Plakophilin 2 (PKP2)
Plakophilin-2 is a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton.
This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA445Hu01Recombinant Plakophilin 2 (PKP2)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA445Hu01Polyclonal Antibody to Plakophilin 2 (PKP2)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Plakophilin 2 (PKP2)CLIA Kit Customized Service Offer
n/aELISA Kit for Plakophilin 2 (PKP2)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Plakophilin 2 (PKP2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Plakophilin 2 (PKP2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Plakophilin 2 (PKP2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Plakophilin 2 (PKP2)CLIA Kit Customized Service Offer
n/aELISA Kit for Plakophilin 2 (PKP2)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Plakophilin 2 (PKP2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Plakophilin 2 (PKP2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Plakophilin 2 (PKP2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Plakophilin 2 (PKP2)CLIA Kit Customized Service Offer
n/aELISA Kit for Plakophilin 2 (PKP2)ELISA Kit Customized Service Offer
  1. "Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque."J. Cell Biol. 135:1009-1025(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Desmosomal plakophilin 2 as a differentiation marker in normal and malignant tissues."Differentiation 64:277-290(1999) [PubMed] [Europe PMC] [Abstract]
  5. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations."Cardiovasc. Res. 90:77-87(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Plakophilin 2A is the dominant isoform in human heart tissue: consequences for the genetic screening of arrhythmogenic right ventricular cardiomyopathy."Heart 97:844-849(2011) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations."Circ. Cardiovasc. Genet. 5:400-411(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy."Nat. Genet. 36:1162-1164(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Comprehensive desmosome mutation analysis in North Americans with arrhythmogenic right ventricular dysplasia/cardiomyopathy."Circ. Cardiovasc. Genet. 2:428-435(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Missense variants in plakophilin-2 in arrhythmogenic right ventricular cardiomyopathy patients -- disease-causing or innocent bystanders?"Cardiology 115:148-154(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Role of genetic testing in arrhythmogenic right ventricular cardiomyopathy/dysplasia."Clin. Genet. 77:37-48(2010) [PubMed] [Europe PMC] [Abstract]