Oxidized Low Density Lipoprotein (OxLDL)

Hypercholesterolemia is closely associated with increased risk of atherosclerosis. The cholesterol accumulated in the atherosclerotic plaque is derived primarily from low-density lipoprotein (LDL). Oxidation of LDL is now accepted as a critical event in the atherogenic process. Free radicals like superoxide and nitric oxide (-O2 , NO) generated in biological reactions in the body contribute to the oxidation of LDL. The NO radical has been shown to oxidize apolipoprotein B a constituant of LDL. Similarly, lipoxygenases and oxidants like peroxynitrite can oxidize the lipid moieties in LDL. It has been demonstrated that oxLDL and not native LDL is taken up by scavenger receptors on monocytes, smooth muscle cells and macrophages in the blood vessels. The oxidation of LDL increases the affinity of oxLDL to acetyl receptors of macrophages. As this pathway of oxLDL uptake is unregulated, it results in the formation of lipid-laden macrophages (foam cells).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins SPA527Hu01 Synthetic Oxidized Low Density Lipoprotein (OxLDL) Immunogen; Blocking Peptide.
Antibodies PAA527Hu08 Polyclonal Antibody to Oxidized Low Density Lipoprotein (OxLDL) IHC; ICC; IP
Assay Kits CEA527Hu ELISA Kit for Oxidized Low Density Lipoprotein (OxLDL) Enzyme-linked immunosorbent assay for Antigen Detection.
SEA527Hu ELISA Kit for Oxidized Low Density Lipoprotein (OxLDL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Oxidized Low Density Lipoprotein (OxLDL) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Oxidized Low Density Lipoprotein (OxLDL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Oxidized Low Density Lipoprotein (OxLDL) Polyclonal Antibody Customized Service Offer
Assay Kits SCA527Mu CLIA Kit for Oxidized Low Density Lipoprotein (OxLDL) Chemiluminescent immunoassay for Antigen Detection.
CEA527Mu ELISA Kit for Oxidized Low Density Lipoprotein (OxLDL) Enzyme-linked immunosorbent assay for Antigen Detection.
SEA527Mu ELISA Kit for Oxidized Low Density Lipoprotein (OxLDL) Enzyme-linked immunosorbent assay for Antigen Detection.
CCA527Mu CLIA Kit for Oxidized Low Density Lipoprotein (OxLDL) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Oxidized Low Density Lipoprotein (OxLDL) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Oxidized Low Density Lipoprotein (OxLDL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Oxidized Low Density Lipoprotein (OxLDL) Polyclonal Antibody Customized Service Offer
Assay Kits SEA527Ra ELISA Kit for Oxidized Low Density Lipoprotein (OxLDL) Enzyme-linked immunosorbent assay for Antigen Detection.
CEA527Ra ELISA Kit for Oxidized Low Density Lipoprotein (OxLDL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Oxidized Low Density Lipoprotein (OxLDL) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Oxidized Low Density Lipoprotein (OxLDL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Oxidized Low Density Lipoprotein (OxLDL) Polyclonal Antibody Customized Service Offer
Assay Kits SEA527Rb ELISA Kit for Oxidized Low Density Lipoprotein (OxLDL) Enzyme-linked immunosorbent assay for Antigen Detection.
CEA527Rb ELISA Kit for Oxidized Low Density Lipoprotein (OxLDL) Enzyme-linked immunosorbent assay for Antigen Detection.