Hexokinase 1 (HK1)

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HK1-Ta; HK1-Tb; HK1-Tc; HKI; HXK1; Brain form hexokinase

Hexokinase 1 (HK1)

A hexokinase is an enzyme that phosphorylates hexoses (six-carbon sugars), forming hexose phosphate. In most organisms, glucose is the most important substrate of hexokinases, and glucose-6-phosphate the most important product. Hexokinase-1 a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA775Hu01 Recombinant Hexokinase 1 (HK1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA775Hu02 Recombinant Hexokinase 1 (HK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA775Hu01 Polyclonal Antibody to Hexokinase 1 (HK1) WB; ICC; IHC-P; IHC-F; ELISA.
MAA775Hu22 Monoclonal Antibody to Hexokinase 1 (HK1) WB; IHC; ICC; IP.
PAA775Hu02 Polyclonal Antibody to Hexokinase 1 (HK1) WB; IHC; ICC; IP.
LAA775Hu71 Biotin-Linked Polyclonal Antibody to Hexokinase 1 (HK1) WB; IHC; ICC.
Assay Kits SEA775Hu ELISA Kit for Hexokinase 1 (HK1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA775Mu01 Recombinant Hexokinase 1 (HK1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA775Mu02 Recombinant Hexokinase 1 (HK1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA775Mu03 Recombinant Hexokinase 1 (HK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA775Mu01 Polyclonal Antibody to Hexokinase 1 (HK1) WB; IHC; ICC; IP.
PAA775Mu02 Polyclonal Antibody to Hexokinase 1 (HK1) WB; IHC; ICC; IP.
PAA775Mu03 Polyclonal Antibody to Hexokinase 1 (HK1) WB; IHC; ICC; IP.
LAA775Mu71 Biotin-Linked Polyclonal Antibody to Hexokinase 1 (HK1) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Hexokinase 1 (HK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hexokinase 1 (HK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA775Ra01 Recombinant Hexokinase 1 (HK1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA775Ra02 Recombinant Hexokinase 1 (HK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA775Ra01 Polyclonal Antibody to Hexokinase 1 (HK1) WB; IHC; ICC; IP.
PAA775Ra02 Polyclonal Antibody to Hexokinase 1 (HK1) WB; IHC; ICC; IP.
LAA775Ra71 Biotin-Linked Polyclonal Antibody to Hexokinase 1 (HK1) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Hexokinase 1 (HK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hexokinase 1 (HK1) ELISA Kit Customized Service Offer
  1. "Human hexokinase: sequences of amino- and carboxyl-terminal halves are homologous."Biochem. Biophys. Res. Commun. 157:937-943(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Structure of the human hexokinase type I gene and nucleotide sequence of the 5' flanking region."Biochem. J. 331:607-613(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Structure of the 5' region of the human hexokinase type I (HKI) gene and identification of an additional testis-specific HKI mRNA."Biochim. Biophys. Acta 1493:19-26(2000) [PubMed] [Europe PMC] [Abstract]
  6. "The erythrocyte-specific hexokinase isozyme (HKR) and the common hexokinase isozyme (HKI) are produced from a single gene by alternate promoters."Blood 90:272-272(1998)