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Platelet/Endothelial Cell Adhesion Molecule (PECAM1)

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CD31; EndoCAM; GPIIA'; PECA1

Platelet/Endothelial Cell Adhesion Molecule (PECAM1)
CCC A363
HGNC 8823
MGI 97537
PubMed 7956830
RGD 61927
UniProt P16284
Wiki CD31

CD31 is a cluster of differentiation molecule. It is also called PECAM-1 for platelet endothelial cell adhesion molecule. It plays a key role in removing aged neutrophils from the body. Macrophages palpate any passing neutrophil and have to decide whether the cell is healthy or has to be ingested. In humans, the gene encoding CD-31 is found on chromosome 17.

If a neutrophil is dying, it will have phosphatidyl serine in its plasma membrane. Both the neutrophil and the macrophage express CD-31 on their membranes, and, during the testing process, these CD-31 molecules bind the two cells together. If the neutrophil is healthy, it will now fire a signal to the macrophage, and the CD-31 molecules will detach. The neutrophil is now free.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA363Hu01 Recombinant Platelet/Endothelial Cell Adhesion Molecule (PECAM1) Positive Control; Immunogen; SDS-PAGE; WB.
EPA363Hu61 Eukaryotic Platelet/Endothelial Cell Adhesion Molecule (PECAM1) Positive Control; Immunogen; SDS-PAGE; WB.
APA363Hu61 Active Platelet/Endothelial Cell Adhesion Molecule (PECAM1) Cell culture; Activity Assays.
RPA363Hu02 Recombinant Platelet/Endothelial Cell Adhesion Molecule (PECAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA363Hu01 Polyclonal Antibody to Platelet/Endothelial Cell Adhesion Molecule (PECAM1) WB; IHC; ICC; IP.
MAA363Hu22 Monoclonal Antibody to Platelet/Endothelial Cell Adhesion Molecule (PECAM1) WB; IHC; ICC; IP.
LAA363Hu71 Biotin-Linked Polyclonal Antibody to Platelet/Endothelial Cell Adhesion Molecule (PECAM1) WB; IHC; ICC.
Assay Kits SEA363Hu ELISA Kit for Platelet/Endothelial Cell Adhesion Molecule (PECAM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA363Mu01 Recombinant Platelet/Endothelial Cell Adhesion Molecule (PECAM1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA363Mu02 Recombinant Platelet/Endothelial Cell Adhesion Molecule (PECAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA363Mu01 Polyclonal Antibody to Platelet/Endothelial Cell Adhesion Molecule (PECAM1) WB; IHC; ICC; IP.
PAA363Mu02 Polyclonal Antibody to Platelet/Endothelial Cell Adhesion Molecule (PECAM1) WB; IHC; ICC; IP.
LAA363Mu71 Biotin-Linked Polyclonal Antibody to Platelet/Endothelial Cell Adhesion Molecule (PECAM1) WB; IHC; ICC.
Assay Kits SEA363Mu ELISA Kit for Platelet/Endothelial Cell Adhesion Molecule (PECAM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA363Ra01 Recombinant Platelet/Endothelial Cell Adhesion Molecule (PECAM1) Positive Control; Immunogen; SDS-PAGE; WB.
EPA363Ra61 Eukaryotic Platelet/Endothelial Cell Adhesion Molecule (PECAM1) Positive Control; Immunogen; SDS-PAGE; WB.
APA363Ra61 Active Platelet/Endothelial Cell Adhesion Molecule (PECAM1) Cell culture; Activity Assays.
Antibodies PAA363Ra01 Polyclonal Antibody to Platelet/Endothelial Cell Adhesion Molecule (PECAM1) WB; IHC; ICC; IP.
MAA363Ra21 Monoclonal Antibody to Platelet/Endothelial Cell Adhesion Molecule (PECAM1) WB; IHC; ICC; IP.
Assay Kits SEA363Ra ELISA Kit for Platelet/Endothelial Cell Adhesion Molecule (PECAM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Platelet/Endothelial Cell Adhesion Molecule (PECAM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Platelet/Endothelial Cell Adhesion Molecule (PECAM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Platelet/Endothelial Cell Adhesion Molecule (PECAM1) Polyclonal Antibody Customized Service Offer
Assay Kits SEA363Po ELISA Kit for Platelet/Endothelial Cell Adhesion Molecule (PECAM1) Enzyme-linked immunosorbent assay for Antigen Detection.
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  9. "Identification of PECAM-1 in solid tumor cells and its potential involvement in tumor cell adhesion to endothelium."J. Biol. Chem. 268:22883-22894(1993) [PubMed] [Europe PMC] [Abstract]
  10. "Tyrosine residue in exon 14 of the cytoplasmic domain of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) regulates ligand binding specificity."J. Cell Biol. 138:1425-1435(1997) [PubMed] [Europe PMC] [Abstract]
  11. "Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment."Nature 418:200-203(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Tissue-specific distributions of alternatively spliced human PECAM-1 isoforms."Am. J. Physiol. 284:H1008-H1017(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Palmitoylation at Cys595 is essential for PECAM-1 localisation into membrane microdomains and for efficient PECAM-1-mediated cytoprotection."Thromb. Haemost. 96:756-766(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Regulation of G protein-coupled receptor activities by the platelet-endothelial cell adhesion molecule, PECAM-1."Biochemistry 47:9029-9039(2008) [PubMed] [Europe PMC] [Abstract]
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  17. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  18. "A novel and critical role for tyrosine 663 in platelet endothelial cell adhesion molecule-1 trafficking and transendothelial migration."J. Immunol. 182:5041-5051(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases."Circ. Res. 110:1336-1344(2012) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  24. "Polymorphism of adhesion molecule CD31 and its role in acute graft-versus-host disease."N. Engl. J. Med. 334:286-291(1996) [PubMed] [Europe PMC] [Abstract]
  25. "Codon 125 polymorphism of CD31 and susceptibility to malaria."Am. J. Trop. Med. Hyg. 65:736-737(2001) [PubMed] [Europe PMC] [Abstract]