Neutrophil Cytosolic Factor 4 (NCF4)

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NCF; P40PHOX; SH3PXD4; Neutrophil NADPH Oxidase Factor 4; SH3 and PX domain-containing protein 4

Neutrophil Cytosolic Factor 4 (NCF4)

Neutrophil cytosol factor 4 is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA328Hu01Recombinant Neutrophil Cytosolic Factor 4 (NCF4)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA328Hu01Polyclonal Antibody to Neutrophil Cytosolic Factor 4 (NCF4)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Neutrophil Cytosolic Factor 4 (NCF4)CLIA Kit Customized Service Offer
n/aELISA Kit for Neutrophil Cytosolic Factor 4 (NCF4)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA328Mu01Recombinant Neutrophil Cytosolic Factor 4 (NCF4)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA328Mu01Polyclonal Antibody to Neutrophil Cytosolic Factor 4 (NCF4)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Neutrophil Cytosolic Factor 4 (NCF4)CLIA Kit Customized Service Offer
n/aELISA Kit for Neutrophil Cytosolic Factor 4 (NCF4)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Neutrophil Cytosolic Factor 4 (NCF4)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Neutrophil Cytosolic Factor 4 (NCF4)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Neutrophil Cytosolic Factor 4 (NCF4)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Neutrophil Cytosolic Factor 4 (NCF4)CLIA Kit Customized Service Offer
n/aELISA Kit for Neutrophil Cytosolic Factor 4 (NCF4)ELISA Kit Customized Service Offer
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  9. "The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate."Mol. Cell 8:829-839(2001) [PubMed] [Europe PMC] [Abstract]
  10. "PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62."Mol. Cell 12:39-50(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Effects of p47phox C terminus phosphorylations on binding interactions with p40phox and p67phox. Structural and functional comparison of p40phox and p67phox SH3 domains."J. Biol. Chem. 280:13752-13761(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Full-length p40phox structure suggests a basis for regulation mechanism of its membrane binding."EMBO J. 26:1176-1186(2007) [PubMed] [Europe PMC] [Abstract]
  13. "A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40 phox and selective defects in neutrophil NADPH oxidase activity."Blood 114:3309-3315(2009) [PubMed] [Europe PMC] [Abstract]