Vascular Cell Adhesion Molecule 1 (VCAM1)

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CD106; INCAM-100; L1CAM

Vascular Cell Adhesion Molecule 1 (VCAM1)

VCAM-1 (CD106), a member of the immunoglobulin superfamily, is a cell surface protein expressed by activated endothelial cells and certain leukocytes (such as macrophages). VCAM-1 expression is induced by IL-1β, IL-4, TNF-α and IFN-γ. VCAM-1 binds to leukocyte integrins VLA-4 and α4β7. The rat and mouse SVCAM-1 proteins share approximately 76% amino acid similarity.

VCAM-1 is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA547Hu01 Recombinant Vascular Cell Adhesion Molecule 1 (VCAM1) Positive Control; Immunogen; SDS-PAGE; WB.
EPA547Hu61 Eukaryotic Vascular Cell Adhesion Molecule 1 (VCAM1) Positive Control; Immunogen; SDS-PAGE; WB.
APA547Hu61 Active Vascular Cell Adhesion Molecule 1 (VCAM1) Cell culture; Activity Assays.
Antibodies PAA547Hu01 Polyclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
MAA547Hu22 Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
LAA547Hu71 Biotin-Linked Polyclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC.
LAA547Hu81 FITC-Linked Polyclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IF.
MAA547Hu21 Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
PAA547Hu06 Polyclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
Assay Kits SEA547Hu ELISA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA547Hu CLIA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA547Mu01 Recombinant Vascular Cell Adhesion Molecule 1 (VCAM1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA547Mu02 Recombinant Vascular Cell Adhesion Molecule 1 (VCAM1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA547Mu03 Recombinant Vascular Cell Adhesion Molecule 1 (VCAM1) Positive Control; Immunogen; SDS-PAGE; WB.
EPA547Mu61 Eukaryotic Vascular Cell Adhesion Molecule 1 (VCAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA547Mu01 Polyclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
PAA547Mu02 Polyclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
LAA547Mu71 Biotin-Linked Polyclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC.
LAA547Mu81 FITC-Linked Polyclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IF.
MAA547Mu23 Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
PAA547Mu03 Polyclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
MAA547Mu21 Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
MAA547Mu22 Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
MAA547Mu24 Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
MAA547Mu25 Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
MAA547Mu27 Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
MAA547Mu29 Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
Assay Kits SEA547Mu ELISA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA547Mu CLIA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA547Ra01 Recombinant Vascular Cell Adhesion Molecule 1 (VCAM1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA547Ra02 Recombinant Vascular Cell Adhesion Molecule 1 (VCAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA547Ra01 Polyclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
MAA547Ra21 Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
PAA547Ra02 Polyclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
MAA547Ra22 Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
MAA547Ra23 Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
MAA547Ra24 Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
MAA547Ra25 Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
Assay Kits SEA547Ra ELISA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA547Rb01 Recombinant Vascular Cell Adhesion Molecule 1 (VCAM1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA547Rb02 Recombinant Vascular Cell Adhesion Molecule 1 (VCAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA547Rb52 Polyclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
PAA547Rb51 Polyclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB
MAA547Rb21 Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
LAA547Rb72 Biotin-Linked Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC.
LAA547Rb71 Biotin-Linked Polyclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC.
Assay Kits SEA547Rb ELISA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA547Si01 Recombinant Vascular Cell Adhesion Molecule 1 (VCAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA547Si01 Polyclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
MAA547Si21 Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
Assay Kits SEA547Si ELISA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA547Ca01 Recombinant Vascular Cell Adhesion Molecule 1 (VCAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA547Ca01 Polyclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
Assay Kits SEA547Ca ELISA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA547Po01 Recombinant Vascular Cell Adhesion Molecule 1 (VCAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA547Po01 Polyclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
MAA547Po21 Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1) WB; IHC; ICC; IP.
Assay Kits SEA547Po ELISA Kit for Vascular Cell Adhesion Molecule 1 (VCAM1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes."Cell 59:1203-1211(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Full length vascular cell adhesion molecule 1 (VCAM-1)."Nucleic Acids Res. 18:5901-5901(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning of an alternate form of vascular cell adhesion molecule-1 (VCAM1)."J. Biol. Chem. 266:6682-6685(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM1 gene."Proc. Natl. Acad. Sci. U.S.A. 88:7859-7863(1991) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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  8. "Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1)."J. Biol. Chem. 267:16323-16329(1992) [PubMed] [Europe PMC] [Abstract]
  9. "Alternative splicing of human VCAM-1 in activated vascular endothelium."Am. J. Pathol. 138:815-820(1991) [PubMed] [Europe PMC] [Abstract]
  10. "Activated endothelium binds lymphocytes through a novel binding site in the alternately spliced domain of vascular cell adhesion molecule-1."J. Exp. Med. 176:99-107(1992) [PubMed] [Europe PMC] [Abstract]
  11. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8-A resolution."Nature 373:539-544(1995) [PubMed] [Europe PMC] [Abstract]
  14. "The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4 integrin interaction."Proc. Natl. Acad. Sci. U.S.A. 92:5714-5718(1995) [PubMed] [Europe PMC] [Abstract]
  15. "Structure of a functional fragment of VCAM-1 refined at 1.9-A resolution."Acta Crystallogr. D 52:369-379(1996) [PubMed] [Europe PMC] [Abstract]