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Thyroxine Binding Globulin (TBG)

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SERPINA7; Serpin Peptidase Inhibitor Clade A Member 7; T4-binding globulin

Thyroxine Binding Globulin (TBG)
CCC A305
HGNC 11583
MGI 3041197
PubMed 8232304
RGD 619833
UniProt P05543
Wiki SERPINA7

Thyroxine-binding globulin (TBG) binds Thyroid hormone in circulation. It is one of three proteins (along with transthyretin and albumin) responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3’-triiodothyronine (T3) in the bloodstream. Of these three proteins, TBG has the highest affinity for T4 and T3, but is present in the lowest concentration. Despite its low concentration, TBG carries the majority of T4 in serum. Due to the very low serum concentration of T4 & T3, TBG is rarely more than 25% saturated with its ligand. Unlike transthyretin and albumin, TBG has a single binding site for T4/T3. TBG is synthesized primarily in the liver as a 54 kDa protein. Genomically, TBG is a serpin, although it has no inhibitory function like many other members of this class of proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA305Hu01 Recombinant Thyroxine Binding Globulin (TBG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA305Hu01 Polyclonal Antibody to Thyroxine Binding Globulin (TBG) WB; IHC; ICC/IF
MAA305Hu22 Monoclonal Antibody to Thyroxine Binding Globulin (TBG) WB; IHC; ICC; IP.
LAA305Hu81 FITC-Linked Polyclonal Antibody to Thyroxine Binding Globulin (TBG) WB; IHC; ICC; IF.
LAA305Hu71 Biotin-Linked Polyclonal Antibody to Thyroxine Binding Globulin (TBG) WB; IHC; ICC.
Assay Kits SEA305Hu ELISA Kit for Thyroxine Binding Globulin (TBG) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA305Hu CLIA Kit for Thyroxine Binding Globulin (TBG) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA305Mu01 Recombinant Thyroxine Binding Globulin (TBG) Positive Control; Immunogen; SDS-PAGE; WB.
RPA305Mu02 Recombinant Thyroxine Binding Globulin (TBG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA305Mu01 Polyclonal Antibody to Thyroxine Binding Globulin (TBG) WB; IHC; ICC; IP.
PAA305Mu02 Polyclonal Antibody to Thyroxine Binding Globulin (TBG) WB; IHC; ICC; IP.
Assay Kits SEA305Mu ELISA Kit for Thyroxine Binding Globulin (TBG) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA305Ra01 Recombinant Thyroxine Binding Globulin (TBG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA305Ra01 Polyclonal Antibody to Thyroxine Binding Globulin (TBG) WB; IHC; ICC; IP.
Assay Kits SEA305Ra ELISA Kit for Thyroxine Binding Globulin (TBG) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "The structure of the human thyroxine binding globulin (TBG) gene."Biochim. Biophys. Acta 1216:446-454(1993) [PubMed] [Europe PMC] [Abstract]
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  11. "Molecular basis of inherited thyroxine-binding globulin defects."Trends Endocrinol. Metab. 3:49-53(1992) [PubMed] [Europe PMC] [Abstract]
  12. "Replacement of Leu227 by Pro in thyroxine-binding globulin (TBG) is associated with complete TBG deficiency in three of eight families with this inherited defect."J. Clin. Endocrinol. Metab. 70:804-809(1990) [PubMed] [Europe PMC] [Abstract]
  13. "A mutation causing reduced biological activity and stability of thyroxine-binding globulin probably as a result of abnormal glycosylation of the molecule."Mol. Endocrinol. 3:575-579(1989) [PubMed] [Europe PMC] [Abstract]
  14. "Thyroxine-binding globulin variant (TBG-Kumamoto): identification of a point mutation and genotype analysis of its family."Endocrinol. Jpn. 39:577-584(1992) [PubMed] [Europe PMC] [Abstract]
  15. "Sequence of the variant thyroxine-binding globulin (TBG) in a Montreal family with partial TBG deficiency."Hum. Genet. 87:119-122(1991) [PubMed] [Europe PMC] [Abstract]
  16. "Sequencing of the variant thyroxine-binding globulin (TBG)-Quebec reveals two nucleotide substitutions."Am. J. Hum. Genet. 48:741-744(1991) [PubMed] [Europe PMC] [Abstract]
  17. "Sequencing of the variant thyroxine-binding globulin (TBG)-San Diego reveals two nucleotide substitutions."Biochim. Biophys. Acta 1139:307-310(1992) [PubMed] [Europe PMC] [Abstract]
  18. "Sequence of the variant thyroxine-binding globulin of Australian aborigines. Only one of two amino acid replacements is responsible for its altered properties."J. Clin. Invest. 83:1344-1348(1989) [PubMed] [Europe PMC] [Abstract]
  19. "Molecular basis for the properties of the thyroxine-binding globulin-slow variant in American blacks."J. Endocrinol. Invest. 13:343-349(1990) [PubMed] [Europe PMC] [Abstract]