Prostaglandin F Receptor (FP)

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PTGFR; Prostaglandin F2-alpha receptor; Prostanoid FP receptor

Prostaglandin F Receptor (FP)

Prostaglandin F(2-alpha) is involved in a number of physiologic processes. It serves as a potent luteolytic agent in many species, has been implicated as a modulator of intraocular pressure, and may be important in smooth muscle contraction in the uterus and elsewhere. Its effects on cells are mediated through specific interaction with prostaglandin receptors. Abramovitz et al. (1994) cloned a cDNA encoding the human prostanoid FP receptor from a uterus cDNA library. The 359-amino acid protein has 7 putative transmembrane domains characteristic of the G protein-coupled receptors. As expected, expression studies of the cDNA in Xenopus oocytes and COS cells showed strongest binding to PGF(2-alpha).Betz et al. (1999) showed that the human PTGFR gene consists of 3 exons spanning approximately 10 kb of genomic DNA.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prostaglandin F Receptor (FP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prostaglandin F Receptor (FP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prostaglandin F Receptor (FP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prostaglandin F Receptor (FP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prostaglandin F Receptor (FP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prostaglandin F Receptor (FP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prostaglandin F Receptor (FP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prostaglandin F Receptor (FP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prostaglandin F Receptor (FP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prostaglandin F Receptor (FP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prostaglandin F Receptor (FP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prostaglandin F Receptor (FP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prostaglandin F Receptor (FP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prostaglandin F Receptor (FP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prostaglandin F Receptor (FP) ELISA Kit Customized Service Offer
  1. "Cloning and expression of a cDNA for the human prostanoid FP receptor."J. Biol. Chem. 269:2632-2636(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha."J. Biol. Chem. 272:27147-27154(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and localization of hFP(S): a six-transmembrane mRNA splice variant of the human FP prostanoid receptor."Arch. Biochem. Biophys. 421:175-185(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Identification and pharmacological characterization of the prostaglandin FP receptor and FP receptor variant complexes."Br. J. Pharmacol. 154:1079-1093(2008) [PubMed] [Europe PMC] [Abstract]