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Thioredoxin-interacting Protein (TXNIP)

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TBP2; HHCPA78; THIF; VDUP1;Thioredoxin Binding Protein 2 ; Vitamin D3-Upregulated Protein 1; Upregulated By 1,25-Dihydroxyvitamin D-3

Thioredoxin-interacting Protein (TXNIP)
CCC B162
HGNC 16952
MGI 1889549
PubMed 19759265
RGD 620886
UniProt Q9H3M7
Wiki TXNIP

Exposure to vitamin D3 (1,25-dihydroxyvitamin D3) or phorbol ester induces the bipotent HL-60 cell promyelocytic leukemia cell line to differentiate into monocytes/macrophages, whereas retinoic acid and dimethylsulfoxide induce differentiation towards granulocytes. The differentiation is accompanied by regulation of MYC , FOS , FMS (CSF1R), and myeloblastin (PRTN3;). By differential screening of HL60 cell lines, Chen and DeLuca (1994) identified a cDNA encoding TXNIP, which they termed VDUP1. The deduced TXNIP protein has 391 amino acids. Ribonuclease protection analysis showed dramatically increased expression of TXNIP in response to vitamin D3 but not to phorbol ester. Chen and DeLuca (1994) concluded that TXNIP is not involved in the differentiation process.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB162Hu01 Recombinant Thioredoxin-interacting Protein (TXNIP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB162Hu01 Polyclonal Antibody to Thioredoxin-interacting Protein (TXNIP) WB; IHC; ICC; IP.
MAB162Hu22 Monoclonal Antibody to Thioredoxin-interacting Protein (TXNIP) WB; IHC; ICC; IP.
Assay Kits SEB162Hu ELISA Kit for Thioredoxin-interacting Protein (TXNIP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB162Mu01 Recombinant Thioredoxin-interacting Protein (TXNIP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB162Mu02 Recombinant Thioredoxin-interacting Protein (TXNIP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB162Mu01 Polyclonal Antibody to Thioredoxin-interacting Protein (TXNIP) WB; IHC; ICC; IP.
PAB162Mu02 Polyclonal Antibody to Thioredoxin-interacting Protein (TXNIP) WB; IHC; ICC; IP.
Assay Kits SEB162Mu ELISA Kit for Thioredoxin-interacting Protein (TXNIP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thioredoxin-interacting Protein (TXNIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thioredoxin-interacting Protein (TXNIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thioredoxin-interacting Protein (TXNIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thioredoxin-interacting Protein (TXNIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thioredoxin-interacting Protein (TXNIP) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3."Biochim. Biophys. Acta 1219:26-32(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Regulation of the bioavailability of thioredoxin in the lens by a specific thioredoxin-binding protein (TBP-2)."Exp. Eye Res. 85:270-279(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression."Oncogene 22:4035-4046(2003) [PubMed] [Europe PMC] [Abstract]
  7. "hnRNP G elicits tumor-suppressive activity in part by upregulating the expression of Txnip."Biochem. Biophys. Res. Commun. 372:880-885(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation."J. Biol. Chem. 285:8869-8879(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1."Oncogene 30:3792-3801(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Structure of the N-terminal domain of human thioredoxin-interacting protein."Acta Crystallogr. D 69:333-344(2013) [PubMed] [Europe PMC] [Abstract]