Proliferating Cell Nuclear Antigen (PCNA)

Proliferating Cell Nuclear Antigen a protein that acts as a processivity factor for DNA polymerase delta in eukaryotic cells. It achieves this processivity by encircling the DNA, thus creating a topological link to the genome. It is an example of a DNA clamp. The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA591Mi01 Recombinant Proliferating Cell Nuclear Antigen (PCNA) Positive Control; Immunogen; SDS-PAGE; WB.
RPA591Hu01 Recombinant Proliferating Cell Nuclear Antigen (PCNA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA591Mi01 Polyclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
CAA591Hu22 Anti-Proliferating Cell Nuclear Antigen (PCNA) Monoclonal Antibody Loading Control of WB.
CAA591Hu01 Anti-Proliferating Cell Nuclear Antigen (PCNA) Polyclonal Antibody Loading Control of WB.
MAA591Hu21 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
PAA591Hu01 Polyclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Mi21 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
CAA591Mi22 Anti-Proliferating Cell Nuclear Antigen (PCNA) Monoclonal Antibody Loading Control of WB
MAA591Mi22 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Mi23 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Hu22 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Hu23 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Hu25 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Hu24 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
Assay Kits SEA591Mi ELISA Kit for Proliferating Cell Nuclear Antigen (PCNA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA591Mi01 Recombinant Proliferating Cell Nuclear Antigen (PCNA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA591Mi01 Polyclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Mi21 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
CAA591Mi22 Anti-Proliferating Cell Nuclear Antigen (PCNA) Monoclonal Antibody Loading Control of WB
MAA591Mi22 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Mi23 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
Assay Kits SEA591Mi ELISA Kit for Proliferating Cell Nuclear Antigen (PCNA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA591Mi01 Recombinant Proliferating Cell Nuclear Antigen (PCNA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA591Mi01 Polyclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Mi21 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
CAA591Mi22 Anti-Proliferating Cell Nuclear Antigen (PCNA) Monoclonal Antibody Loading Control of WB
MAA591Mi22 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Mi23 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
Assay Kits SEA591Mi ELISA Kit for Proliferating Cell Nuclear Antigen (PCNA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proliferating Cell Nuclear Antigen (PCNA) Recombinant Protein Customized Service Offer
Antibodies PAA591Mi01 Polyclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Mi22 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Proliferating Cell Nuclear Antigen (PCNA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proliferating Cell Nuclear Antigen (PCNA) ELISA Kit Customized Service Offer

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proliferating Cell Nuclear Antigen (PCNA) Recombinant Protein Customized Service Offer
Antibodies PAA591Mi01 Polyclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Proliferating Cell Nuclear Antigen (PCNA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proliferating Cell Nuclear Antigen (PCNA) ELISA Kit Customized Service Offer

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proliferating Cell Nuclear Antigen (PCNA) Recombinant Protein Customized Service Offer
Antibodies PAA591Mi01 Polyclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Mi21 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
CAA591Mi22 Anti-Proliferating Cell Nuclear Antigen (PCNA) Monoclonal Antibody Loading Control of WB
MAA591Mi22 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Proliferating Cell Nuclear Antigen (PCNA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proliferating Cell Nuclear Antigen (PCNA) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proliferating Cell Nuclear Antigen (PCNA) Recombinant Protein Customized Service Offer
Antibodies PAA591Mi01 Polyclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Mi21 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Mi22 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
MAA591Mi23 Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Proliferating Cell Nuclear Antigen (PCNA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proliferating Cell Nuclear Antigen (PCNA) ELISA Kit Customized Service Offer
  1. "Cloning and sequence of the human nuclear protein cyclin: homology with DNA-binding proteins."Proc. Natl. Acad. Sci. U.S.A. 84:1575-1579(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Structure of the human gene for the proliferating cell nuclear antigen."J. Biol. Chem. 264:7466-7472(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The cell-cycle regulated proliferating cell nuclear antigen is required for SV40 DNA replication in vitro."Nature 326:471-475(1987) [PubMed] [Europe PMC] [Abstract]