Corticosteroid Binding Globulin (CBG)
[Edit]SERPINA6; Transcortin; Serpin A6; Serpin Peptidase Inhibitor,Clade A,Member 6(Alpha-1 Antiproteinase; Antitrypsin)
-91226.jpg)
Transcortin is produced by the liver and is regulated by estrogens. Therefore, plasma transcortin levels increase during pregnancy, and are decreased in cirrhosis.Transcortin is produced by the liver and is regulated by estrogens. Therefore, plasma transcortin levels increase during pregnancy, and are decreased in cirrhosis.
Corticosteroid-binding globulin is an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB226Mu01 | Recombinant Corticosteroid Binding Globulin (CBG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB226Mu02 | Recombinant Corticosteroid Binding Globulin (CBG) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| RPB226Mu03 | Recombinant Corticosteroid Binding Globulin (CBG) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB226Mu01 | Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) | WB; IHC; ICC; IP. |
| PAB226Mu03 | Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) | WB; IHC; ICC; IP. | |
| PAB226Mu02 | Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) | WB; IHC; ICC; IP. | |
| LAB226Mu71 | Biotin-Linked Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) | WB; IHC; ICC. | |
| Assay Kits | SEB226Mu | ELISA Kit for Corticosteroid Binding Globulin (CBG) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
- "Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors."Proc. Natl. Acad. Sci. U.S.A. 84:5153-5157(1987) [PubMed] [Europe PMC] [Abstract]
- "Corticosteroid binding globulin, testosterone-estradiol binding globulin, and androgen binding protein belong to protein families distinct from steroid receptors."J. Steroid Biochem. 30:131-139(1988) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Comparative structural analyses of corticosteroid binding globulin."J. Steroid Biochem. 29:213-220(1988) [PubMed] [Europe PMC] [Abstract]
- "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
- "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
- "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
- "The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release."J. Mol. Biol. 380:244-251(2008) [PubMed] [Europe PMC] [Abstract]
- "A Leu-->His substitution at residue 93 in human corticosteroid binding globulin results in reduced affinity for cortisol."J. Steroid Biochem. Mol. Biol. 42:671-676(1992) [PubMed] [Europe PMC] [Abstract]
- "Decreased cortisol-binding affinity of transcortin Leuven is associated with an amino acid substitution at residue-93."Steroids 58:275-277(1993) [PubMed] [Europe PMC] [Abstract]
- "Novel human corticosteroid-binding globulin variant with low cortisol-binding affinity."J. Clin. Endocrinol. Metab. 85:361-367(2000) [PubMed] [Europe PMC] [Abstract]
- "Haploinsufficiency of the SERPINA6 gene is associated with severe muscle fatigue: A de novo mutation in corticosteroid-binding globulin deficiency."J. Neural Transm. 114:563-569(2007) [PubMed] [Europe PMC] [Abstract]