Monocyte Chemotactic Protein 4 (MCP4)

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CCL13; SCYA13; NCC1; SCYL1; CKb10; Chemokine C-C-Motif Ligand 13; Small Inducible Cytokine Subfamily A(Cys-Cys)Member 13; CK-beta-10; Monocyte chemoattractant 4

Monocyte Chemotactic Protein 4 (MCP4)

Chemokine (C-C motif) ligand 13 (CCL13) is a small cytokine belonging to the CC chemokine family.The chemokines are secreted proteins involved in immunoregulatory and inflammatory processes. Naruse et al. (1996) identified on chromosome 17q11.2 a cluster of chemokines from the CC family (characterized by a cys-cys sequence motif) and distinguished from a second chemokine family that features a cys-xxx-cys (CXC) motif . They mapped 1 gene of the CC family (called NCC1 by them) to the cluster using a panel of somatic cell hybrids with known deletions. NCC1 was originally characterized as an expressed sequence tag (EST). The deduced order of genes from a YAC contig assembled for the region is cen--NF1--MCP3, MCP1, NCC1, I-309--Y1741 breakpoint--RANTES--LD78-gamma, AT744.2 , LD78-beta --NCC3, NCC2, AT744.1 ), LD78-alpha--NCC4--RARA --tel.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA216Hu01Recombinant Monocyte Chemotactic Protein 4 (MCP4)SDS-PAGE; WB; ELISA; IP.
EPA216Hu51Eukaryotic Monocyte Chemotactic Protein 4 (MCP4)SDS-PAGE; WB; ELISA; IP; CoIP; EMSA; Reporter Assays; Purification; Amine Reactive Labeling.
APA216Hu51Active Monocyte Chemotactic Protein 4 (MCP4)Cell culture; Activity Assays; In vivo assays.
APA216Hu01Active Monocyte Chemotactic Protein 4 (MCP4)Cell culture; Activity Assays; In vivo assays.
AntibodiesPAA216Hu01Polyclonal Antibody to Monocyte Chemotactic Protein 4 (MCP4)WB, ICC, IHC-P, IHC-F, ELISA
MAA216Hu22Monoclonal Antibody to Monocyte Chemotactic Protein 4 (MCP4)WB, ICC, IHC-P, IHC-F, ELISA
PAA216Hu51Polyclonal Antibody to Monocyte Chemotactic Protein 4 (MCP4)WB, ICC, IHC-P, IHC-F, ELISA
PAA216Hu02Polyclonal Antibody to Monocyte Chemotactic Protein 4 (MCP4)WB, ICC, IHC-P, IHC-F, ELISA
PAA216Hu07Polyclonal Antibody to Monocyte Chemotactic Protein 4 (MCP4)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Monocyte Chemotactic Protein 4 (MCP4)CLIA Kit Customized Service Offer
n/aELISA Kit for Monocyte Chemotactic Protein 4 (MCP4)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Monocyte Chemotactic Protein 4 (MCP4)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Monocyte Chemotactic Protein 4 (MCP4)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Monocyte Chemotactic Protein 4 (MCP4)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Monocyte Chemotactic Protein 4 (MCP4)CLIA Kit Customized Service Offer
n/aELISA Kit for Monocyte Chemotactic Protein 4 (MCP4)ELISA Kit Customized Service Offer

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA216Ca01Recombinant Monocyte Chemotactic Protein 4 (MCP4)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA216Ca01Polyclonal Antibody to Monocyte Chemotactic Protein 4 (MCP4)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Monocyte Chemotactic Protein 4 (MCP4)CLIA Kit Customized Service Offer
n/aELISA Kit for Monocyte Chemotactic Protein 4 (MCP4)ELISA Kit Customized Service Offer

Organism species: Equus caballus; Equine (Horse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA216Eq01Recombinant Monocyte Chemotactic Protein 4 (MCP4)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA216Eq01Polyclonal Antibody to Monocyte Chemotactic Protein 4 (MCP4)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Monocyte Chemotactic Protein 4 (MCP4)CLIA Kit Customized Service Offer
n/aELISA Kit for Monocyte Chemotactic Protein 4 (MCP4)ELISA Kit Customized Service Offer
  1. "Cloning and characterization of MCP-4, a novel CC chemokine related to MCP-1 and eotaxin."Eur. Cytokine Netw. 7:513-513(1996)
  2. "Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3."J. Immunol. 157:5613-5626(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin."J. Exp. Med. 183:2379-2384(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemotactic protein (MCP) family (MCP-4) that binds and signals through the CC chemokine receptor 2B."J. Biol. Chem. 272:16404-16413(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Monocyte chemotactic protein-4: tissue-specific expression and signaling through CC chemokine receptor-2."J. Leukoc. Biol. 61:353-360(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Genomic organization, sequence analysis and transcriptional regulation of the human MCP-4 chemokine gene (SCYA13) in dermal fibroblasts: a comparison to other eosinophilic beta-chemokines."Biochem. Biophys. Res. Commun. 255:470-476(1999) [PubMed] [Europe PMC] [Abstract]
  7. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Structure of human monocyte chemoattractant protein 4 (MCP-4/CCL13)."Acta Crystallogr. D 64:273-278(2008) [PubMed] [Europe PMC] [Abstract]