Prothrombin Fragment 1+2 (F1+2)

Prothrombin is a carbohydrate-protein compound in plasma essential to coagulation. In response to bleeding, a complex series of clotting-factor interactions leads to its conversion by thromboplastin to thrombin, which transforms fibrinogen in plasma into fibrin. Fibrin and platelets combine to form a clot. Prothrombin and prothrombin fragment F1+2 (F1+2) were demonstrated in the tumor stroma on cancer cells and on small blood vessels in areas of neoangiogenesis at the host-tumor interface. F1+2 is an indicator of local activation of blood coagulation in cancer tissue. Thrombin itself is impossible to quantitate and so the use of surrogate markers is necessary. The measurement of F1+2 would be an excellent marker of thrombin generation. This is helped by the fact that F1+2 is not generated in vivo by any other mechanism. Fragment 1+2 has a half life of about 1 hour and is cleared from the bloodstream by the liver.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA710Hu01 Recombinant Prothrombin Fragment 1+2 (F1+2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA710Hu01 Polyclonal Antibody to Prothrombin Fragment 1+2 (F1+2) WB; IHC; ICC; IP.
LAA710Hu71 Biotin-Linked Polyclonal Antibody to Prothrombin Fragment 1+2 (F1+2) WB; IHC; ICC.
MAA710Hu21 Monoclonal Antibody to Prothrombin Fragment 1+2 (F1+2) WB; IHC; ICC; IP.
LAA710Hu72 Biotin-Linked Monoclonal Antibody to Prothrombin Fragment 1+2 (F1+2) WB; IHC; ICC.
MAA710Hu22 Monoclonal Antibody to Prothrombin Fragment 1+2 (F1+2) WB; IHC; ICC; IP.
MAA710Hu23 Monoclonal Antibody to Prothrombin Fragment 1+2 (F1+2) WB; IHC; ICC/IF
MAA710Hu24 Monoclonal Antibody to Prothrombin Fragment 1+2 (F1+2) WB; IHC
MAA710Hu25 Monoclonal Antibody to Prothrombin Fragment 1+2 (F1+2) WB; IHC; ICC; IP.
MAA710Hu26 Monoclonal Antibody to Prothrombin Fragment 1+2 (F1+2) WB; IHC; ICC; IP.
Assay Kits SEA710Hu ELISA Kit for Prothrombin Fragment 1+2 (F1+2) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA710Hu CLIA Kit for Prothrombin Fragment 1+2 (F1+2) Chemiluminescent immunoassay for Antigen Detection.
HEA710Hu High Sensitive ELISA Kit for Prothrombin Fragment 1+2 (F1+2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA710Mu01 Recombinant Prothrombin Fragment 1+2 (F1+2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA710Mu01 Polyclonal Antibody to Prothrombin Fragment 1+2 (F1+2) WB; IHC; ICC; IP.
Assay Kits SEA710Mu ELISA Kit for Prothrombin Fragment 1+2 (F1+2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA710Ra01 Recombinant Prothrombin Fragment 1+2 (F1+2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA710Ra01 Polyclonal Antibody to Prothrombin Fragment 1+2 (F1+2) WB; IHC; ICC; IP.
LAA710Ra81 FITC-Linked Polyclonal Antibody to Prothrombin Fragment 1+2 (F1+2) WB; IHC; ICC; IF.
LAA710Ra71 Biotin-Linked Polyclonal Antibody to Prothrombin Fragment 1+2 (F1+2) WB; IHC; ICC.
Assay Kits SCA710Ra CLIA Kit for Prothrombin Fragment 1+2 (F1+2) Chemiluminescent immunoassay for Antigen Detection.
SEA710Ra ELISA Kit for Prothrombin Fragment 1+2 (F1+2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA710Po01 Recombinant Prothrombin Fragment 1+2 (F1+2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA710Po01 Polyclonal Antibody to Prothrombin Fragment 1+2 (F1+2) WB; IHC; ICC; IP.
Assay Kits SEA710Po ELISA Kit for Prothrombin Fragment 1+2 (F1+2) Enzyme-linked immunosorbent assay for Antigen Detection.