≡

Homing Associated Cell Adhesion Molecule (HCAM)

[Edit]

CDW44; CD44; CSPG8; ECMR-III; HCELL; IN; LHR; MC56; MDU2; MDU3; MIC4; MUTCH-I; Pgp1; Hematopoietic Cell E- And L-Selectin Ligand; Chondroitin Sulfate Proteoglycan 8

Homing Associated Cell Adhesion Molecule (HCAM)
CCC A670
HGNC 1681
MGI 88338
PubMed 12484499
RGD 2307
UniProt P16070
Wiki CD44

The CD44 protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. Splice variants of CD44 on colon cancer cells display the HCELL glycoform, which mediates binding to vascular E-selectin under hemodynamic flow conditions, a critical step in colon cancer metastasis. CD44 gene transcription is at least in part activated by beta-catenin and Wnt signalling.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA670Hu01 Recombinant Homing Associated Cell Adhesion Molecule (HCAM) Positive Control; Immunogen; SDS-PAGE; WB.
CPA670Hu21 OVA Conjugated Homing Associated Cell Adhesion Molecule (HCAM) Immunogen; SDS-PAGE; WB.
EPA670Hu61 Eukaryotic Homing Associated Cell Adhesion Molecule (HCAM) Positive Control; Immunogen; SDS-PAGE; WB.
APA670Hu61 Active Homing Associated Cell Adhesion Molecule (HCAM) Cell culture; Activity Assays.
EPA670Hu62 Eukaryotic Homing Associated Cell Adhesion Molecule (HCAM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA670Hu01 Polyclonal Antibody to Homing Associated Cell Adhesion Molecule (HCAM) WB; IHC; ICC; IP.
MAA670Hu21 Monoclonal Antibody to Homing Associated Cell Adhesion Molecule (HCAM) WB; IHC; ICC; IP.
PAA670Hu08 Polyclonal Antibody to Homing Associated Cell Adhesion Molecule (HCAM) WB; IHC; ICC; IP.
LAA670Hu61 Cy3-Linked Polyclonal Antibody to Homing Associated Cell Adhesion Molecule (HCAM) WB; IHC; ICC; IF.
MAA670Hu26 Monoclonal Antibody to Homing Associated Cell Adhesion Molecule (HCAM) WB; IHC; ICC; IP.
MAA670Hu22 Monoclonal Antibody to Homing Associated Cell Adhesion Molecule (HCAM) WB; IHC; ICC; IP.
MAA670Hu23 Monoclonal Antibody to Homing Associated Cell Adhesion Molecule (HCAM) WB; IHC; ICC; IP.
MAA670Hu24 Monoclonal Antibody to Homing Associated Cell Adhesion Molecule (HCAM) WB; IHC; ICC; IP.
MAA670Hu27 Monoclonal Antibody to Homing Associated Cell Adhesion Molecule (HCAM) WB; IHC; ICC; IP.
MAA670Hu29 Monoclonal Antibody to Homing Associated Cell Adhesion Molecule (HCAM) WB; IHC; ICC; IP.
MAA670Hu25 Monoclonal Antibody to Homing Associated Cell Adhesion Molecule (HCAM) WB; IHC; ICC; IP.
Assay Kits SEA670Hu ELISA Kit for Homing Associated Cell Adhesion Molecule (HCAM) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA670Mu01 Recombinant Homing Associated Cell Adhesion Molecule (HCAM) Positive Control; Immunogen; SDS-PAGE; WB.
RPA670Mu02 Recombinant Homing Associated Cell Adhesion Molecule (HCAM) Positive Control; Immunogen; SDS-PAGE; WB.
RPA670Mu03 Recombinant Homing Associated Cell Adhesion Molecule (HCAM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA670Mu01 Polyclonal Antibody to Homing Associated Cell Adhesion Molecule (HCAM) WB; IHC; ICC; IP.
PAA670Mu02 Polyclonal Antibody to Homing Associated Cell Adhesion Molecule (HCAM) WB; IHC; ICC; IP.
Assay Kits SEA670Mu ELISA Kit for Homing Associated Cell Adhesion Molecule (HCAM) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA670Ra01 Recombinant Homing Associated Cell Adhesion Molecule (HCAM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA670Ra01 Polyclonal Antibody to Homing Associated Cell Adhesion Molecule (HCAM) WB; IHC
MAA670Ra21 Monoclonal Antibody to Homing Associated Cell Adhesion Molecule (HCAM) WB; IHC; ICC; IP.
Assay Kits SEA670Ra ELISA Kit for Homing Associated Cell Adhesion Molecule (HCAM) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA670Rb01 Recombinant Homing Associated Cell Adhesion Molecule (HCAM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Homing Associated Cell Adhesion Molecule (HCAM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Homing Associated Cell Adhesion Molecule (HCAM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Homing Associated Cell Adhesion Molecule (HCAM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Homing Associated Cell Adhesion Molecule (HCAM) ELISA Kit Customized Service Offer
  1. "A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family."Cell 56:1057-1062(1989) [PubMed] [Europe PMC] [Abstract]
  2. "The multispecific cell adhesion molecule CD44 is represented in reticulocyte cDNA."Biochem. Biophys. Res. Commun. 178:1127-1134(1991) [PubMed] [Europe PMC] [Abstract]
  3. "The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells."EMBO J. 10:343-348(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular cloning of CD44R1 and CD44R2, two novel isoforms of the human CD44 lymphocyte 'homing' receptor expressed by hemopoietic cells."J. Exp. Med. 174:1-5(1991) [PubMed] [Europe PMC] [Abstract]
  5. "The core protein of epican, a heparan sulfate proteoglycan on keratinocytes, is an alternative form of CD44."J. Invest. Dermatol. 99:886-891(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons."Proc. Natl. Acad. Sci. U.S.A. 89:12160-12164(1992) [PubMed] [Europe PMC] [Abstract]
  7. "CD44: a multitude of isoforms with diverse functions."Curr. Top. Microbiol. Immunol. 184:47-63(1993) [PubMed] [Europe PMC] [Abstract]
  8. "Novel variants of CD44 arising from alternative splicing: changes in the CD44 alternative splicing pattern of MCF-7 breast carcinoma cells treated with hyaluronidase."Mol. Carcinog. 7:212-220(1993) [PubMed] [Europe PMC] [Abstract]
  9. "Identification and characterization of CD44RC, a novel alternatively spliced soluble CD44 isoform that can potentiate the hyaluronan binding activity of cell surface CD44."Neoplasia 1:446-452(1999) [PubMed] [Europe PMC] [Abstract]
  10. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Expression of CD44 is repressed in neuroblastoma cells."Mol. Cell. Biol. 11:5446-5453(1991) [PubMed] [Europe PMC] [Abstract]
  14. "A human lymphocyte homing receptor, the hermes antigen, is related to cartilage proteoglycan core and link proteins."Cell 56:1063-1072(1989) [PubMed] [Europe PMC] [Abstract]
  15. "Anti-(glioma surface antigen) monoclonal antibody G-22 recognizes overexpressed CD44 in glioma cells."Cancer Immunol. Immunother. 39:313-317(1994) [PubMed] [Europe PMC] [Abstract]
  16. "A monoclonal antibody that blocks poliovirus attachment recognizes the lymphocyte homing receptor CD44."J. Virol. 68:1301-1308(1994) [PubMed] [Europe PMC] [Abstract]
  17. "Human keratinocytes express a new CD44 core protein (CD44E) as a heparan-sulfate intrinsic membrane proteoglycan with additional exons."J. Cell Biol. 113:207-221(1991) [PubMed] [Europe PMC] [Abstract]
  18. "Non-invasive detection of malignancy by identification of unusual CD44 gene activity in exfoliated cancer cells."BMJ 308:619-624(1994) [PubMed] [Europe PMC] [Abstract]
  19. "CD44 splice variants confer metastatic behavior in rats: homologous sequences are expressed in human tumor cell lines."Cancer Res. 51:5292-5297(1991) [PubMed] [Europe PMC] [Abstract]
  20. "CD44: from adhesion molecules to signalling regulators."Nat. Rev. Mol. Cell Biol. 4:33-45(2003) [PubMed] [Europe PMC] [Abstract]
  21. "Hyaluronan-dependent cell migration can be blocked by a CD44 cytoplasmic domain peptide containing a phosphoserine at position 325."J. Cell Sci. 111:1595-1601(1998) [PubMed] [Europe PMC] [Abstract]
  22. "A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility."Nat. Cell Biol. 4:399-407(2002) [PubMed] [Europe PMC] [Abstract]
  23. "CD44s adhesive function spontaneous and PMA-inducible CD44 cleavage are regulated at post-translational level in cells of melanocytic lineage."Melanoma Res. 13:325-337(2003) [PubMed] [Europe PMC] [Abstract]
  24. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  25. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  26. "RNA-binding IMPs promote cell adhesion and invadopodia formation."EMBO J. 25:1456-1468(2006) [PubMed] [Europe PMC] [Abstract]
  27. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  28. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  29. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  30. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  31. "Unc119 protects from Shigella infection by inhibiting the Abl family kinases."PLoS ONE 4:E5211-E5211(2009) [PubMed] [Europe PMC] [Abstract]
  32. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  33. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  34. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  35. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  36. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  37. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  38. "Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44."Mol. Cell 13:483-496(2004) [PubMed] [Europe PMC] [Abstract]
  39. "Ligand-induced structural changes of the CD44 hyaluronan-binding domain revealed by NMR."J. Biol. Chem. 281:40089-40095(2006) [PubMed] [Europe PMC] [Abstract]
  40. "A blood group-related polymorphism of CD44 abolishes a hyaluronan-binding consensus sequence without preventing hyaluronan binding."J. Biol. Chem. 271:7147-7153(1996) [PubMed] [Europe PMC] [Abstract]