Heat Shock Protein Beta 2 (HSPb2)

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HSP-B2; MKBP; HSP27; Heat Shock 27kDa Protein 2; DMPK-binding protein

Heat Shock Protein Beta 2 (HSPb2)

Heat shock protein beta-2 is a protein encoded by the HSPB2 gene.Alpha-B-crystallin (CRYAB) is a member of the alpha-crystallin/small heat-shock protein (HSP) family and under various neuropathologic conditions accumulates in reactive astrocytes and degenerating neurons. In the 5-prime flanking region of the CRYAB gene on 11q22-q23, where a constitutive DNaseI hypersensitive site is located, Iwaki et al. (1997) identified a gene transcribed in the opposite direction. Analysis of its mRNA structure by RT-PCR and 5-prime/3-prime RACE revealed that this gene is composed of 2 exons and encodes a new member of the alpha-crystallin/hsp family. They termed the gene HSPB2. Iwaki et al. (1997) also determined the complete genomic structure of the rat homolog of HSPB2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA871Hu01 Recombinant Heat Shock Protein Beta 2 (HSPb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA871Hu01 Polyclonal Antibody to Heat Shock Protein Beta 2 (HSPb2) WB; ICC; IHC-P; IHC-F; ELISA.
MAA871Hu22 Monoclonal Antibody to Heat Shock Protein Beta 2 (HSPb2) WB; IHC; ICC; IP.
Assay Kits SEA871Hu ELISA Kit for Heat Shock Protein Beta 2 (HSPb2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA871Mu01 Recombinant Heat Shock Protein Beta 2 (HSPb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA871Mu01 Polyclonal Antibody to Heat Shock Protein Beta 2 (HSPb2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Heat Shock Protein Beta 2 (HSPb2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Heat Shock Protein Beta 2 (HSPb2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA871Ra01 Recombinant Heat Shock Protein Beta 2 (HSPb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA871Ra01 Polyclonal Antibody to Heat Shock Protein Beta 2 (HSPb2) WB; IHC; ICC; IP.
MAA871Ra21 Monoclonal Antibody to Heat Shock Protein Beta 2 (HSPb2) WB; IHC; ICC; IP.
Assay Kits SEA871Ra ELISA Kit for Heat Shock Protein Beta 2 (HSPb2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Heat Shock Protein Beta 2 (HSPb2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Heat Shock Protein Beta 2 (HSPb2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Heat Shock Protein Beta 2 (HSPb2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Heat Shock Protein Beta 2 (HSPb2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Heat Shock Protein Beta 2 (HSPb2) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA871Ga01 Recombinant Heat Shock Protein Beta 2 (HSPb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA871Ga01 Polyclonal Antibody to Heat Shock Protein Beta 2 (HSPb2) WB; IHC; ICC; IP.
MAA871Ga21 Monoclonal Antibody to Heat Shock Protein Beta 2 (HSPb2) WB; IHC; ICC; IP.
Assay Kits SEA871Ga ELISA Kit for Heat Shock Protein Beta 2 (HSPb2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Identification and characterization of the gene encoding a new member of the alpha-crystallin/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner."Genomics 45:386-394(1997) [PubMed] [Europe PMC] [Abstract]
  2. "MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase."J. Cell Biol. 140:1113-1124(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Muscle autoantigens in thyroid associated ophthalmopathy: the limits of molecular genetics."J. Endocrinol. Invest. 16:533-540(1993) [PubMed] [Europe PMC] [Abstract]
  5. "HSPB7 is a SC35 speckle resident small heat shock protein."Biochim. Biophys. Acta 1793:1343-1353(2009) [PubMed] [Europe PMC] [Abstract]