Aspartate Aminotransferase (AST)

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cCAT; AAT; ASAT; SGOT; GOT1; Cysteine transaminase, cytoplasmic; Transaminase A; Aspartate Transaminase 1,Cytoplasmic; Glutamic-Oxaloacetic Transaminase 1,Soluble

Aspartate Aminotransferase (AST)

AST) is similar to alanine transaminase (ALT) in that it is another enzyme associated with liver parenchymal cells.It is raised in acute liver damage. It is also present in red blood cells and cardiac muscle, skeletal muscle, and kidney and brain tissue, and may be elevated due to damage to those sources as well.AST was defined as a biochemical marker for the diagnosis of acute myocardial infarction in 1954. However the use of AST for such a diagnosis is now redundant and has been superseded by the cardiac troponins.

The 2 isoenzymes are homodimeric. In liver about 80% of the enzyme activity is mitochondrial in origin, whereas in serum the enzyme activity is largely cytosolic.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB214Hu01 Recombinant Aspartate Aminotransferase (AST) Positive Control; Immunogen; SDS-PAGE; WB.
EPB214Hu51 Eukaryotic Aspartate Aminotransferase (AST) Positive Control; Immunogen; SDS-PAGE; WB.
APB214Hu51 Active Aspartate Aminotransferase (AST) Cell culture; Activity Assays.
APB214Hu01 Active Aspartate Aminotransferase (AST) Cell culture; Activity Assays.
Antibodies PAB214Hu01 Polyclonal Antibody to Aspartate Aminotransferase (AST) WB; IHC; ICC; IP.
MAB214Hu22 Monoclonal Antibody to Aspartate Aminotransferase (AST) WB; IHC; ICC; IP.
LAB214Hu71 Biotin-Linked Polyclonal Antibody to Aspartate Aminotransferase (AST) WB; IHC; ICC.
LAB214Hu81 FITC-Linked Polyclonal Antibody to Aspartate Aminotransferase (AST) WB; IHC; ICC; IF.
PAB214Hu51 Polyclonal Antibody to Aspartate Aminotransferase (AST) WB; IHC; ICC; IP.
PAB214Hu07 Polyclonal Antibody to Aspartate Aminotransferase (AST) WB; IHC; ICC; IP.
MAB214Hu21 Monoclonal Antibody to Aspartate Aminotransferase (AST) WB; IHC
LAB214Hu72 Biotin-Linked Monoclonal Antibody to Aspartate Aminotransferase (AST) WB; IHC; ICC.
Assay Kits SEB214Hu ELISA Kit for Aspartate Aminotransferase (AST) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB214Mu01 Recombinant Aspartate Aminotransferase (AST) Positive Control; Immunogen; SDS-PAGE; WB.
RPB214Mu02 Recombinant Aspartate Aminotransferase (AST) Positive Control; Immunogen; SDS-PAGE; WB.
APB214Mu01 Active Aspartate Aminotransferase (AST) Cell culture; Activity Assays.
Antibodies PAB214Mu01 Polyclonal Antibody to Aspartate Aminotransferase (AST) WB; IHC; ICC; IP.
LAB214Mu71 Biotin-Linked Polyclonal Antibody to Aspartate Aminotransferase (AST) WB; IHC; ICC.
LAB214Mu81 FITC-Linked Polyclonal Antibody to Aspartate Aminotransferase (AST) WB; IHC; ICC; IF.
PAB214Mu02 Polyclonal Antibody to Aspartate Aminotransferase (AST) WB; IHC; ICC; IP.
MAB214Mu21 Monoclonal Antibody to Aspartate Aminotransferase (AST) WB; IHC; ICC; IP.
MAB214Mu22 Monoclonal Antibody to Aspartate Aminotransferase (AST) WB; IHC; ICC; IP.
Assay Kits SEB214Mu ELISA Kit for Aspartate Aminotransferase (AST) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB214Ra01 Recombinant Aspartate Aminotransferase (AST) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB214Ra01 Polyclonal Antibody to Aspartate Aminotransferase (AST) WB; IHC; ICC; IP.
LAB214Ra71 Biotin-Linked Polyclonal Antibody to Aspartate Aminotransferase (AST) WB; IHC; ICC.
MAB214Ra21 Monoclonal Antibody to Aspartate Aminotransferase (AST) WB; IHC; ICC; IP.
MAB214Ra22 Monoclonal Antibody to Aspartate Aminotransferase (AST) WB; IHC; ICC; IP.
Assay Kits SEB214Ra ELISA Kit for Aspartate Aminotransferase (AST) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aspartate Aminotransferase (AST) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aspartate Aminotransferase (AST) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aspartate Aminotransferase (AST) Polyclonal Antibody Customized Service Offer
Assay Kits SEB214Rb ELISA Kit for Aspartate Aminotransferase (AST) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aspartate Aminotransferase (AST) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aspartate Aminotransferase (AST) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aspartate Aminotransferase (AST) Polyclonal Antibody Customized Service Offer
Assay Kits SEB214Po ELISA Kit for Aspartate Aminotransferase (AST) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB214Bo01 Recombinant Aspartate Aminotransferase (AST) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB214Bo01 Polyclonal Antibody to Aspartate Aminotransferase (AST) WB; IHC; ICC; IP.
MAB214Bo21 Monoclonal Antibody to Aspartate Aminotransferase (AST) WB; IHC; ICC; IP.
Assay Kits SEB214Bo ELISA Kit for Aspartate Aminotransferase (AST) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aspartate Aminotransferase (AST) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aspartate Aminotransferase (AST) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aspartate Aminotransferase (AST) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aspartate Aminotransferase (AST) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aspartate Aminotransferase (AST) ELISA Kit Customized Service Offer
  1. "Properties of human liver cytosolic aspartate aminotransferase mRNAs generated by alternative polyadenylation site selection."Biochemistry 29:5293-5299(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The amino acid sequence of cytosolic aspartate aminotransferase from human liver."Biochem. J. 270:651-657(1990) [PubMed] [Europe PMC] [Abstract]
  6. "Amino acids and transaminases activity in ventricular CSF and in brain of normal and Alzheimer patients."Neurosci. Lett. 388:49-53(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Genome-wide association study identifies genetic variants in GOT1 determining serum aspartate aminotransferase levels."J. Hum. Genet. 56:801-805(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Relationship between glutamate, GOT and GPT levels in maternal and fetal blood: a potential mechanism for fetal neuroprotection."Early Hum. Dev. 88:773-778(2012) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of human glutamate oxaloacetate transaminase 1 (GOT1)."Submitted (AUG-2009) to the PDB data bank