Bone Morphogenetic Protein Receptor 1B (BMPR1B)

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CDw293; CD293; BMPR1-B; ALK6

Bone Morphogenetic Protein Receptor 1B (BMPR1B)

In the chick embryo, it has been shown that BMPR1B is found in precartilaginous condensations.BMPR1B is the major transducer of signals in these condensations as demonstrated in experiments using constitutively active BMPR1B receptors. BMPR1B is a more effective trasducer of GDF5 than BMPR1A.Unlike BMPR1A null mice, which die at an early embryonic stage, BMPR1B null mice are viable.

The deduced protein contains an atypical N-terminal signal sequence, a small hydrophilic cysteine-rich ligand-binding domain, a transmembrane region, and an intracellular kinase domain. Mouse and human BMPR1B are highly conserved, and BMPR1B is most closely related to BMPR1A.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA730Hu01Recombinant Bone Morphogenetic Protein Receptor 1B (BMPR1B)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA730Hu01Polyclonal Antibody to Bone Morphogenetic Protein Receptor 1B (BMPR1B)WB, ICC, IHC-P, IHC-F, ELISA
MAA730Hu22Monoclonal Antibody to Bone Morphogenetic Protein Receptor 1B (BMPR1B)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA730HuELISA Kit for Bone Morphogenetic Protein Receptor 1B (BMPR1B)Enzyme-linked immunosorbent assay

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Bone Morphogenetic Protein Receptor 1B (BMPR1B)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Bone Morphogenetic Protein Receptor 1B (BMPR1B)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Bone Morphogenetic Protein Receptor 1B (BMPR1B)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Bone Morphogenetic Protein Receptor 1B (BMPR1B)CLIA Kit Customized Service Offer
n/aELISA Kit for Bone Morphogenetic Protein Receptor 1B (BMPR1B)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Bone Morphogenetic Protein Receptor 1B (BMPR1B)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Bone Morphogenetic Protein Receptor 1B (BMPR1B)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Bone Morphogenetic Protein Receptor 1B (BMPR1B)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Bone Morphogenetic Protein Receptor 1B (BMPR1B)CLIA Kit Customized Service Offer
n/aELISA Kit for Bone Morphogenetic Protein Receptor 1B (BMPR1B)ELISA Kit Customized Service Offer
  1. "Cloning of human bone morphogenetic protein type IB receptor (BMPR-IB) and its expression in prostate cancer in comparison with other BMPRs."Oncogene 14:1377-1382(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Chromosomal localization of three human genes encoding bone morphogenetic protein receptors."Mamm. Genome 10:299-302(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A GDF5 point mutation strikes twice--causing BDA1 and SYNS2."PLoS Genet. 9:E1003846-E1003846(2013) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2."Proc. Natl. Acad. Sci. U.S.A. 100:12277-12282(2003) [PubMed] [Europe PMC] [Abstract]
  8. "A homozygous BMPR1B mutation causes a new subtype of acromesomelic chondrodysplasia with genital anomalies."J. Med. Genet. 42:314-317(2005) [PubMed] [Europe PMC] [Abstract]
  9. "A novel R486Q mutation in BMPR1B resulting in either a brachydactyly type C/symphalangism-like phenotype or brachydactyly type A2."Eur. J. Hum. Genet. 14:1248-1254(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]