GATA Binding Protein 3 (GATA3)

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HDR; Trans-acting T-cell-specific transcription factor GATA-3

GATA Binding Protein 3 (GATA3)

Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all 4 TCR genes. GATA3 had been shown in the chicken to be an enhancer-binding protein containing a zinc finger domain. GATA3 mRNA was demonstrated by Northern blot analysis in T cells but not in B cells, macrophages, or HeLa cell lines. GATA3 was abundantly expressed in the T-lymphocyte lineage and was thought to participate in T-cell receptor gene activation through binding to enhancers. Labastie et al. (1994) cloned the human gene and the 5-prime end of the mouse gene. The 2 zinc fingers of GATA3 are encoded by 2 separate exons highly conserved with those of GATA1, but no other structural homologies between the 2 genes could be found.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA410Hu01Recombinant GATA Binding Protein 3 (GATA3)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA410Hu01Polyclonal Antibody to GATA Binding Protein 3 (GATA3)WB, ICC, IHC-P, IHC-F, ELISA
MAA410Hu22Monoclonal Antibody to GATA Binding Protein 3 (GATA3)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA410HuELISA Kit for GATA Binding Protein 3 (GATA3)Enzyme-linked immunosorbent assay

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant GATA Binding Protein 3 (GATA3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to GATA Binding Protein 3 (GATA3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to GATA Binding Protein 3 (GATA3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for GATA Binding Protein 3 (GATA3)CLIA Kit Customized Service Offer
n/aELISA Kit for GATA Binding Protein 3 (GATA3)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant GATA Binding Protein 3 (GATA3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to GATA Binding Protein 3 (GATA3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to GATA Binding Protein 3 (GATA3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for GATA Binding Protein 3 (GATA3)CLIA Kit Customized Service Offer
n/aELISA Kit for GATA Binding Protein 3 (GATA3)ELISA Kit Customized Service Offer
  1. "A T-cell specific TCR delta DNA binding protein is a member of the human GATA family."EMBO J. 10:1809-1816(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene."EMBO J. 10:1187-1192(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer."Mol. Cell. Biol. 11:2778-2784(1991) [PubMed] [Europe PMC] [Abstract]
  4. "The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements."Proc. Natl. Acad. Sci. U.S.A. 88:7284-7288(1991) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "GATA3 haplo-insufficiency causes human HDR syndrome."Nature 406:419-422(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Genome-wide gene expression profiling revealed a critical role for GATA3 in the maintenance of the Th2 cell identity."PLoS ONE 8:E66468-E66468(2013) [PubMed] [Europe PMC] [Abstract]
  10. "DNA binding by GATA transcription factor suggests mechanisms of DNA looping and long-range gene regulation."Cell Rep. 2:1197-1206(2012) [PubMed] [Europe PMC] [Abstract]
  11. "GATA3 abnormalities and the phenotypic spectrum of HDR syndrome."J. Med. Genet. 38:374-380(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas."Breast Cancer Res. 9:R5-R5(2007) [PubMed] [Europe PMC] [Abstract]