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Dopamine Receptor D2 (DRD2)

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DR-D2; D2DR; D2R

Dopamine Receptor D2 (DRD2)
CCC A673
HGNC 3023
MGI 94924
PubMed 12554675
RGD 2520
UniProt P14416
Wiki DRD2

D2 (DRD2). There is a short version of D2 (D2Sh) and a long version of D2 (D2Lh): The D2Sh are pre-synaptic situated, having modulatory functions (called autoreceptor, they regulate the neurotransmission by feed-back mechanisms, i.e., synthesis, storage and release of dopamine into the synaptic cleft).

The D2Lh may have the classic function of a post-synaptic receptor, i.e., keep going on the neurotransmission (excitatory or inhibitory) once blocked by a receptor antagonist or stimulated by the endogenous neurotransmitter itself or a synthetic full or partial agonist.D2-like activation is coupled to the G protein Gαi, which subsequently increases phosphodiesterase activity. Phosphodiesterases break down cAMP, producing an inhibitory effect in neurons.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA673Hu01 Recombinant Dopamine Receptor D2 (DRD2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA673Hu02 Recombinant Dopamine Receptor D2 (DRD2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA673Hu01 Polyclonal Antibody to Dopamine Receptor D2 (DRD2) WB; IHC; ICC; IP.
MAA673Hu22 Monoclonal Antibody to Dopamine Receptor D2 (DRD2) WB; IHC; ICC; IP.
Assay Kits SEA673Hu ELISA Kit for Dopamine Receptor D2 (DRD2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA673Mu01 Recombinant Dopamine Receptor D2 (DRD2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA673Mu01 Polyclonal Antibody to Dopamine Receptor D2 (DRD2) WB; IHC; ICC; IP.
Assay Kits SEA673Mu ELISA Kit for Dopamine Receptor D2 (DRD2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA673Ra01 Recombinant Dopamine Receptor D2 (DRD2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA673Ra02 Recombinant Dopamine Receptor D2 (DRD2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA673Ra03 Recombinant Dopamine Receptor D2 (DRD2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA673Ra04 Recombinant Dopamine Receptor D2 (DRD2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA673Ra05 Recombinant Dopamine Receptor D2 (DRD2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA673Ra01 Polyclonal Antibody to Dopamine Receptor D2 (DRD2) WB; IHC; ICC; IP.
MAA673Ra21 Monoclonal Antibody to Dopamine Receptor D2 (DRD2) WB; IHC; ICC; IP.
Assay Kits SEA673Ra ELISA Kit for Dopamine Receptor D2 (DRD2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA673Ca01 Recombinant Dopamine Receptor D2 (DRD2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA673Ca01 Polyclonal Antibody to Dopamine Receptor D2 (DRD2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Dopamine Receptor D2 (DRD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dopamine Receptor D2 (DRD2) ELISA Kit Customized Service Offer
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  13. "Role of a Galphai2 protein splice variant in the formation of an intracellular dopamine D2 receptor pool."J. Cell Sci. 120:2171-2178(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Dopamine D2 and D4 receptor heteromerization and its allosteric receptor-receptor interactions."Biochem. Biophys. Res. Commun. 404:928-934(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors."Neuropharmacology 61:770-777(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity."Proc. Natl. Acad. Sci. U.S.A. 104:2001-2006(2007) [PubMed] [Europe PMC] [Abstract]
  17. ErratumProc. Natl. Acad. Sci. U.S.A. 109:1808-1808(2012) [PubMed] [Europe PMC] [Abstract]
  18. "A structural polymorphism of human dopamine D2 receptor, D2(Ser311->Cys)."Biochem. Biophys. Res. Commun. 196:1369-1375(1993) [PubMed] [Europe PMC] [Abstract]
  19. "Association of a missense change in the D2 dopamine receptor with myoclonus dystonia."Proc. Natl. Acad. Sci. U.S.A. 96:5173-5176(1999) [PubMed] [Europe PMC] [Abstract]
  20. "Association of the -141C Del variant of the dopamine D2 receptor (DRD2) with positive family history and suicidality in German alcoholics."Am. J. Med. Genet. B Neuropsychiatr. Genet. 132:46-49(2005) [PubMed] [Europe PMC] [Abstract]
  21. "Evaluation of the role of the D2 dopamine receptor in myoclonus dystonia." Ann. Neurol. 47:369-373(2000) [PubMed] [Europe PMC] [Abstract]
  22. "A population-specific HTR2B stop codon predisposes to severe impulsivity."Nature 468:1061-1066(2010) [PubMed] [Europe PMC] [Abstract]