Phospholipase A2 Activating Protein (PLAP)

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PLAA; PLA2P; PLA2-P; DOA1

Phospholipase A2 Activating Protein (PLAP)

Phospholipase A2-activating protein (PLAP) is potentially important in regulating the inflammatory response through its activation of phospholipase A2, which catalyzes the release of arachidonic acid. By screening a human monocyte cDNA library with a mouse Plap cDNA, Chopra et al. (1999) isolated human PLAP cDNAs. The 738-amino acid human PLAP protein predicted by the cDNA sequence has a molecular mass of 80,826 kD; however, immunoblot analysis using antibodies against PLAP detected a 72- to 74-kD protein in human monocyte cell lysates. In mouse macrophages, an antisense Plap oligonucleotide blocked cholera toxin-induced arachidonic acid release, indicating a role for PLAP in the regulation of phospholipase A2 activation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA576Hu01 Recombinant Phospholipase A2 Activating Protein (PLAP) Positive Control; Immunogen; SDS-PAGE; WB.
RPA576Hu02 Recombinant Phospholipase A2 Activating Protein (PLAP) Positive Control; Immunogen; SDS-PAGE; WB.
RPA576Hu03 Recombinant Phospholipase A2 Activating Protein (PLAP) Positive Control; Immunogen; SDS-PAGE; WB.
RPA576Hu04 Recombinant Phospholipase A2 Activating Protein (PLAP) Positive Control; Immunogen; SDS-PAGE; WB.
RPA576Hu05 Recombinant Phospholipase A2 Activating Protein (PLAP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA576Hu01 Polyclonal Antibody to Phospholipase A2 Activating Protein (PLAP) WB,IHC,ICC/IF
MAA576Hu22 Monoclonal Antibody to Phospholipase A2 Activating Protein (PLAP) WB; IHC; ICC; IP.
PAA576Hu02 Polyclonal Antibody to Phospholipase A2 Activating Protein (PLAP) WB; ICC; IHC-P; IHC-F; ELISA.
PAA576Hu04 Polyclonal Antibody to Phospholipase A2 Activating Protein (PLAP) WB; IHC
PAA576Hu03 Polyclonal Antibody to Phospholipase A2 Activating Protein (PLAP) WB; IHC; ICC; IP.
LAA576Hu71 Biotin-Linked Polyclonal Antibody to Phospholipase A2 Activating Protein (PLAP) WB; IHC; ICC.
LAA576Hu81 FITC-Linked Polyclonal Antibody to Phospholipase A2 Activating Protein (PLAP) WB; IHC; ICC; IF.
PAA576Hu05 Polyclonal Antibody to Phospholipase A2 Activating Protein (PLAP) WB; IHC; ICC; IP.
Assay Kits SEA576Hu ELISA Kit for Phospholipase A2 Activating Protein (PLAP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phospholipase A2 Activating Protein (PLAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phospholipase A2 Activating Protein (PLAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phospholipase A2 Activating Protein (PLAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phospholipase A2 Activating Protein (PLAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phospholipase A2 Activating Protein (PLAP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phospholipase A2 Activating Protein (PLAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phospholipase A2 Activating Protein (PLAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phospholipase A2 Activating Protein (PLAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phospholipase A2 Activating Protein (PLAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phospholipase A2 Activating Protein (PLAP) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Chromosomal localization of phospholipase A2 activating protein, an ets2 target gene, to 9p21."Genomics 62:529-532(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Cloning of the human phospholipase A2 activating protein (hPLAP) gene on the chromosome 9p21 melanoma deleted region."Gene 239:155-161(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular characterization of cDNA for phospholipase A2-activating protein."Biochim. Biophys. Acta 1444:125-130(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Structural basis for ubiquitin recognition by a novel domain from human phospholipase A2-activating protein."J. Biol. Chem. 284:19043-19052(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Structure and function of the PLAA/Ufd3-p97/Cdc48 complex."J. Biol. Chem. 285:365-372(2010) [PubMed] [Europe PMC] [Abstract]