin receptors."Biochim. Biophys. Acta 1579:173-179(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor."J. Biol. Chem. 277:19276-19280(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Prokineticin 1 signaling and gene regulation in early human pregnancy."Endocrinology 149:2877-2887(2008) [PubMed] [Europe PMC] [Abstract]