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Target Of The Antiproliferative Antibody 1 (TAPA1)

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CD81; S5.7; TAPA1; TSPAN28; Tetraspanin 28; Target Of Antiproliferative Antibody 1; 26 kDa cell surface protein TAPA-1

Target Of The Antiproliferative Antibody 1 (TAPA1)
CCC B160
HGNC 1701
MGI 1096398
PubMed 9597125
RGD 2315
UniProt P60033
Wiki CD81

CD81 molecule is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.

This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB160Hu01 Recombinant Target Of The Antiproliferative Antibody 1 (TAPA1) Positive Control; Immunogen; SDS-PAGE; WB.
EPB160Hu61 Eukaryotic Target Of The Antiproliferative Antibody 1 (TAPA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB160Hu01 Polyclonal Antibody to Target Of The Antiproliferative Antibody 1 (TAPA1) WB; IHC; ICC; IP.
MAB160Hu22 Monoclonal Antibody to Target Of The Antiproliferative Antibody 1 (TAPA1) WB; IHC; ICC; IP.
MAB160Hu21 Monoclonal Antibody to Target Of The Antiproliferative Antibody 1 (TAPA1) WB; IHC; ICC; IP.
MAB160Hu23 Monoclonal Antibody to Target Of The Antiproliferative Antibody 1 (TAPA1) WB; IHC; ICC; IP.
Assay Kits SEB160Hu ELISA Kit for Target Of The Antiproliferative Antibody 1 (TAPA1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Target Of The Antiproliferative Antibody 1 (TAPA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Target Of The Antiproliferative Antibody 1 (TAPA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Target Of The Antiproliferative Antibody 1 (TAPA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Target Of The Antiproliferative Antibody 1 (TAPA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Target Of The Antiproliferative Antibody 1 (TAPA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Target Of The Antiproliferative Antibody 1 (TAPA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Target Of The Antiproliferative Antibody 1 (TAPA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Target Of The Antiproliferative Antibody 1 (TAPA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Target Of The Antiproliferative Antibody 1 (TAPA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Target Of The Antiproliferative Antibody 1 (TAPA1) ELISA Kit Customized Service Offer
  1. "TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins."Mol. Cell. Biol. 10:4007-4015(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen."J. Immunol. 145:2207-2213(1990) [PubMed] [Europe PMC] [Abstract]
  5. "Structure and membrane topology of TAPA-1."J. Biol. Chem. 266:14597-14602(1991) [PubMed] [Europe PMC] [Abstract]
  6. "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily."J. Biol. Chem. 276:40545-40554(2001) [PubMed] [Europe PMC] [Abstract]
  7. "CD81-dependent binding of hepatitis C virus E1E2 heterodimers."J. Virol. 77:10677-10683(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor."J. Biol. Chem. 278:41624-41630(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association."Mol. Biol. Cell 15:2375-2387(2004) [PubMed] [Europe PMC] [Abstract]
  10. "CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency."J. Clin. Invest. 120:1265-1274(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling."Mol. Cell. Biol. 31:4550-4562(2011) [PubMed] [Europe PMC] [Abstract]
  13. "CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs."EMBO J. 20:12-18(2001) [PubMed] [Europe PMC] [Abstract]
  14. "Subunit association and conformational flexibility in the head subdomain of human CD81 large extracellular loop."Biol. Chem. 383:1447-1452(2002) [PubMed] [Europe PMC] [Abstract]