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Inducible T-Cell Co Stimulator Ligand (ICOSLG)

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CD275; B7-H2; B7H2; B7RP-1; B7RP1; GL50; ICOS-L; ICOSL; LICOS; B7-like protein Gl50; B7-related protein 1

Inducible T-Cell Co Stimulator Ligand (ICOSLG)
CCC A787
HGNC 17087
MGI 1354701
PubMed 21958057
RGD 1562791
UniProt O75144
Wiki ICOSLG

ICOSLG has also been designated as CD275 (cluster of differentiation 275).BIAcore analysis by Yoshinaga et al. (2000) indicated that B7RP1 binds preferentially to ICOS and does not bind to CTLA4. Flow cytometric analysis demonstrated that tumor necrosis factor-alpha  enhances B7RP1 expression on B cells and monocytes, but decreases its expression on dendritic cells.

B7RP1 fusion protein or cells expressing B7RP1 enhanced T-cell proliferation and interleukin-2 (IL2; 147680)-dependent cytokine production (gamma-interferon and IL10 but not IL2) in response to anti-CD3 stimulation. This enhancement could be blocked by soluble ICOS.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA787Hu01 Recombinant Inducible T-Cell Co Stimulator Ligand (ICOSLG) Positive Control; Immunogen; SDS-PAGE; WB.
EPA787Hu61 Eukaryotic Inducible T-Cell Co Stimulator Ligand (ICOSLG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA787Hu01 Polyclonal Antibody to Inducible T-Cell Co Stimulator Ligand (ICOSLG) WB,IHC
MAA787Hu21 Monoclonal Antibody to Inducible T-Cell Co Stimulator Ligand (ICOSLG) WB; IHC; ICC; IP.
MAA787Hu22 Monoclonal Antibody to Inducible T-Cell Co Stimulator Ligand (ICOSLG) WB; IHC; ICC; IP.
Assay Kits SEA787Hu ELISA Kit for Inducible T-Cell Co Stimulator Ligand (ICOSLG) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA787Mu01 Recombinant Inducible T-Cell Co Stimulator Ligand (ICOSLG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA787Mu01 Polyclonal Antibody to Inducible T-Cell Co Stimulator Ligand (ICOSLG) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Inducible T-Cell Co Stimulator Ligand (ICOSLG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inducible T-Cell Co Stimulator Ligand (ICOSLG) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inducible T-Cell Co Stimulator Ligand (ICOSLG) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inducible T-Cell Co Stimulator Ligand (ICOSLG) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inducible T-Cell Co Stimulator Ligand (ICOSLG) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inducible T-Cell Co Stimulator Ligand (ICOSLG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inducible T-Cell Co Stimulator Ligand (ICOSLG) ELISA Kit Customized Service Offer
  1. "Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS."Blood 96:2808-2813(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS."Int. Immunol. 12:1439-1447(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor."J. Immunol. 164:1653-1657(2000) [PubMed] [Europe PMC] [Abstract]
  4. "GL50 molecules and uses therefor."Patent number WO0121796, 29-MAR-2001
  5. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Characterization of human inducible costimulator ligand expression and function."J. Immunol. 164:4689-4696(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]