Parathyroid Hormone Related Protein (PTHrP)
[Edit]PTHLH; HHM; PTHR; PLP; Osteostatin; Parathyroid Hormone Like Hormone
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Parathyroid hormone-related protein (or PTHrP) is a protein occasionally secreted by cancer cells (breast cancer, certain types of lung cancer including squamous cell carcinoma). However, it also has normal functions.
PTHrP acts as an endocrine, autocrine/ paracrine, and intracrine hormone. PTHrP is related in function to the "normal" parathyroid hormone. When a tumor secretes PTHrP, this can lead to hypercalcemia. As this is sometimes the first sign of the malignancy, hypercalcemia caused by PTHrP is considered a paraneoplastic phenomenon. PTHrP shares the same N-terminal end as parathyroid hormone and therefore it can bind to the same receptor (the Type I PTH receptor). PTHrP aids in normal mammary gland development and lactation as well as placental transfer of calcium.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
Organism species: Rattus norvegicus (Rat)
Organism species: Canis familiaris; Canine (Dog)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA819Ca01 | Recombinant Parathyroid Hormone Related Protein (PTHrP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA819Ca01 | Polyclonal Antibody to Parathyroid Hormone Related Protein (PTHrP) | WB; IHC; ICC; IP. |
| LAA819Ca71 | Biotin-Linked Polyclonal Antibody to Parathyroid Hormone Related Protein (PTHrP) | WB; IHC; ICC. | |
| MAA819Ca21 | Monoclonal Antibody to Parathyroid Hormone Related Protein (PTHrP) | WB; IHC; ICC; IP. | |
| Assay Kits | n/a | CLIA Kit for Parathyroid Hormone Related Protein (PTHrP) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Parathyroid Hormone Related Protein (PTHrP) | ELISA Kit Customized Service Offer |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA819Bo01 | Recombinant Parathyroid Hormone Related Protein (PTHrP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA819Bo01 | Polyclonal Antibody to Parathyroid Hormone Related Protein (PTHrP) | WB; IHC; ICC; IP. |
| MAA819Bo21 | Monoclonal Antibody to Parathyroid Hormone Related Protein (PTHrP) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA819Bo | ELISA Kit for Parathyroid Hormone Related Protein (PTHrP) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Chicken (Gallus)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA819Ga01 | Recombinant Parathyroid Hormone Related Protein (PTHrP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA819Ga01 | Polyclonal Antibody to Parathyroid Hormone Related Protein (PTHrP) | WB; IHC; ICC; IP. |
| LAA819Ga71 | Biotin-Linked Polyclonal Antibody to Parathyroid Hormone Related Protein (PTHrP) | WB; IHC; ICC. | |
| MAA819Ga21 | Monoclonal Antibody to Parathyroid Hormone Related Protein (PTHrP) | WB; IHC; ICC; IP. | |
| Assay Kits | n/a | CLIA Kit for Parathyroid Hormone Related Protein (PTHrP) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Parathyroid Hormone Related Protein (PTHrP) | ELISA Kit Customized Service Offer |
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- "Deletion and point mutations of PTHLH cause brachydactyly type E."Am. J. Hum. Genet. 86:434-439(2010) [PubMed] [Europe PMC] [Abstract]