Discoidin Domain Receptor Family, Member 1 (DDR1)

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CD167a; CAK; DDR; EDDR1; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE; Cell adhesion kinase; Epithelial discoidin domain receptor 1; Mammary carcinoma kinase 10

Discoidin Domain Receptor Family, Member 1 (DDR1)

DDR1 is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA977Hu01 Recombinant Discoidin Domain Receptor Family, Member 1 (DDR1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA977Hu02 Recombinant Discoidin Domain Receptor Family, Member 1 (DDR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA977Hu01 Polyclonal Antibody to Discoidin Domain Receptor Family, Member 1 (DDR1) WB; IHC; ICC; IP.
Assay Kits SEA977Hu ELISA Kit for Discoidin Domain Receptor Family, Member 1 (DDR1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA977Mu01 Recombinant Discoidin Domain Receptor Family, Member 1 (DDR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA977Mu01 Polyclonal Antibody to Discoidin Domain Receptor Family, Member 1 (DDR1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Discoidin Domain Receptor Family, Member 1 (DDR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Discoidin Domain Receptor Family, Member 1 (DDR1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Discoidin Domain Receptor Family, Member 1 (DDR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Discoidin Domain Receptor Family, Member 1 (DDR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Discoidin Domain Receptor Family, Member 1 (DDR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Discoidin Domain Receptor Family, Member 1 (DDR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Discoidin Domain Receptor Family, Member 1 (DDR1) ELISA Kit Customized Service Offer
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  24. "DDR1 regulates the stabilization of cell surface E-cadherin and E-cadherin-mediated cell aggregation."J. Cell. Physiol. 224:387-397(2010) [PubMed] [Europe PMC] [Abstract]
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