Programmed Cell Death Protein 1 Ligand 1 (PDL1)

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CD274; PDCD1LG1; B7-H; B7H1; PD-L1; PDCD1L1; PDCD1-LG1; Programed Death Ligand 1

Programmed Cell Death Protein 1 Ligand 1 (PDL1)

CD274 (Cluster of Differentiation 274) also known as PD-L1 (Programed Death Ligand-1) or B7-H1 is a protein,PD-L1 binds to its receptor, PD-1, found on activated T cells, B cells, and myeloid cells, to modulate activation or inhibition. The affinity between PD-L1 and PD-1, as defined by the dissociation constant Kd, is 770nM. Interestingly, PD-L1 also has an appreciable affinity for the costimulatory molecule CD80 (B7-1), but not CD86 (B7-2).

CD80's affinity for PD-L1, 1.4µM, is intermediate between its affinities for CD28 and CTLA-4 (4.0µM and 400nM, respectively). The related molecule PD-L2 has no such affinity for CD80 or CD86, but shares PD-1 as a receptor (with a stronger Kd of 140nM).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA788Hu01 Recombinant Programmed Cell Death Protein 1 Ligand 1 (PDL1) Positive Control; Immunogen; SDS-PAGE; WB.
EPA788Hu61 Eukaryotic Programmed Cell Death Protein 1 Ligand 1 (PDL1) Positive Control; Immunogen; SDS-PAGE; WB.
APA788Hu61 Active Programmed Cell Death Protein 1 Ligand 1 (PDL1) Cell culture; Activity Assays.
Antibodies PAA788Hu01 Polyclonal Antibody to Programmed Cell Death Protein 1 Ligand 1 (PDL1) WB; IHC; ICC; IP.
MAA788Hu22 Monoclonal Antibody to Programmed Cell Death Protein 1 Ligand 1 (PDL1) WB; IHC; ICC; IP.
LAA788Hu72 Biotin-Linked Monoclonal Antibody to Programmed Cell Death Protein 1 Ligand 1 (PDL1) WB; IHC; ICC.
MAA788Hu21 Monoclonal Antibody to Programmed Cell Death Protein 1 Ligand 1 (PDL1) WB; IHC; ICC; IP.
Assay Kits SEA788Hu ELISA Kit for Programmed Cell Death Protein 1 Ligand 1 (PDL1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA788Hu CLIA Kit for Programmed Cell Death Protein 1 Ligand 1 (PDL1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA788Mu01 Recombinant Programmed Cell Death Protein 1 Ligand 1 (PDL1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA788Mu02 Recombinant Programmed Cell Death Protein 1 Ligand 1 (PDL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA788Mu01 Polyclonal Antibody to Programmed Cell Death Protein 1 Ligand 1 (PDL1) WB; IHC; ICC; IP.
PAA788Mu02 Polyclonal Antibody to Programmed Cell Death Protein 1 Ligand 1 (PDL1) WB; IHC; ICC; IP.
Assay Kits SEA788Mu ELISA Kit for Programmed Cell Death Protein 1 Ligand 1 (PDL1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA788Ra01 Recombinant Programmed Cell Death Protein 1 Ligand 1 (PDL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA788Ra01 Polyclonal Antibody to Programmed Cell Death Protein 1 Ligand 1 (PDL1) WB; IHC; ICC; IP.
MAA788Ra21 Monoclonal Antibody to Programmed Cell Death Protein 1 Ligand 1 (PDL1) WB; IHC; ICC; IP.
Assay Kits SEA788Ra ELISA Kit for Programmed Cell Death Protein 1 Ligand 1 (PDL1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion."Nat. Med. 5:1365-1369(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Engagement of the PD-1 immunoinhibitory receptor by a novel B7-family member leads to negative regulation of lymphocyte activation."J. Exp. Med. 192:1027-1034(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of a novel splice variant of human PD-L1 mRNA encoding an isoform-lacking Igv-like domain."Acta Pharmacol. Sin. 26:462-468(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  8. "The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors."Proc. Natl. Acad. Sci. U.S.A. 105:3011-3016(2008) [PubMed] [Europe PMC] [Abstract]