Triggering Receptor Expressed On Myeloid Cells 1 (TREM1)

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CD354; Triggering Receptor Expressed On Monocytes-1

Triggering Receptor Expressed On Myeloid Cells 1 (TREM1)

TREM-1 is a Type I membrane protein that contains an immunoglobulin-like V-type domain. An alternatively spliced protein variant may be secreted. TREM-1 is expressed in monocytes and neutrophils but not in lymphocytes, dendritic cells or other cell types. TREM1 expression can be further upregulated by bacteria, fungi and lipopolysaccharide. TREM-1 is a glycoprotein that is reduced by deglycosylation, in agreement with the predicted molecular mass. TREM-1 is an activating receptor of the Ig superfamily that is highly expressed on peripheral blood myeloid cells (particularly mature monocytes and granulocytes). TREM1 has been shown to interact with the adaptor protein DAP12 to stimulate neutrophil and monocyte-mediated inflammatory responses through the triggering and release of pro-inflammatory cytokines and chemokines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA213Hu01 Recombinant Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Positive Control; Immunogen; SDS-PAGE; WB.
EPA213Hu61 Eukaryotic Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Positive Control; Immunogen; SDS-PAGE; WB.
APA213Hu61 Active Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Cell culture; Activity Assays.
Antibodies PAA213Hu01 Polyclonal Antibody to Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) WB; IHC; ICC; IP.
MAA213Hu22 Monoclonal Antibody to Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) WB; IHC; ICC; IP.
Assay Kits SEA213Hu ELISA Kit for Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA213Hu CLIA Kit for Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA213Mu01 Recombinant Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA213Mu02 Recombinant Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA213Mu01 Polyclonal Antibody to Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) WB; IHC; ICC; IP.
PAA213Mu02 Polyclonal Antibody to Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) WB; IHC; ICC; IP.
Assay Kits SEA213Mu ELISA Kit for Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA213Ra01 Recombinant Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA213Ra01 Polyclonal Antibody to Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA213Po01 Recombinant Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA213Po01 Polyclonal Antibody to Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) WB; IHC; ICC; IP.
MAA213Po21 Monoclonal Antibody to Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) WB; IHC; ICC; IP.
LAA213Po71 Biotin-Linked Polyclonal Antibody to Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) WB; IHC; ICC.
Assay Kits SEA213Po ELISA Kit for Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA213Bo01 Recombinant Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA213Bo01 Polyclonal Antibody to Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Triggering Receptor Expressed On Myeloid Cells 1 (TREM1) ELISA Kit Customized Service Offer
  1. "Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes."J. Immunol. 164:4991-4995(2000) [PubMed] [Europe PMC] [Abstract]
  2. "TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development."Mol. Immunol. 38:817-824(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "TREM-1 amplifies inflammation and is a crucial mediator of septic shock."Nature 410:1103-1107(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Crystal structure of the human myeloid cell activating receptor TREM-1."Structure 11:1527-1535(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A."J. Mol. Biol. 342:1237-1248(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]