S100 Calcium Binding Protein A12 (S100A12)

[Edit]

CGRP; P6; CAAF1; CAGC; ENRAGE; MRP6; Calgranulin C; Calcium-binding protein in amniotic fluid 1; Extracellular newly identified RAGE-binding; Migration inhibitory factor-related 6

S100 Calcium Binding Protein A12 (S100A12)

S100A12 belongs to the S-100 (soluble in 100% saturated ammonium sulfate) family. Similar to other S100 proteins, S100A12 is small, it only has 91 amino acids, contains 2 EF-hand calcium-binding motifs and a Hinge domain. The hinge domain contributes significantly to its chemotactic properties. In the absence of divalent cations, S100A12 forms noncovalent homodimers; in the presence of calcium, zinc and copper ions, it forms tetramers or hexamers. S100A12 can interact with AGER and both calcium and zinc are essential for the interaction; it can Interact with CACYBP in a calcium-dependent manner. Besides, it can form heterodimers with S100A9. S100A12 plays a prominent role in the regulation of inflammatory processes and immune response. The concentration of S100A12 is high in the serum of patients suffering from various inflammatory disorders, including rheumatoid arthritis, psoriatic arthritis, Crohn's disease, ulcerative colitis, and Kawasaki disease.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB080Hu01 Recombinant S100 Calcium Binding Protein A12 (S100A12) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB080Hu01 Polyclonal Antibody to S100 Calcium Binding Protein A12 (S100A12) WB; IHC; ICC; IP.
MAB080Hu22 Monoclonal Antibody to S100 Calcium Binding Protein A12 (S100A12) WB; IHC; ICC; IP.
LAB080Hu71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein A12 (S100A12) WB; IHC; ICC.
LAB080Hu81 FITC-Linked Polyclonal Antibody to S100 Calcium Binding Protein A12 (S100A12) WB; IHC; ICC; IF.
MAB080Hu21 Monoclonal Antibody to S100 Calcium Binding Protein A12 (S100A12) WB
MAB080Hu23 Monoclonal Antibody to S100 Calcium Binding Protein A12 (S100A12) WB; IHC; ICC; IP.
MAB080Hu24 Monoclonal Antibody to S100 Calcium Binding Protein A12 (S100A12) WB.
MAB080Hu29 Monoclonal Antibody to S100 Calcium Binding Protein A12 (S100A12) WB; IHC; ICC; IP.
MAB080Hu27 Monoclonal Antibody to S100 Calcium Binding Protein A12 (S100A12) WB; IHC; ICC; IP.
MAB080Hu25 Monoclonal Antibody to S100 Calcium Binding Protein A12 (S100A12) WB,ICC/IF
Assay Kits SEB080Hu ELISA Kit for S100 Calcium Binding Protein A12 (S100A12) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB080Rb01 Recombinant S100 Calcium Binding Protein A12 (S100A12) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB080Rb51 Polyclonal Antibody to S100 Calcium Binding Protein A12 (S100A12) WB; IHC; ICC; IP.
PAB080Rb01 Polyclonal Antibody to S100 Calcium Binding Protein A12 (S100A12) WB; IHC; ICC; IP.
Assay Kits SEB080Rb ELISA Kit for S100 Calcium Binding Protein A12 (S100A12) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB080Po01 Recombinant S100 Calcium Binding Protein A12 (S100A12) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB080Po01 Polyclonal Antibody to S100 Calcium Binding Protein A12 (S100A12) WB; IHC; ICC; IP.
Assay Kits SEB080Po ELISA Kit for S100 Calcium Binding Protein A12 (S100A12) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB080Bo01 Recombinant S100 Calcium Binding Protein A12 (S100A12) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB080Bo01 Polyclonal Antibody to S100 Calcium Binding Protein A12 (S100A12) WB; IHC; ICC; IP.
Assay Kits SEB080Bo ELISA Kit for S100 Calcium Binding Protein A12 (S100A12) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human CAAF1 gene -- molecular cloning, gene structure, and chromosome mapping."Biochem. Biophys. Res. Commun. 221:356-360(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21."Cell Calcium 20:459-464(1996) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin."Biochem. Biophys. Res. Commun. 221:454-458(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Amino acid sequence determination of human S100A12 (P6, calgranulin C, CGRP, CAAF1) by tandem mass spectrometry."Biochem. Biophys. Res. Commun. 225:146-150(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Identification and characterization of a novel human neutrophil protein related to the S100 family."Biochem. J. 309:395-401(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Identification, isolation, and partial characterization of a 7.5-kDa surfactant-associated protein."Exp. Lung Res. 17:559-567(1991) [PubMed] [Europe PMC] [Abstract]
  9. "Calcitermin, a novel antimicrobial peptide isolated from human airway secretions."FEBS Lett. 504:5-10(2001) [PubMed] [Europe PMC] [Abstract]
  10. "CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family."J. Biol. Chem. 277:28848-28852(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Multiple structural states of S100A12: A key to its functional diversity."Microsc. Res. Tech. 60:581-592(2003) [PubMed] [Europe PMC] [Abstract]
  12. "S100A12 provokes mast cell activation: a potential amplification pathway in asthma and innate immunity."J. Allergy Clin. Immunol. 119:106-114(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Mast cell and monocyte recruitment by S100A12 and its hinge domain."J. Biol. Chem. 283:13035-13043(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Human S100A12: a novel key player in inflammation?"Amino Acids 36:381-389(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Anti-infective protective properties of S100 calgranulins."Antiinflamm. Antiallergy Agents Med. Chem. 8:290-305(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function."BMC Biochem. 10:11-11(2009) [PubMed] [Europe PMC] [Abstract]
  17. "S100 Calgranulins in inflammatory arthritis."Immunol. Cell Biol. 88:41-49(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Inflammation-associated S100 proteins: new mechanisms that regulate function."Amino Acids 41:821-842(2011) [PubMed] [Europe PMC] [Abstract]
  19. "The role of S100A12 as a systemic marker of inflammation."Int. J. Inflamm. 2012:907078-907078(2012) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "The three-dimensional structure of human S100A12."Acta Crystallogr. D 57:20-29(2001) [PubMed] [Europe PMC] [Abstract]
  22. "Structure of the human S100A12-copper complex: implications for host-parasite defence."Acta Crystallogr. D 59:859-867(2003) [PubMed] [Europe PMC] [Abstract]
  23. "The crystal structures of human S100A12 in apo form and in complex with zinc: new insights into S100A12 oligomerisation."J. Mol. Biol. 391:536-551(2009) [PubMed] [Europe PMC] [Abstract]