Keratin 3 (KRT3)

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CK3; K3; Cytokeratin 3; Keratin, type II cytoskeletal 3; 65 kDa cytokeratin; Type-II keratin Kb3

Keratin 3 (KRT3)
  • Specific pairs of heterotypic keratin chains are coexpressed during the various stages of epithelial differentiation. This pattern of expression of cytokeratin pairs implies the existence of highly coordinated control of transcription. The gene for cytokeratin 3 (KRT3), a member of the type II subfamily, is expressed together with KRT12  during 'corneal-type' differentiation (Schermer et al., 1986).

  • The KRT3 gene is approximately 6.5 kb long and encodes one of the largest cytokeratin proteins (64 kD). By fluorescence in situ hybridization, Raimondi et al. (1994) mapped the KRT3 gene to 12q12-q13. All type II keratin genes mapped to that time had been assigned to chromosome 12 where they appeared to be organized into one homotypic cluster.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA490Hu01Recombinant Keratin 3 (KRT3)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA490Hu01Polyclonal Antibody to Keratin 3 (KRT3)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Keratin 3 (KRT3)CLIA Kit Customized Service Offer
n/aELISA Kit for Keratin 3 (KRT3)ELISA Kit Customized Service Offer

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Keratin 3 (KRT3)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Keratin 3 (KRT3)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Keratin 3 (KRT3)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Keratin 3 (KRT3)CLIA Kit Customized Service Offer
n/aELISA Kit for Keratin 3 (KRT3)ELISA Kit Customized Service Offer
  1. "Evolution of keratin genes: different protein domains evolve by different pathways."J. Mol. Evol. 24:319-329(1987) [PubMed] [Europe PMC] [Abstract]
  2. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13."J. Invest. Dermatol. 124:536-544(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Mutations in cornea-specific keratin K3 or K12 genes cause Meesmann's corneal dystrophy."Nat. Genet. 16:184-187(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Novel mutations in the helix termination motif of keratin 3 and keratin 12 in 2 Taiwanese families with Meesmann corneal dystrophy."Cornea 24:928-932(2005) [PubMed] [Europe PMC] [Abstract]