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Albumin (ALB)

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Serum albumin

Albumin (ALB)
CCC B028
HGNC 399
MGI 87991
PubMed 15915465
RGD 2085
UniProt P02768
Wiki Albumin

  • Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in stabilizing extracellular fluid volume. Mutations in the ALB gene on chromosome 4 result in various anomalous proteins.Albumin is a globular unglycosylated serum protein of molecular weight 65,000. The albumin variant first described by Fraser et al. in a Welsh family was characterized as a dimer by Jamieson and Ganguly. The amino acid sequence has been determined in fragments of serum albumin of man. By 1980, at least 2 dozen electrophoretic variants of serum albumin had been reported but only 2 of them had been characterized with respect to their primary structure: albumin A and albumin B.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NPB028Hu01 Native Albumin (ALB) Positive Control; Immunogen; SDS-PAGE; WB.
EPB028Hu51 Eukaryotic Albumin (ALB) Positive Control; Immunogen; SDS-PAGE; WB.
RPB028Hu01 Recombinant Albumin (ALB) Positive Control; Immunogen; SDS-PAGE; WB.
RPB028Hu51 Recombinant Albumin (ALB) Positive Control; Immunogen; SDS-PAGE; WB.
NPB028Hu02 Native Albumin (ALB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAB028Hu22 Monoclonal Antibody to Albumin (ALB) WB; IHC
LAB028Hu71 Biotin-Linked Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC.
LAB028Hu81 FITC-Linked Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC; IF.
PAB028Hu07 Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC; IP.
PAB028Hu05 Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC; IP.
PAB028Hu01 Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC; IP.
MAB028Hu21 Monoclonal Antibody to Albumin (ALB) WB; IHC; ICC; IP.
PAB028Hu51 Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC; IP.
Assay Kits AEB028Hu ELISA Kit for Anti-Albumin Antibody (Anti-ALB) Enzyme-linked immunosorbent assay for Antibody Detection.
CEB028Hu ELISA Kit for Albumin (ALB) Enzyme-linked immunosorbent assay for Antigen Detection.
ACB028Hu CLIA Kit for Anti-Albumin Antibody (Anti-ALB) Chemiluminescent immunoassay for Antibody Detection.
CCB028Hu CLIA Kit for Albumin (ALB) Chemiluminescent immunoassay for Antigen Detection.
HEB028Hu High Sensitive ELISA Kit for Albumin (ALB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NPB028Mu01 Native Albumin (ALB) Positive Control; Immunogen; SDS-PAGE; WB.
RPB028Mu01 Recombinant Albumin (ALB) Positive Control; Immunogen; SDS-PAGE; WB.
RPB028Mu02 Recombinant Albumin (ALB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB028Mu01 Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC; IP.
LAB028Mu71 Biotin-Linked Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC.
LAB028Mu91 HRP-Linked Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC.
PAB028Mu02 Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC; IP.
Assay Kits CEB028Mu ELISA Kit for Albumin (ALB) Enzyme-linked immunosorbent assay for Antigen Detection.
CCB028Mu CLIA Kit for Albumin (ALB) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NPB028Ra01 Native Albumin (ALB) Positive Control; Immunogen; SDS-PAGE; WB.
RPB028Ra01 Recombinant Albumin (ALB) Positive Control; Immunogen; SDS-PAGE; WB.
EPB028Ra61 Eukaryotic Albumin (ALB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB028Ra01 Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC; IP.
LAB028Ra71 Biotin-Linked Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC.
LAB028Ra81 FITC-Linked Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC; IF.
MAB028Ra21 Monoclonal Antibody to Albumin (ALB) WB; IHC; ICC; IP.
MAB028Ra22 Monoclonal Antibody to Albumin (ALB) WB; IHC; ICC; IP.
Assay Kits CEB028Ra ELISA Kit for Albumin (ALB) Enzyme-linked immunosorbent assay for Antigen Detection.
CCB028Ra CLIA Kit for Albumin (ALB) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Cavia (Guinea pig )

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NPB028Gu01 Native Albumin (ALB) Positive Control; Immunogen; SDS-PAGE; WB.
RPB028Gu01 Recombinant Albumin (ALB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB028Gu01 Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC; IP.
LAB028Gu71 Biotin-Linked Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC.
MAB028Gu21 Monoclonal Antibody to Albumin (ALB) WB; IHC; ICC; IP.
Assay Kits CEB028Gu ELISA Kit for Albumin (ALB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NPB028Rb01 Native Albumin (ALB) Positive Control; Immunogen; SDS-PAGE; WB.
RPB028Rb01 Recombinant Albumin (ALB) Positive Control; Immunogen; SDS-PAGE; WB.
RPB028Rb02 Recombinant Albumin (ALB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB028Rb52 Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC; IP.
PAB028Rb51 Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC; IP.
LAB028Rb71 Biotin-Linked Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC.
LAB028Rb81 FITC-Linked Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC; IF.
PAB028Rb01 Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC; IP.
Assay Kits CEB028Rb ELISA Kit for Albumin (ALB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NPB028Si01 Native Albumin (ALB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB028Si01 Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC; IP.
LAB028Si71 Biotin-Linked Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC.
Assay Kits SEB028Si ELISA Kit for Albumin (ALB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB028Ca01 Recombinant Albumin (ALB) Positive Control; Immunogen; SDS-PAGE; WB.
NPB028Ca01 Native Albumin (ALB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB028Ca01 Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC; IP.
MAB028Ca21 Monoclonal Antibody to Albumin (ALB) WB; IHC; ICC; IP.
PAB028Ca05 Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC; IP.
Assay Kits CEB028Ca ELISA Kit for Albumin (ALB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NPB028Po01 Native Albumin (ALB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB028Po01 Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC; IP.
LAB028Po71 Biotin-Linked Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC.
LAB028Po81 FITC-Linked Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Albumin (ALB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Albumin (ALB) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NPB028Bo01 Native Albumin (ALB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB028Bo01 Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC; IP.
LAB028Bo71 Biotin-Linked Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC.
Assay Kits CEB028Bo ELISA Kit for Albumin (ALB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NPB028Cp01 Native Albumin (ALB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB028Cp01 Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC; IP.
LAB028Cp71 Biotin-Linked Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC.
LAB028Cp81 FITC-Linked Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Albumin (ALB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Albumin (ALB) ELISA Kit Customized Service Offer

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NPB028Eq01 Native Albumin (ALB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB028Eq01 Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC; IP.
LAB028Eq71 Biotin-Linked Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Albumin (ALB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Albumin (ALB) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NPB028Ga01 Native Albumin (ALB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB028Ga01 Polyclonal Antibody to Albumin (ALB) WB; IHC; ICC; IP.
Assay Kits CEB028Ga ELISA Kit for Albumin (ALB) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The sequence of human serum albumin cDNA and its expression in E. coli."Nucleic Acids Res. 9:6103-6114(1981) [PubMed] [Europe PMC] [Abstract]
  2. "Nucleotide sequence and the encoded amino acids of human serum albumin mRNA."Proc. Natl. Acad. Sci. U.S.A. 79:71-75(1982) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular structure of the human albumin gene is revealed by nucleotide sequence within q11-22 of chromosome 4."J. Biol. Chem. 261:6747-6757(1986) [PubMed] [Europe PMC] [Abstract]
  4. "Induction of galactose regulated gene expression in yeast."Patent number EP0248637, 09-DEC-1987
  5. "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs."Genome Res. 11:1392-1403(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  10. "The human albumin gene. Characterization of the 5' and 3' flanking regions and the polymorphic gene transcripts."J. Biol. Chem. 261:3244-3251(1986) [PubMed] [Europe PMC] [Abstract]
  11. "Complete amino acid sequence of human serum albumin."FEBS Lett. 58:134-137(1975) [PubMed] [Europe PMC] [Abstract]
  12. (In) Bing D.H. (eds.);The chemistry and physiology of the human plasma proteins, pp.23-40, Pergamon Press, New York (1979)
  13. "The human myocardial two-dimensional gel protein database: update 1994."Electrophoresis 15:1459-1465(1994) [PubMed] [Europe PMC] [Abstract]
  14. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  15. , Submitted (DEC-2008) to UniProtKB
  16. "The amino acid sequence of kinetensin, a novel peptide isolated from pepsin-treated human plasma: homology with human serum albumin, neurotensin and angiotensin."Biochem. Biophys. Res. Commun. 136:983-988(1986) [PubMed] [Europe PMC] [Abstract]
  17. "Structure of a biologically active neurotensin-related peptide obtained from pepsin-treated albumin(s)."J. Biol. Chem. 262:5968-5973(1987) [PubMed] [Europe PMC] [Abstract]
  18. "Lysine residue 199 of human serum albumin is modified by acetylsalicylic acid."FEBS Lett. 66:173-175(1976) [PubMed] [Europe PMC] [Abstract]
  19. "Enzymatic digestion and mass spectrometry in the study of advanced glycation end products/peptides."J. Am. Soc. Mass Spectrom. 15:496-509(2004) [PubMed] [Europe PMC] [Abstract]
  20. "Disulfide bonds in human serum albumin."Collect. Czech. Chem. Commun. 42:564-579(1977)
  21. "Lysine residue 240 of human serum albumin is involved in high-affinity binding of bilirubin."Biochem. J. 171:453-459(1978) [PubMed] [Europe PMC] [Abstract]
  22. "The principal site of nonenzymatic glycosylation of human serum albumin in vivo."J. Biol. Chem. 258:6142-6146(1983) [PubMed] [Europe PMC] [Abstract]
  23. "Nonenzymatic glycosylation of human serum albumin alters its conformation and function."J. Biol. Chem. 259:3812-3817(1984) [PubMed] [Europe PMC] [Abstract]
  24. "Nonenzymatic glycosylation of albumin in vivo. Identification of multiple glycosylated sites."J. Biol. Chem. 261:13542-13545(1986) [PubMed] [Europe PMC] [Abstract]
  25. "A nucleotide insertion and frameshift cause analbuminemia in an Italian family."Proc. Natl. Acad. Sci. U.S.A. 91:2275-2279(1994) [PubMed] [Europe PMC] [Abstract]
  26. "Albumin as a zinc carrier: properties of its high-affinity zinc-binding site."Biochem. Soc. Trans. 36:1317-1321(2008) [PubMed] [Europe PMC] [Abstract]
  27. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  28. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  29. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  30. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  31. "Three-dimensional structure of human serum albumin."Science 244:1195-1198(1989) [PubMed] [Europe PMC] [Abstract]
  32. "Structure of human serum albumin."Science 249:302-303(1990) [PubMed] [Europe PMC] [Abstract]
  33. "Atomic structure and chemistry of human serum albumin."Nature 358:209-215(1992) [PubMed] [Europe PMC] [Abstract]
  34. ErratumNature 364:362-362(1993)
  35. "Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites."Nat. Struct. Biol. 5:827-835(1998) [PubMed] [Europe PMC] [Abstract]
  36. "Crystal structure of human serum albumin at 2.5-A resolution."Protein Eng. 12:439-446(1999) [PubMed] [Europe PMC] [Abstract]
  37. "Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures."J. Biol. Chem. 275:38731-38738(2000) [PubMed] [Europe PMC] [Abstract]
  38. "Crystal structures of human serum albumin complexed with monounsaturated and polyunsaturated fatty acids."J. Mol. Biol. 314:955-960(2001) [PubMed] [Europe PMC] [Abstract]
  39. "Albumin Canterbury (313 Lys-->Asn). A point mutation in the second domain of serum albumin."Biochim. Biophys. Acta 912:191-197(1987) [PubMed] [Europe PMC] [Abstract]
  40. "Amino acid substitutions in genetic variants of human serum albumin and in sequences inferred from molecular cloning."Proc. Natl. Acad. Sci. U.S.A. 84:4413-4417(1987) [PubMed] [Europe PMC] [Abstract]
  41. "Amino acid substitutions in inherited albumin variants from Amerindian and Japanese populations."Proc. Natl. Acad. Sci. U.S.A. 84:8001-8005(1987) [PubMed] [Europe PMC] [Abstract]
  42. "Identical structural changes in inherited albumin variants from different populations."Proc. Natl. Acad. Sci. U.S.A. 86:434-438(1989) [PubMed] [Europe PMC] [Abstract]
  43. "Point substitutions in Japanese alloalbumins."Proc. Natl. Acad. Sci. U.S.A. 86:6092-6096(1989) [PubMed] [Europe PMC] [Abstract]
  44. "Point substitutions in albumin genetic variants from Asia."Proc. Natl. Acad. Sci. U.S.A. 87:497-501(1990) [PubMed] [Europe PMC] [Abstract]
  45. "Albumin Redhill (-1 Arg, 320 Ala-->Thr): a glycoprotein variant of human serum albumin whose precursor has an aberrant signal peptidase cleavage site."Proc. Natl. Acad. Sci. U.S.A. 87:26-30(1990) [PubMed] [Europe PMC] [Abstract]
  46. "Mutations in genetic variants of human serum albumin found in Italy."Proc. Natl. Acad. Sci. U.S.A. 87:8721-8725(1990) [PubMed] [Europe PMC] [Abstract]
  47. "A donor splice mutation and a single-base deletion produce two carboxyl-terminal variants of human serum albumin."Proc. Natl. Acad. Sci. U.S.A. 88:5959-5963(1991) [PubMed] [Europe PMC] [Abstract]
  48. "Genetic variants of serum albumin in Americans and Japanese."Proc. Natl. Acad. Sci. U.S.A. 88:9853-9857(1991) [PubMed] [Europe PMC] [Abstract]
  49. "Structural characterization of a glycoprotein variant of human serum albumin: albumin Casebrook (494 Asp-->Asn)."Biochim. Biophys. Acta 1097:49-54(1991) [PubMed] [Europe PMC] [Abstract]
  50. "Two alloalbumins with identical electrophoretic mobility are produced by differently charged amino acid substitutions."Biochim. Biophys. Acta 1119:232-238(1992) [PubMed] [Europe PMC] [Abstract]
  51. "Alloalbuminemia in Sweden: structural study and phenotypic distribution of nine albumin variants."Proc. Natl. Acad. Sci. U.S.A. 89:8225-8229(1992) [PubMed] [Europe PMC] [Abstract]
  52. "The structural characterization and bilirubin-binding properties of albumin Herborn, a [Lys240-->Glu] albumin mutant."Eur. J. Biochem. 214:437-444(1993) [PubMed] [Europe PMC] [Abstract]
  53. "Albumin Hawkes Bay; a low level variant caused by loss of a sulphydryl group at position 177."Biochim. Biophys. Acta 1182:46-50(1993) [PubMed] [Europe PMC] [Abstract]
  54. "Protein and DNA sequence analysis of a 'private' genetic variant: albumin Ortonovo (Glu-505-->Lys)."Biochim. Biophys. Acta 1225:27-32(1993) [PubMed] [Europe PMC] [Abstract]
  55. "Genetic variants of human serum albumin in Italy: point mutants and a carboxyl-terminal variant."Proc. Natl. Acad. Sci. U.S.A. 91:6476-6480(1994) [PubMed] [Europe PMC] [Abstract]
  56. "An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families."Biochem. Biophys. Res. Commun. 202:781-787(1994) [PubMed] [Europe PMC] [Abstract]
  57. "Identification of a human serum albumin species associated with familial dysalbuminemic hyperthyroxinemia."J. Clin. Endocrinol. Metab. 80:461-467(1995) [PubMed] [Europe PMC] [Abstract]
  58. "A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred."J. Clin. Endocrinol. Metab. 82:3246-3250(1997) [PubMed] [Europe PMC] [Abstract]
  59. "Familial dysalbuminemic hypertriiodothyroninemia: a new, dominantly inherited albumin defect."J. Clin. Endocrinol. Metab. 83:1448-1454(1998) [PubMed] [Europe PMC] [Abstract]
  60. "Towards defining the urinary proteome using liquid chromatography-tandem mass spectrometry I. Profiling an unfractionated tryptic digest."Proteomics 1:93-107(2001) [PubMed] [Europe PMC] [Abstract]
  61. "A nucleotide insertion and frameshift cause albumin Kenitra, an extended and O-glycosylated mutant of human serum albumin with two additional disulfide bridges."Eur. J. Biochem. 268:344-352(2001) [PubMed] [Europe PMC] [Abstract]