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Chromogranin A (CHGA)

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CGA; SP-I; Parathyroid Secretory Protein 1; Vasostatin; Pancreastatin; Parastatin; Pituitary secretory protein I

Chromogranin A (CHGA)
CCC B212
HGNC 1929
MGI 88394
PubMed 7768066
RGD 2338
UniProt P10645
Wiki Chromogranin_A

Chromogranin A (CgA) is a glycoprotein found in neuroendocrine cells and may be useful as a tumor marker for neuroendocrine tumors. Elevated circulating chromogranin A (CgA) levels are found in neuroendocrine tumors (NETs), but the diagnostic usefulness of this marker is still debatable. Research demonstrates that higher CgA levels associate with metastatic disease, confirming that CgA levels can provide a helpful practical biochemical marker for the clinical management of NETs, but with low sensitivity and specificity.

Human chromogranin A is 439 amino acid protein with a molecular weight of 49 kilodalton. It is a secretory protein that is produced by the dense-core vesicles of neuroendocrine cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB212Hu01 Recombinant Chromogranin A (CHGA) Positive Control; Immunogen; SDS-PAGE; WB.
EPB212Hu61 Eukaryotic Chromogranin A (CHGA) Positive Control; Immunogen; SDS-PAGE; WB.
APB212Hu61 Active Chromogranin A (CHGA) Cell culture; Activity Assays.
Antibodies PAB212Hu01 Polyclonal Antibody to Chromogranin A (CHGA) WB; IHC; ICC; IP.
MAB212Hu22 Monoclonal Antibody to Chromogranin A (CHGA) WB; IHC; ICC; IP.
LAB212Hu71 Biotin-Linked Polyclonal Antibody to Chromogranin A (CHGA) WB; IHC; ICC.
Assay Kits SEB212Hu ELISA Kit for Chromogranin A (CHGA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB212Mu01 Recombinant Chromogranin A (CHGA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB212Mu01 Polyclonal Antibody to Chromogranin A (CHGA) WB; IHC; ICC; IP.
Assay Kits SEB212Mu ELISA Kit for Chromogranin A (CHGA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB212Ra01 Recombinant Chromogranin A (CHGA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB212Ra01 Polyclonal Antibody to Chromogranin A (CHGA) WB; IHC; ICC; IP.
MAB212Ra21 Monoclonal Antibody to Chromogranin A (CHGA) WB; IHC; ICC; IP.
Assay Kits SEB212Ra ELISA Kit for Chromogranin A (CHGA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB212Po01 Recombinant Chromogranin A (CHGA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB212Po01 Polyclonal Antibody to Chromogranin A (CHGA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Chromogranin A (CHGA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromogranin A (CHGA) ELISA Kit Customized Service Offer
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  19. "Enrichment of glycopeptides for glycan structure and attachment site identification."Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Catestatin: a multifunctional peptide from chromogranin A."Regul. Pept. 162:33-43(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines."Immunology 132:527-539(2011) [PubMed] [Europe PMC] [Abstract]
  22. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
  23. "Antioxidant properties of a human neuropeptide and its protective effect on free radical-induced DNA damage."J. Pept. Sci. 20:429-437(2014) [PubMed] [Europe PMC] [Abstract]
  24. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  25. "Conformational preferences and activities of peptides from the catecholamine release-inhibitory (catestatin) region of chromogranin A."Regul. Pept. 118:75-87(2004) [PubMed] [Europe PMC] [Abstract]
  26. "Both rare and common polymorphisms contribute functional variation at CHGA, a regulator of catecholamine physiology."Am. J. Hum. Genet. 74:197-207(2004) [PubMed] [Europe PMC] [Abstract]
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  28. "Catecholamine release-inhibitory peptide catestatin (chromogranin A(352-372)): naturally occurring amino acid variant Gly364Ser causes profound changes in human autonomic activity and alters risk for hypertension."Circulation 115:2271-2281(2007) [PubMed] [Europe PMC] [Abstract]
  29. "Proteolytic cleavage of human chromogranin a containing naturally occurring catestatin variants: differential processing at catestatin region by plasmin."Endocrinology 149:749-757(2008) [PubMed] [Europe PMC] [Abstract]