Prostatic Inhibin Peptide (PIP)

Prostate inhibin peptide (PIP) is a follicle-stimulating hormone (FSH) regulating peptide produced by the prostate. a 94 amino acid protein which is secreted by the prostate gland in an androgen-independent manner. Previously, it has been demonstrated that PIP appears to inhibit follicle-stimulating-hormone (FSH) secretion by the pituitary and prostate glands. In vitro, the Dunning R3327 rat prostate cancer cell line MAT-LyLu (MLL) cells and the human prostate cancer cell line PC-3, are stimulated to grow in response to exogenous FSH and these effects are blocked by PIP. In vivo, PIP inhibits the growth of the highly metastatic MLL prostate cancer cell line. A comparison of hormone levels in control and PIP-treated rats demonstrates a significant inhibition of FSH in treated animals. It appears that, in vivo, PIP may inhibit prostate cancer growth by inhibiting FSH. PIP may represent a novel hormonal treatment for prostate cancer.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Prostatic Inhibin Peptide (PIP) Antigenic Transformation Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prostatic Inhibin Peptide (PIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prostatic Inhibin Peptide (PIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prostatic Inhibin Peptide (PIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prostatic Inhibin Peptide (PIP) ELISA Kit Customized Service Offer