Cytochrome P450 2E1 (CYP2E1)

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CPE1; CYPIIE1; P450-J; P450C2E; 4-nitrophenol 2-hydroxylase; Cytochrome P450 Family 2 Subfamily E 1; Cytochrome P450,Subfamily IIE(Ethanol-Inducible)Polypeptide 1

Cytochrome P450 2E1 (CYP2E1)

Cytochrome P450 2E1, a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. While it is only involved in the oxidative metabolism of a small range of substrates, there are some important drug interactions mediated by CYP2E1. CYP2E1 - CYP2E1 Ligands. While it is involved only in the oxidative metabolism of a small range of substrates, there are many important drug interactions mediated by CYP2E1.Within one day of birth, the rat hepatic CYP2E1 gene is activated transcriptionally. CYP2E1 expression is easily inducible. It seems that there exist two stages of induction, a posttranslational mechanism for increased protein stability at low levels of ethanol, and an additional transciptional induction at high levels of ethanol.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA988Hu01Recombinant Cytochrome P450 2E1 (CYP2E1)SDS-PAGE; WB; ELISA; IP.
RPA988Hu02Recombinant Cytochrome P450 2E1 (CYP2E1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA988Hu01Polyclonal Antibody to Cytochrome P450 2E1 (CYP2E1)WB, ICC, IHC-P, IHC-F, ELISA
LAA988Hu71Biotin-Linked Polyclonal Antibody to Cytochrome P450 2E1 (CYP2E1)IHC;WB;ELISA
PAA988Hu02Polyclonal Antibody to Cytochrome P450 2E1 (CYP2E1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA988HuELISA Kit for Cytochrome P450 2E1 (CYP2E1)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA988Mu01Recombinant Cytochrome P450 2E1 (CYP2E1)SDS-PAGE; WB; ELISA; IP.
RPA988Mu02Recombinant Cytochrome P450 2E1 (CYP2E1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA988Mu01Polyclonal Antibody to Cytochrome P450 2E1 (CYP2E1)WB, ICC, IHC-P, IHC-F, ELISA
PAA988Mu02Polyclonal Antibody to Cytochrome P450 2E1 (CYP2E1)WB, ICC, IHC-P, IHC-F, ELISA
LAA988Mu71Biotin-Linked Polyclonal Antibody to Cytochrome P450 2E1 (CYP2E1)IHC;WB;ELISA
Assay KitsSEA988MuELISA Kit for Cytochrome P450 2E1 (CYP2E1)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA988Ra01Recombinant Cytochrome P450 2E1 (CYP2E1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA988Ra01Polyclonal Antibody to Cytochrome P450 2E1 (CYP2E1)WB, ICC, IHC-P, IHC-F, ELISA
LAA988Ra71Biotin-Linked Polyclonal Antibody to Cytochrome P450 2E1 (CYP2E1)IHC;WB;ELISA
MAA988Ra21Monoclonal Antibody to Cytochrome P450 2E1 (CYP2E1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA988RaELISA Kit for Cytochrome P450 2E1 (CYP2E1)Enzyme-linked immunosorbent assay for Antigen Detection
  1. "Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme."J. Biol. Chem. 261:16689-16697(1986) [PubMed] [Europe PMC] [Abstract]
  2. "Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression."Biochemistry 27:9006-9013(1988) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Purification and characterization of human liver cytochrome P-450-ALC."Biochem. Biophys. Res. Commun. 148:232-238(1987) [PubMed] [Europe PMC] [Abstract]
  6. "Human liver cytochrome P-450 related to a rat acetone-inducible, nitrosamine-metabolizing cytochrome P-450: identification and isolation."Pharmacology 39:137-144(1989) [PubMed] [Europe PMC] [Abstract]
  7. "Expression of modified human cytochrome P450 2E1 in Escherichia coli, purification, and spectral and catalytic properties."Arch. Biochem. Biophys. 312:59-66(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Both cytochromes P450 2E1 and 3A are involved in the O-hydroxylation of p-nitrophenol, a catalytic activity known to be specific for P450 2E1."Chem. Res. Toxicol. 10:1205-1212(1997) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Structures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substrates."J. Biol. Chem. 283:33698-33707(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Genetic polymorphism of human CYP2E1: characterization of two variant alleles."Mol. Pharmacol. 51:370-376(1997) [PubMed] [Europe PMC] [Abstract]
  12. "Detection and characterization of novel polymorphisms in the CYP2E1 gene."Pharmacogenetics 8:543-552(1998) [PubMed] [Europe PMC] [Abstract]
  13. "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."Pharmacogenomics 5:895-931(2004) [PubMed] [Europe PMC] [Abstract]