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Protein Disulfide Isomerase (PDI)

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P4HB; ERBA2L; PDIA1; PO4DB; PROHB, DSI, GIT, PDI, PO4HB, P4Hbeta; Prolyl 4-Hydroxylase Subunit Beta; Procollagen-Proline 2-Oxoglutarate 4-Dioxygenase Beta Polypeptide

Protein Disulfide Isomerase (PDI)
CCC B061
HGNC 8548
MGI 97464
PubMed 19476414
RGD 3244
UniProt P07237
Wiki PDI
PROHB is the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB061Hu01 Recombinant Protein Disulfide Isomerase (PDI) Positive Control; Immunogen; SDS-PAGE; WB.
APB061Hu01 Active Protein Disulfide Isomerase (PDI) Cell culture; Activity Assays.
Antibodies PAB061Hu01 Polyclonal Antibody to Protein Disulfide Isomerase (PDI) WB
MAB061Hu22 Monoclonal Antibody to Protein Disulfide Isomerase (PDI) WB; IHC; ICC; IP.
Assay Kits SEB061Hu ELISA Kit for Protein Disulfide Isomerase (PDI) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB061Mu01 Recombinant Protein Disulfide Isomerase (PDI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB061Mu01 Polyclonal Antibody to Protein Disulfide Isomerase (PDI) WB; IHC; ICC; IP.
LAB061Mu81 FITC-Linked Polyclonal Antibody to Protein Disulfide Isomerase (PDI) WB; IHC; ICC; IF.
LAB061Mu71 Biotin-Linked Polyclonal Antibody to Protein Disulfide Isomerase (PDI) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Protein Disulfide Isomerase (PDI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Disulfide Isomerase (PDI) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB061Ra01 Recombinant Protein Disulfide Isomerase (PDI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB061Ra01 Polyclonal Antibody to Protein Disulfide Isomerase (PDI) WB; IHC; ICC; IP.
LAB061Ra81 FITC-Linked Polyclonal Antibody to Protein Disulfide Isomerase (PDI) WB; IHC; ICC; IF.
LAB061Ra71 Biotin-Linked Polyclonal Antibody to Protein Disulfide Isomerase (PDI) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Protein Disulfide Isomerase (PDI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Disulfide Isomerase (PDI) ELISA Kit Customized Service Offer
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  9. , Submitted (FEB-1996) to UniProtKB
  10. "Development of a database of amino acid sequences for human colon carcinoma proteins separated by two-dimensional polyacrylamide gel electrophoresis."Electrophoresis 11:883-891(1990) [PubMed] [Europe PMC] [Abstract]
  11. "Human liver protein map: a reference database established by microsequencing and gel comparison."Electrophoresis 13:992-1001(1992) [PubMed] [Europe PMC] [Abstract]
  12. "Functions of characteristic Cys-Gly-His-Cys (CGHC) and Gln-Glu-Asp-Leu (QEDL) motifs of microsomal ER-60 protease."J. Biochem. 122:834-842(1997) [PubMed] [Europe PMC] [Abstract]
  13. , Submitted (DEC-2008) to UniProtKB
  14. "Characterization of a cDNA for human glutathione-insulin transhydrogenase (protein-disulfide isomerase/oxidoreductase)."Biochim. Biophys. Acta 949:169-180(1988) [PubMed] [Europe PMC] [Abstract]
  15. "Two-dimensional gel electrophoresis, protein electroblotting and microsequencing: a direct link between proteins and genes."Electrophoresis 11:528-536(1990) [PubMed] [Europe PMC] [Abstract]
  16. "Protein-disulfide isomerase (PDI) in FRTL5 cells. pH-dependent thyroglobulin/PDI interactions determine a novel PDI function in the post-endoplasmic reticulum of thyrocytes."J. Biol. Chem. 275:1920-1929(2000) [PubMed] [Europe PMC] [Abstract]
  17. "The catalytic activity of protein disulfide isomerase is involved in human immunodeficiency virus envelope-mediated membrane fusion after CD4 cell binding."J. Infect. Dis. 183:744-752(2001) [PubMed] [Europe PMC] [Abstract]
  18. "Is protein disulfide isomerase a redox-dependent molecular chaperone?"EMBO J. 21:6763-6770(2002) [PubMed] [Europe PMC] [Abstract]
  19. "Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death."J. Biol. Chem. 277:35386-35392(2002) [PubMed] [Europe PMC] [Abstract]
  20. "Inhibitors of protein-disulfide isomerase prevent cleavage of disulfide bonds in receptor-bound glycoprotein 120 and prevent HIV-1 entry."J. Biol. Chem. 277:50579-50588(2002) [PubMed] [Europe PMC] [Abstract]
  21. "Protein-disulfide isomerase-mediated reduction of two disulfide bonds of HIV envelope glycoprotein 120 occurs post-CXCR4 binding and is required for fusion."J. Biol. Chem. 278:3131-3136(2003) [PubMed] [Europe PMC] [Abstract]
  22. "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins."J. Proteome Res. 2:69-79(2003) [PubMed] [Europe PMC] [Abstract]
  23. "Protein disulfide isomerase."Biochim. Biophys. Acta 1699:35-44(2004) [PubMed] [Europe PMC] [Abstract]
  24. "Thiol/disulfide exchange is a prerequisite for CXCR4-tropic HIV-1 envelope-mediated T-cell fusion during viral entry."Blood 103:1586-1594(2004) [PubMed] [Europe PMC] [Abstract]
  25. "Glycosaminoglycans and protein disulfide isomerase-mediated reduction of HIV Env."Mol. Pharmacol. 67:1111-1118(2005) [PubMed] [Europe PMC] [Abstract]
  26. "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
  27. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  28. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  29. "Nuclear magnetic resonance characterization of the N-terminal thioredoxin-like domain of protein disulfide isomerase."Protein Sci. 4:2587-2593(1995) [PubMed] [Europe PMC] [Abstract]
  30. "Structure determination of the N-terminal thioredoxin-like domain of protein disulfide isomerase using multidimensional heteronuclear 13C/15N NMR spectroscopy."Biochemistry 35:7684-7691(1996) [PubMed] [Europe PMC] [Abstract]
  31. "The structure in solution of the B domain of protein disulfide isomerase."J. Biomol. NMR 13:357-368(1999) [PubMed] [Europe PMC] [Abstract]
  32. "The solution structure of the second thioredoxin-like domain of human protein disulfide-isomerase."Submitted (NOV-2005) to the PDB data bank