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Immunoglobulin G3 (IgG3)

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IGHG3; HDC; Heavy chain disease protein; Ig Gamma-3 Chain C Region; Immunoglobulin Heavy Constant Gamma 3; G3m Marker; Immunoglobulin Gm3

Immunoglobulin G3 (IgG3)
CCC A829
HGNC 5527
PubMed 12075266
UniProt P01860

Heavy chain disease (HCD) is a naturally occurring lymphoproliferative disease in which variant monoclonal Ig heavy (H) chain fragments are found in serum or urine. Alexander et al. (1982) showed that the gene for the gamma-3 chain had undergone extensive NH(2)-terminal deletion. Cases of HCD involving immunoglobulins of the alpha and mu classes have also been described. Huck et al. (1986) cited several studies as yielding the following information on intervals between the several constant region genes of the heavy chains on chromosome 14. Huck et al. (1986) sequenced the CG3 gene from a member of the Tunisian family known to be homozygous for the G3m(b) allotypes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NPA829Hu01 Native Immunoglobulin G3 (IgG3) Positive Control; Immunogen; SDS-PAGE; WB.
RPA829Hu01 Recombinant Immunoglobulin G3 (IgG3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA829Hu01 Polyclonal Antibody to Immunoglobulin G3 (IgG3) WB; IHC; ICC; IP.
MAA829Hu22 Monoclonal Antibody to Immunoglobulin G3 (IgG3) WB; IHC; ICC; IP.
LAA829Hu71 Biotin-Linked Polyclonal Antibody to Immunoglobulin G3 (IgG3) WB; IHC; ICC.
LAA829Hu81 FITC-Linked Polyclonal Antibody to Immunoglobulin G3 (IgG3) WB; IHC; ICC; IF.
LAA829Hu72 Biotin-Linked Monoclonal Antibody to Immunoglobulin G3 (IgG3) WB; IHC; ICC.
LAA829Hu82 FITC-Linked Monoclonal Antibody to Immunoglobulin G3 (IgG3) WB; IHC; ICC; IF.
Assay Kits SEA829Hu ELISA Kit for Immunoglobulin G3 (IgG3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins CPA829Mu21 OVA Conjugated Immunoglobulin G3 (IgG3) Immunogen; SDS-PAGE; WB.
CPA829Mu22 OVA Conjugated Immunoglobulin G3 (IgG3) Immunogen; SDS-PAGE; WB.
NPA829Mu01 Native Immunoglobulin G3 (IgG3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA829Mu08 Polyclonal Antibody to Immunoglobulin G3 (IgG3) WB; IHC; ICC; IP.
PAA829Mu01 Polyclonal Antibody to Immunoglobulin G3 (IgG3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Immunoglobulin G3 (IgG3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Immunoglobulin G3 (IgG3) ELISA Kit Customized Service Offer
  1. "Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C gamma genes."Nucleic Acids Res. 14:1779-1789(1986) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Primary structure of human gamma 3 immunoglobulin deletion mutant: gamma 3 heavy-chain disease protein Wis."Biochemistry 19:4304-4308(1980) [PubMed] [Europe PMC] [Abstract]
  4. "Primary structure of the 'hinge' region of human IgG3. Probable quadruplication of a 15-amino acid residue basic unit."J. Biol. Chem. 252:883-889(1977) [PubMed] [Europe PMC] [Abstract]
  5. "The amino acid sequence of 'heavy chain disease' protein ZUC. Structure of the Fc fragment of immunoglobulin G3."Biochem. Biophys. Res. Commun. 71:907-914(1976) [PubMed] [Europe PMC] [Abstract]
  6. "Gamma heavy chain disease in man: cDNA sequence supports partial gene deletion model."Proc. Natl. Acad. Sci. U.S.A. 79:3260-3264(1982) [PubMed] [Europe PMC] [Abstract]
  7. "Structure of human immunoglobulin gamma genes: implications for evolution of a gene family."Cell 29:671-679(1982) [PubMed] [Europe PMC] [Abstract]
  8. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]