Hexokinase 1 (HK1)

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HK1-Ta; HK1-Tb; HK1-Tc; HKI; HXK1; Brain form hexokinase

Hexokinase 1 (HK1)

A hexokinase is an enzyme that phosphorylates hexoses (six-carbon sugars), forming hexose phosphate. In most organisms, glucose is the most important substrate of hexokinases, and glucose-6-phosphate the most important product. Hexokinase-1 a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA775Hu01Recombinant Hexokinase 1 (HK1)SDS-PAGE; WB; ELISA; IP.
RPA775Hu02Recombinant Hexokinase 1 (HK1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA775Hu01Polyclonal Antibody to Hexokinase 1 (HK1)WB, ICC, IHC-P, IHC-F, ELISA
MAA775Hu22Monoclonal Antibody to Hexokinase 1 (HK1)WB, ICC, IHC-P, IHC-F, ELISA
PAA775Hu02Polyclonal Antibody to Hexokinase 1 (HK1)WB, ICC, IHC-P, IHC-F, ELISA
LAA775Hu71Biotin-Linked Polyclonal Antibody to Hexokinase 1 (HK1)IHC;WB;ELISA
Assay KitsSEA775HuELISA Kit for Hexokinase 1 (HK1)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA775Mu01Recombinant Hexokinase 1 (HK1)SDS-PAGE; WB; ELISA; IP.
RPA775Mu02Recombinant Hexokinase 1 (HK1)SDS-PAGE; WB; ELISA; IP.
RPA775Mu03Recombinant Hexokinase 1 (HK1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA775Mu01Polyclonal Antibody to Hexokinase 1 (HK1)WB, ICC, IHC-P, IHC-F, ELISA
PAA775Mu02Polyclonal Antibody to Hexokinase 1 (HK1)WB, ICC, IHC-P, IHC-F, ELISA
PAA775Mu03Polyclonal Antibody to Hexokinase 1 (HK1)WB, ICC, IHC-P, IHC-F, ELISA
LAA775Mu71Biotin-Linked Polyclonal Antibody to Hexokinase 1 (HK1)IHC;WB;ELISA
Assay Kitsn/aCLIA Kit for Hexokinase 1 (HK1)CLIA Kit Customized Service Offer
n/aELISA Kit for Hexokinase 1 (HK1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA775Ra01Recombinant Hexokinase 1 (HK1)SDS-PAGE; WB; ELISA; IP.
RPA775Ra02Recombinant Hexokinase 1 (HK1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA775Ra01Polyclonal Antibody to Hexokinase 1 (HK1)WB, ICC, IHC-P, IHC-F, ELISA
PAA775Ra02Polyclonal Antibody to Hexokinase 1 (HK1)WB, ICC, IHC-P, IHC-F, ELISA
LAA775Ra71Biotin-Linked Polyclonal Antibody to Hexokinase 1 (HK1)IHC;WB;ELISA
Assay Kitsn/aCLIA Kit for Hexokinase 1 (HK1)CLIA Kit Customized Service Offer
n/aELISA Kit for Hexokinase 1 (HK1)ELISA Kit Customized Service Offer
  1. "Human hexokinase: sequences of amino- and carboxyl-terminal halves are homologous."Biochem. Biophys. Res. Commun. 157:937-943(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Structure of the human hexokinase type I gene and nucleotide sequence of the 5' flanking region."Biochem. J. 331:607-613(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Structure of the 5' region of the human hexokinase type I (HKI) gene and identification of an additional testis-specific HKI mRNA."Biochim. Biophys. Acta 1493:19-26(2000) [PubMed] [Europe PMC] [Abstract]
  6. "The erythrocyte-specific hexokinase isozyme (HKR) and the common hexokinase isozyme (HKI) are produced from a single gene by alternate promoters."Blood 90:272-272(1998)