Programmed Cell Death Protein 1 Ligand 2 (PDL2)

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CD273; B7DC; Btdc; PD-L2; PDCD1-L2; PDCD1LG2

Programmed Cell Death Protein 1 Ligand 2 (PDL2)

Using flow cytometric analysis, Latchman et al. (2001) showed that the IgV region of mouse Pdl2, like Pdl1, binds to human PDCD1 but not to CTLA4, CD28 , or ICOS. Stimulation of mouse T cells with anti-CD3 and Pdl2 or Pdl1 resulted in inhibition of proliferation and cytokine production, and Pdl2 could inhibit T-cell receptor -CD28 signals at low antigen concentrations. Latchman et al. (2001) proposed that blocking of the PDL-PDCD1 pathway may enhance antitumor immunity, whereas stimulating this pathway may help downregulate graft rejection and autoimmune and allergic reactions.

Latchman et al. (2001) mapped the PDL2 gene to chromosome 9p24.2, in close proximity to the PDL1 gene. Tseng et al. (2001) mapped the mouse Pdl2 gene to chromosome 19C2-C3.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA789Hu01 Recombinant Programmed Cell Death Protein 1 Ligand 2 (PDL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA789Hu01 Polyclonal Antibody to Programmed Cell Death Protein 1 Ligand 2 (PDL2) WB; IHC; ICC; IP.
MAA789Hu21 Monoclonal Antibody to Programmed Cell Death Protein 1 Ligand 2 (PDL2) WB; IHC; ICC; IP.
Assay Kits SEA789Hu ELISA Kit for Programmed Cell Death Protein 1 Ligand 2 (PDL2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA789Mu01 Recombinant Programmed Cell Death Protein 1 Ligand 2 (PDL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA789Mu01 Polyclonal Antibody to Programmed Cell Death Protein 1 Ligand 2 (PDL2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Programmed Cell Death Protein 1 Ligand 2 (PDL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Programmed Cell Death Protein 1 Ligand 2 (PDL2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA789Ra01 Recombinant Programmed Cell Death Protein 1 Ligand 2 (PDL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA789Ra01 Polyclonal Antibody to Programmed Cell Death Protein 1 Ligand 2 (PDL2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Programmed Cell Death Protein 1 Ligand 2 (PDL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Programmed Cell Death Protein 1 Ligand 2 (PDL2) ELISA Kit Customized Service Offer
  1. "B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells."J. Exp. Med. 193:839-846(2001) [PubMed] [Europe PMC] [Abstract]
  2. "PD-L2 is a second ligand for PD-1 and inhibits T cell activation." Nat. Immunol. 2:261-268(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and identification of two novel splice variants of human PD-L2."Acta Biochim. Biophys. Sin. 36:284-289(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]